A Facile Assay of Epithelial-mesenchymal Transition Based on Cooperativity Quantification of Cellular Autonomous Motions

Epithelial-mesenchymal transition (EMT), a qualitative change in cell migration behavior during cancer invasion and metastasis, is becoming a new target for anticancer drugs. Therefore, it is crucial to develop in vitro assays for the evaluation of the abilities of drug candidates to control EMT pro...

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Veröffentlicht in:	Analytical Sciences 2020/02/10, Vol.36(2), pp.263-268
Hauptverfasser:	YAMAMOTO, Shota, MIYAMA, Tatsuya, KOMODA, Takafumi, SUGAWARA, Michiko, NONOMURA, Makiko, NAKANISHI, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Animals Antineoplastic drugs Antitumor agents cancer Cell adhesion & migration Cell Line, Tumor Cell migration Chemistry Curve fitting Dogs Drug development drug screening Epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology Growth factors Humans Madin Darby Canine Kidney Cells mathematical analysis Mesenchyme Metastases Organic chemistry Particle image velocimetry Time dependence Transforming Growth Factor beta1 - physiology Transforming growth factor-b1
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