Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice

Idiopathic pulmonary fibrosis (IPF) is a fatal growing problem, with limited therapeutic options. Transforming growth factor beta 1 (TGF-β1) plays a critical role in many pathological processes that characterize pulmonary fibrosis. Effective and well-tolerated antifibrotic agents that interfere with...

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Veröffentlicht in:	European journal of pharmacology 2019-12, Vol.864, p.172712-172712, Article 172712
Hauptverfasser:	Guo, Jiasen, Fang, Yinshan, Jiang, Fangxin, Li, Lian, Zhou, Honggang, Xu, Xiaojun, Ning, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Bleomycin - adverse effects Fibroblast Hesperidin - analogs & derivatives Hesperidin - pharmacology Hesperidin - therapeutic use Humans Lung - drug effects Lung - pathology Mice Myofibroblasts - drug effects Myofibroblasts - pathology Neohesperidin NIH 3T3 Cells Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - pathology Signal Transduction - drug effects Smad3 Protein - metabolism TGF-β1 Transforming Growth Factor beta1 - metabolism
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