MpTCP1 controls cell proliferation and redox processes in Marchantia polymorpha
• TCP transcription factors are key regulators of angiosperm cell proliferation processes. It is unknown whether their regulatory growth capacities are conserved across land plants, which we examined in liverworts, one of the earliest diverging land plant lineages. • We generated knockout mutants fo...
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| Veröffentlicht in: | The New phytologist 2019-12, Vol.224 (4), p.1627-1641 |
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| container_title | The New phytologist |
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| creator | Busch, Andrea Deckena, Marek Almeida-Trapp, Marilia Kopischke, Sarah Kock, Cilian Schüssler, Esther Tsiantis, Miltos Mithöfer, Axel Zachgo, Sabine |
| description | • TCP transcription factors are key regulators of angiosperm cell proliferation processes. It is unknown whether their regulatory growth capacities are conserved across land plants, which we examined in liverworts, one of the earliest diverging land plant lineages.
• We generated knockout mutants for MpTCP1, the single TCP-P clade gene in Marchantia polymorpha, and characterized its function by conducting cell proliferation and morphological analyses as well as messenger RNA expression, transcriptome, chemical, and DNA binding studies.
• Mptcp1ge
lines show a reduced vegetative thallus growth and extra tissue formation in female reproductive structures. Additionally, mutant plants reveal increased hydrogen peroxide (H₂O₂) levels and an enhanced pigmentation in the thallus caused by formation of secondary metabolites, such as aminochromes. MpTCP1 proteins interact redox dependently with DNA and regulate the expression of a comprehensive redox network, comprising enzymes involved in H₂O₂ metabolism.
• MpTCP1 regulates Marchantia growth in a context-dependent manner. Redox sensitivity of the DNA binding capacity of MpTCP1 proteins provides a mechanism to respond to altered redox conditions. Our data suggest that MpTCP1 activity could thereby have contributed to diversification of land plant morphologies and to adaptations to abiotic and biotic challenges, as experienced by liverworts during early land plant colonization. |
| doi_str_mv | 10.1111/nph.16132 |
| format | Article |
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• We generated knockout mutants for MpTCP1, the single TCP-P clade gene in Marchantia polymorpha, and characterized its function by conducting cell proliferation and morphological analyses as well as messenger RNA expression, transcriptome, chemical, and DNA binding studies.
• Mptcp1ge
lines show a reduced vegetative thallus growth and extra tissue formation in female reproductive structures. Additionally, mutant plants reveal increased hydrogen peroxide (H₂O₂) levels and an enhanced pigmentation in the thallus caused by formation of secondary metabolites, such as aminochromes. MpTCP1 proteins interact redox dependently with DNA and regulate the expression of a comprehensive redox network, comprising enzymes involved in H₂O₂ metabolism.
• MpTCP1 regulates Marchantia growth in a context-dependent manner. Redox sensitivity of the DNA binding capacity of MpTCP1 proteins provides a mechanism to respond to altered redox conditions. Our data suggest that MpTCP1 activity could thereby have contributed to diversification of land plant morphologies and to adaptations to abiotic and biotic challenges, as experienced by liverworts during early land plant colonization.</description><identifier>ISSN: 0028-646X</identifier><identifier>EISSN: 1469-8137</identifier><identifier>DOI: 10.1111/nph.16132</identifier><identifier>PMID: 31433873</identifier><language>eng</language><publisher>England: Wiley</publisher><subject>Adaptation ; Binding ; Cell growth ; Cell proliferation ; Colonization ; Colour ; Deoxyribonucleic acid ; DNA ; DNA binding ; evolution ; Gene expression ; Hydrogen peroxide ; Marchantia polymorpha ; Marchantiophyta ; Metabolism ; Metabolites ; Morphology ; Mutants ; Nucleic acids ; Organic chemistry ; Oxidoreductions ; Pigmentation ; Proliferation ; Proteins ; redox regulation ; Regulators ; RNA ; Secondary metabolites ; TCP ; Thallus ; Transcription ; Transcription factors</subject><ispartof>The New phytologist, 2019-12, Vol.224 (4), p.1627-1641</ispartof><rights>2019 The Authors © 2019 New Phytologist Trust</rights><rights>2019 The Authors. New Phytologist © 2019 New Phytologist Trust</rights><rights>2019 The Authors. New Phytologist © 2019 New Phytologist Trust.</rights><rights>Copyright © 2019 New Phytologist Trust</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-5229-6913 ; 0000-0002-6666-1499 ; 0000-0002-9980-322X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26837880$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26837880$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,1417,1433,27924,27925,45574,45575,46409,46833,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31433873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Busch, Andrea</creatorcontrib><creatorcontrib>Deckena, Marek</creatorcontrib><creatorcontrib>Almeida-Trapp, Marilia</creatorcontrib><creatorcontrib>Kopischke, Sarah</creatorcontrib><creatorcontrib>Kock, Cilian</creatorcontrib><creatorcontrib>Schüssler, Esther</creatorcontrib><creatorcontrib>Tsiantis, Miltos</creatorcontrib><creatorcontrib>Mithöfer, Axel</creatorcontrib><creatorcontrib>Zachgo, Sabine</creatorcontrib><title>MpTCP1 controls cell proliferation and redox processes in Marchantia polymorpha</title><title>The New phytologist</title><addtitle>New Phytol</addtitle><description>• TCP transcription factors are key regulators of angiosperm cell proliferation processes. It is unknown whether their regulatory growth capacities are conserved across land plants, which we examined in liverworts, one of the earliest diverging land plant lineages.
