Thigh muscle MRI findings in myopathy associated with anti‐mitochondrial antibody
Introduction Myopathy associated with anti‐mitochondrial antibody (AMA) has recently been characterized as a distinct type of idiopathic inflammatory myopathy. The purpose of this study is to evaluate the pattern of involvement in thigh muscles in AMA myopathy using MRI. Methods Six patients with AM...
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| Veröffentlicht in: | Muscle & nerve 2020-01, Vol.61 (1), p.81-87 |
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| creator | Minamiyama, Sumio Ueda, Sakiho Nakashima, Ran Yamakado, Hodaka Sakato, Yusuke Yamashita, Hirofumi Sawamoto, Nobukatsu Fujimoto, Ryota Nishino, Ichizo Urushitani, Makoto Mimori, Tsuneyo Takahashi, Ryosuke |
| description | Introduction
Myopathy associated with anti‐mitochondrial antibody (AMA) has recently been characterized as a distinct type of idiopathic inflammatory myopathy. The purpose of this study is to evaluate the pattern of involvement in thigh muscles in AMA myopathy using MRI.
Methods
Six patients with AMA myopathy were identified and their muscle MRI findings evaluated.
Results
On thigh muscle MRI, all six patients showed high signal intensity with short‐tau inversion recovery that reflected disease activity mostly in the adductor magnus, called a “cuneiform sign.” Fatty degeneration was also prominent in the adductor magnus, as well as the semimembranosus muscles.
Discussion
These characteristic changes on MRI contrast with those of other inflammatory myopathies. From these observations, we concluded that the localization pattern of the inflammatory changes in muscle MRI can contribute to the diagnosis of AMA myopathy. |
| doi_str_mv | 10.1002/mus.26731 |
| format | Article |
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Myopathy associated with anti‐mitochondrial antibody (AMA) has recently been characterized as a distinct type of idiopathic inflammatory myopathy. The purpose of this study is to evaluate the pattern of involvement in thigh muscles in AMA myopathy using MRI.
Methods
Six patients with AMA myopathy were identified and their muscle MRI findings evaluated.
Results
On thigh muscle MRI, all six patients showed high signal intensity with short‐tau inversion recovery that reflected disease activity mostly in the adductor magnus, called a “cuneiform sign.” Fatty degeneration was also prominent in the adductor magnus, as well as the semimembranosus muscles.
Discussion
These characteristic changes on MRI contrast with those of other inflammatory myopathies. From these observations, we concluded that the localization pattern of the inflammatory changes in muscle MRI can contribute to the diagnosis of AMA myopathy.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26731</identifier><identifier>PMID: 31588577</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adipose Tissue - pathology ; Adult ; Aged ; Antibodies ; anti‐mitochondrial antibody ; Atrophy ; Autoantibodies - immunology ; Autoimmune Diseases - complications ; Autoimmune Diseases - diagnostic imaging ; Degeneration ; Female ; Granuloma - pathology ; granulomatous ; Humans ; Hypertrophy ; Identification methods ; idiopathic inflammatory myopathies ; Inflammation ; Inflammatory diseases ; Localization ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mitochondria ; Mitochondria, Muscle - immunology ; Mitochondrial Myopathies - diagnostic imaging ; Mitochondrial Myopathies - etiology ; muscle MRI ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - pathology ; Muscles ; Musculoskeletal diseases ; Myopathy ; myositis ; Thigh ; Thigh - diagnostic imaging ; Thigh - pathology</subject><ispartof>Muscle & nerve, 2020-01, Vol.61 (1), p.81-87</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-253cb0fdfa9faf25e6b3503b982dd59c67ab43a126c848e2fe2fd863bc8ce2703</citedby><cites>FETCH-LOGICAL-c3531-253cb0fdfa9faf25e6b3503b982dd59c67ab43a126c848e2fe2fd863bc8ce2703</cites><orcidid>0000-0001-8147-7078 ; 0000-0001-9452-112X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26731$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26731$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31588577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minamiyama, Sumio</creatorcontrib><creatorcontrib>Ueda, Sakiho</creatorcontrib><creatorcontrib>Nakashima, Ran</creatorcontrib><creatorcontrib>Yamakado, Hodaka</creatorcontrib><creatorcontrib>Sakato, Yusuke</creatorcontrib><creatorcontrib>Yamashita, Hirofumi</creatorcontrib><creatorcontrib>Sawamoto, Nobukatsu</creatorcontrib><creatorcontrib>Fujimoto, Ryota</creatorcontrib><creatorcontrib>Nishino, Ichizo</creatorcontrib><creatorcontrib>Urushitani, Makoto</creatorcontrib><creatorcontrib>Mimori, Tsuneyo</creatorcontrib><creatorcontrib>Takahashi, Ryosuke</creatorcontrib><title>Thigh muscle MRI findings in myopathy associated with anti‐mitochondrial antibody</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction
Myopathy associated with anti‐mitochondrial antibody (AMA) has recently been characterized as a distinct type of idiopathic inflammatory myopathy. The purpose of this study is to evaluate the pattern of involvement in thigh muscles in AMA myopathy using MRI.
