Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein

Lysosomal acid lipase (LAL) plays an important role in lipid metabolism by performing hydrolysis of triglycerides and cholesteryl esters in the lysosome. Based upon characteristics of LAL purified from human liver, it has been proposed that LAL is a proprotein with a 55 residue propeptide that may b...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2020-03, Vol.88 (3), p.440-448
Hauptverfasser:	Strøm, Thea B., Vinje, Terje, Bjune, Katrine, Costa, Luís T., Laerdahl, Jon K., Leren, Trond P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bioinformatics cholesterol cholesteryl ester storage disease Cleavage Enzyme Assays Esters Fractionation Furin Gene Expression HeLa Cells Hep G2 Cells Humans Hymecromone - analogs & derivatives Hymecromone - chemistry Hymecromone - metabolism Kinetics Lipase Lipid metabolism Lipids lysosomal acid lipase Lysosomes - chemistry Lysosomes - enzymology Models, Molecular molecular biology Mutation Plasmids - chemistry Plasmids - metabolism proprotein Protein Structure, Secondary Proteinase Proteolysis Proteolytic enzymes Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Residues Sequence Alignment Sequence Homology, Amino Acid Sterol Esterase - chemistry Sterol Esterase - genetics Sterol Esterase - metabolism Substrate Specificity Triglycerides
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