• We generated knockout mutants for MpTCP1, the single TCP-P clade gene in Marchantia polymorpha, and characterized its function by conducting cell proliferation and morphological analyses as well as messenger RNA expression, transcriptome, chemical, and DNA binding studies.
• Mptcp1ge
lines show a reduced vegetative thallus growth and extra tissue formation in female reproductive structures. Additionally, mutant plants reveal increased hydrogen peroxide (H₂O₂) levels and an enhanced pigmentation in the thallus caused by formation of secondary metabolites, such as aminochromes. MpTCP1 proteins interact redox dependently with DNA and regulate the expression of a comprehensive redox network, comprising enzymes involved in H₂O₂ metabolism.
• MpTCP1 regulates Marchantia growth in a context-dependent manner. Redox sensitivity of the DNA binding capacity of MpTCP1 proteins provides a mechanism to respond to altered redox conditions. Our data suggest that MpTCP1 activity could thereby have contributed to diversification of land plant morphologies and to adaptations to abiotic and biotic challenges, as experienced by liverworts during early land plant colonization.</description><subject>Adaptation</subject><subject>Binding</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Colonization</subject><subject>Colour</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA binding</subject><subject>evolution</subject><subject>Gene expression</subject><subject>Hydrogen peroxide</subject><subject>Marchantia polymorpha</subject><subject>Marchantiophyta</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Morphology</subject><subject>Mutants</subject><subject>Nucleic acids</subject><subject>Organic chemistry</subject><subject>Oxidoreductions</subject><subject>Pigmentation</subject><subject>Proliferation</subject><subject>Proteins</subject><subject>redox regulation</subject><subject>Regulators</subject><subject>RNA</subject><subject>Secondary metabolites</subject><subject>TCP</subject><subject>Thallus</subject><subject>Transcription</subject><subject>Transcription factors</subject><issn>0028-646X</issn><issn>1469-8137</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNpdkTtPwzAUhS0EoqUw8ANAkVhY0vptZ0QVUKSWdigSW-TEjpoqjYOdCPrvcR90wIuv7v2OfXQPALcIDlE4o7pZDRFHBJ-BPqI8iSUi4hz0IcQy5pR_9sCV92sIYcI4vgQ9gighUpA-mM-a5XiBotzWrbOVj3JTVVETyrIwTrWlrSNV68gZbX92_dx4b3xU1tFMuXyl6rZUUWOr7ca6ZqWuwUWhKm9ujvcAfLw8L8eTeDp_fRs_TeM1hRjHtMg4h8ZAVmgBtRAG5zSjCU80zjlnCZRM5VoJWuicIY0YYVmBBGUCFoIxMgCPh3eDpa_O-DbdlH7nXdXGdj7FBCIpaUJ4QB_-oWvbuTq4CxTClEsSdjcA90eqyzZGp40rN8pt079VBWB0AL7LymxPcwTTXQZpyCDdZ5C-Lyb7IijuDoq1b607KXD4UEgJyS_Qk4FO</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Busch, Andrea</creator><creator>Deckena, Marek</creator><creator>Almeida-Trapp, Marilia</creator><creator>Kopischke, Sarah</creator><creator>Kock, Cilian</creator><creator>Schüssler, Esther</creator><creator>Tsiantis, Miltos</creator><creator>Mithöfer, Axel</creator><creator>Zachgo, Sabine</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>7QO</scope><scope>7SN</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5229-6913</orcidid><orcidid>https://orcid.org/0000-0002-6666-1499</orcidid><orcidid>https://orcid.org/0000-0002-9980-322X</orcidid></search><sort><creationdate>201912</creationdate><title>MpTCP1 controls cell proliferation and redox processes in Marchantia polymorpha</title><author>Busch, Andrea ; Deckena, Marek ; Almeida-Trapp, Marilia ; Kopischke, Sarah ; Kock, Cilian ; Schüssler, Esther ; Tsiantis, Miltos ; Mithöfer, Axel ; Zachgo, Sabine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j4022-4fb660ee05fd70d77e2c4b4969d2c6659085acda74fdc51d1535bf174570f7553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adaptation</topic><topic>Binding</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Colonization</topic><topic>Colour</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA binding</topic><topic>evolution</topic><topic>Gene expression</topic><topic>Hydrogen