Methods
Six patients with AMA myopathy were identified and their muscle MRI findings evaluated.
Results
On thigh muscle MRI, all six patients showed high signal intensity with short‐tau inversion recovery that reflected disease activity mostly in the adductor magnus, called a “cuneiform sign.” Fatty degeneration was also prominent in the adductor magnus, as well as the semimembranosus muscles.
Discussion
These characteristic changes on MRI contrast with those of other inflammatory myopathies. From these observations, we concluded that the localization pattern of the inflammatory changes in muscle MRI can contribute to the diagnosis of AMA myopathy.</description><subject>Adipose Tissue - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Antibodies</subject><subject>anti‐mitochondrial antibody</subject><subject>Atrophy</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmune Diseases - complications</subject><subject>Autoimmune Diseases - diagnostic imaging</subject><subject>Degeneration</subject><subject>Female</subject><subject>Granuloma - pathology</subject><subject>granulomatous</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Identification methods</subject><subject>idiopathic inflammatory myopathies</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Localization</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitochondria</subject><subject>Mitochondria, Muscle - immunology</subject><subject>Mitochondrial Myopathies - diagnostic imaging</subject><subject>Mitochondrial Myopathies - etiology</subject><subject>muscle MRI</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscles</subject><subject>Musculoskeletal diseases</subject><subject>Myopathy</subject><subject>myositis</subject><subject>Thigh</subject><subject>Thigh - diagnostic imaging</subject><subject>Thigh - pathology</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAYwPEgipvTg19ACl700C0vTZseZfgy2BDcBt5KmqRrRtvMpmX05kfwM_pJbO30IAiBB8KPP8kDwCWCYwQhnuS1HWM_IOgIDBEMA9ejITsGQ4g85vokfB2AM2u3EELE_OAUDAiijNEgGILlKtWb1GkLIlPO4mXmJLqQuthYRxdO3pgdr9LG4dYaoXmlpLPXVerwotKf7x-5roxITSFLzbPvy9jI5hycJDyz6uIwR2D9cL-aPrnz58fZ9G7uCkIJcjElIoaJTHiY8ART5ceEQhKHDEtJQ-EHPPYIR9gXzGMKJ-2RzCexYELhAJIRuOm7u9K81cpWUa6tUFnGC2VqG2HS_pdB4nX0-g_dmros2te1CtMAkZCyVt32SpTG2lIl0a7UOS-bCMGo23SUd9lu0629OhTrOFfyV_6stgWTHux1ppr_S9FiveyTX1K4iVY</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Minamiyama, Sumio</creator><creator>Ueda, Sakiho</creator><creator>Nakashima, Ran</creator><creator>Yamakado, Hodaka</creator><creator>Sakato, Yusuke</creator><creator>Yamashita, Hirofumi</creator><creator>Sawamoto, Nobukatsu</creator><creator>Fujimoto, Ryota</creator><creator>Nishino, Ichizo</creator><creator>Urushitani, Makoto</creator><creator>Mimori, Tsuneyo</creator><creator>Takahashi, Ryosuke</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8147-7078</orcidid><orcidid>https://orcid.org/0000-0001-9452-112X</orcidid></search><sort><creationdate>202001</creationdate><title>Thigh muscle MRI findings in myopathy associated with anti‐mitochondrial antibody</title><author>Minamiyama, Sumio ; Ueda, Sakiho ; Nakashima, Ran ; Yamakado, Hodaka ; Sakato, Yusuke ; Yamashita, Hirofumi ; Sawamoto, Nobukatsu ; Fujimoto, Ryota ; Nishino, Ichizo ; Urushitani, Makoto ; Mimori, Tsuneyo ; Takahashi, Ryosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-253cb0fdfa9faf25e6b3503b982dd59c67ab43a126c848e2fe2fd863bc8ce2703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose Tissue - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Antibodies</topic><topic>anti‐mitochondrial antibody</topic><topic>Atrophy</topic><topic>Autoantibodies - immunology</topic><topic>Autoimmune Diseases - complications</topic><topic>Autoimmune Diseases - diagnostic imaging</topic><topic>Degeneration</topic><topic>Female</topic><topic>Granuloma - pathology</topic><topic>granulomatous</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Identification methods</topic><topic>idiopathic inflammatory