The potential impact of COMT gene variants on dopamine regulation and phenotypic traits of ASD patients

Catechol-O-methyltransferase (COMT) enzyme has a major role in the adjustment of catechol-dependent functions, for example, cognition, cardiac function, and pain processing. The pathogenesis of autism may be related to dysfunction in the midbrain dopaminergic system. Therefore, we aimed to clarify h...

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Veröffentlicht in:	Behavioural brain research 2020-01, Vol.378, p.112272-112272, Article 112272
Hauptverfasser:	Esmaiel, Nora N., Ashaat, Engy A., Mosaad, Rehab, Fayez, Alaaeldin, Ibrahim, Mona, Abdallah, Zeinab Y., Issa, Mahmoud Y., Salem, Sohair, Ramadan, Abeer, El Wakeel, Maged A., Ashaat, Neveen A., Zaki, Maha S., Ismail, Samira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Autism spectrum disorder Autism Spectrum Disorder - blood Autism Spectrum Disorder - genetics Autism Spectrum Disorder - physiopathology Catechol O-Methyltransferase - genetics Child Child, Preschool COMT Dopamine - blood Electroencephalography Female Humans Male Phenotype Polymorphism, Single Nucleotide Sequence Analysis, DNA Severity of Illness Index SNPs
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