peroxide</topic><topic>Marchantia polymorpha</topic><topic>Marchantiophyta</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Morphology</topic><topic>Mutants</topic><topic>Nucleic acids</topic><topic>Organic chemistry</topic><topic>Oxidoreductions</topic><topic>Pigmentation</topic><topic>Proliferation</topic><topic>Proteins</topic><topic>redox regulation</topic><topic>Regulators</topic><topic>RNA</topic><topic>Secondary metabolites</topic><topic>TCP</topic><topic>Thallus</topic><topic>Transcription</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Busch, Andrea</creatorcontrib><creatorcontrib>Deckena, Marek</creatorcontrib><creatorcontrib>Almeida-Trapp, Marilia</creatorcontrib><creatorcontrib>Kopischke, Sarah</creatorcontrib><creatorcontrib>Kock, Cilian</creatorcontrib><creatorcontrib>Schüssler, Esther</creatorcontrib><creatorcontrib>Tsiantis, Miltos</creatorcontrib><creatorcontrib>Mithöfer, Axel</creatorcontrib><creatorcontrib>Zachgo, Sabine</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New phytologist</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Busch, Andrea</au><au>Deckena, Marek</au><au>Almeida-Trapp, Marilia</au><au>Kopischke, Sarah</au><au>Kock, Cilian</au><au>Schüssler, Esther</au><au>Tsiantis, Miltos</au><au>Mithöfer, Axel</au><au>Zachgo, Sabine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MpTCP1 controls cell proliferation and redox processes in Marchantia polymorpha</atitle><jtitle>The New phytologist</jtitle><addtitle>New Phytol</addtitle><date>2019-12</date><risdate>2019</risdate><volume>224</volume><issue>4</issue><spage>1627</spage><epage>1641</epage><pages>1627-1641</pages><issn>0028-646X</issn><eissn>1469-8137</eissn><abstract>• TCP transcription factors are key regulators of angiosperm cell proliferation processes. It is unknown whether their regulatory growth capacities are conserved across land plants, which we examined in liverworts, one of the earliest diverging land plant lineages.
• We generated knockout mutants for MpTCP1, the single TCP-P clade gene in Marchantia polymorpha, and characterized its function by conducting cell proliferation and morphological analyses as well as messenger RNA expression, transcriptome, chemical, and DNA binding studies.
• Mptcp1ge
lines show a reduced vegetative thallus growth and extra tissue formation in female reproductive structures. Additionally, mutant plants reveal increased hydrogen peroxide (H₂O₂) levels and an enhanced pigmentation in the thallus caused by formation of secondary metabolites, such as aminochromes. MpTCP1 proteins interact redox dependently with DNA and regulate the expression of a comprehensive redox network, comprising enzymes involved in H₂O₂ metabolism.
• MpTCP1 regulates Marchantia growth in a context-dependent manner. Redox sensitivity of the DNA binding capacity of MpTCP1 proteins provides a mechanism to respond to altered redox conditions. Our data suggest that MpTCP1 activity could thereby have contributed to diversification of land plant morphologies and to adaptations to abiotic and biotic challenges, as experienced by liverworts during early land plant colonization.</abstract><cop>England</cop><pub>Wiley</pub><pmid>31433873</pmid><doi>10.1111/nph.16132</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-5229-6913</orcidid><orcidid>https://orcid.org/0000-0002-6666-1499</orcidid><orcidid>https://orcid.org/0000-0002-9980-322X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation Binding Cell growth Cell proliferation Colonization Colour Deoxyribonucleic acid DNA DNA binding evolution Gene expression Hydrogen peroxide Marchantia polymorpha Marchantiophyta Metabolism Metabolites Morphology Mutants Nucleic acids Organic chemistry Oxidoreductions Pigmentation Proliferation Proteins redox regulation Regulators RNA Secondary metabolites TCP Thallus Transcription Transcription factors |
| title | MpTCP1 controls cell proliferation and redox processes in Marchantia polymorpha |
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