myopathies</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Localization</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitochondria</topic><topic>Mitochondria, Muscle - immunology</topic><topic>Mitochondrial Myopathies - diagnostic imaging</topic><topic>Mitochondrial Myopathies - etiology</topic><topic>muscle MRI</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscles</topic><topic>Musculoskeletal diseases</topic><topic>Myopathy</topic><topic>myositis</topic><topic>Thigh</topic><topic>Thigh - diagnostic imaging</topic><topic>Thigh - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minamiyama, Sumio</creatorcontrib><creatorcontrib>Ueda, Sakiho</creatorcontrib><creatorcontrib>Nakashima, Ran</creatorcontrib><creatorcontrib>Yamakado, Hodaka</creatorcontrib><creatorcontrib>Sakato, Yusuke</creatorcontrib><creatorcontrib>Yamashita, Hirofumi</creatorcontrib><creatorcontrib>Sawamoto, Nobukatsu</creatorcontrib><creatorcontrib>Fujimoto, Ryota</creatorcontrib><creatorcontrib>Nishino, Ichizo</creatorcontrib><creatorcontrib>Urushitani, Makoto</creatorcontrib><creatorcontrib>Mimori, Tsuneyo</creatorcontrib><creatorcontrib>Takahashi, Ryosuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minamiyama, Sumio</au><au>Ueda, Sakiho</au><au>Nakashima, Ran</au><au>Yamakado, Hodaka</au><au>Sakato, Yusuke</au><au>Yamashita, Hirofumi</au><au>Sawamoto, Nobukatsu</au><au>Fujimoto, Ryota</au><au>Nishino, Ichizo</au><au>Urushitani, Makoto</au><au>Mimori, Tsuneyo</au><au>Takahashi, Ryosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thigh muscle MRI findings in myopathy associated with anti‐mitochondrial antibody</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2020-01</date><risdate>2020</risdate><volume>61</volume><issue>1</issue><spage>81</spage><epage>87</epage><pages>81-87</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Introduction
Myopathy associated with anti‐mitochondrial antibody (AMA) has recently been characterized as a distinct type of idiopathic inflammatory myopathy. The purpose of this study is to evaluate the pattern of involvement in thigh muscles in AMA myopathy using MRI.
Methods
Six patients with AMA myopathy were identified and their muscle MRI findings evaluated.
Results
On thigh muscle MRI, all six patients showed high signal intensity with short‐tau inversion recovery that reflected disease activity mostly in the adductor magnus, called a “cuneiform sign.” Fatty degeneration was also prominent in the adductor magnus, as well as the semimembranosus muscles.
Discussion
These characteristic changes on MRI contrast with those of other inflammatory myopathies. From these observations, we concluded that the localization pattern of the inflammatory changes in muscle MRI can contribute to the diagnosis of AMA myopathy.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31588577</pmid><doi>10.1002/mus.26731</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8147-7078</orcidid><orcidid>https://orcid.org/0000-0001-9452-112X</orcidid></addata></record> |
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| subjects | Adipose Tissue - pathology Adult Aged Antibodies anti‐mitochondrial antibody Atrophy Autoantibodies - immunology Autoimmune Diseases - complications Autoimmune Diseases - diagnostic imaging Degeneration Female Granuloma - pathology granulomatous Humans Hypertrophy Identification methods idiopathic inflammatory myopathies Inflammation Inflammatory diseases Localization Magnetic Resonance Imaging Male Middle Aged Mitochondria Mitochondria, Muscle - immunology Mitochondrial Myopathies - diagnostic imaging Mitochondrial Myopathies - etiology muscle MRI Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - pathology Muscles Musculoskeletal diseases Myopathy myositis Thigh Thigh - diagnostic imaging Thigh - pathology |
| title | Thigh muscle MRI findings in myopathy associated with anti‐mitochondrial antibody |
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