Protein kinase CK2 is involved in zinc homeostasis in breast and prostate cancer cells

The intracellular zinc profiles of breast and prostate cancer cells are diametrically opposed, with hyper-accumulation of zinc in breast cancer, and low level in prostate cancer. This phenomenon is poorly understood. This study employs two breast and two prostate cancer cell lines to investigate the...

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Veröffentlicht in:	Biometals 2019-12, Vol.32 (6), p.861-873
Hauptverfasser:	Zaman, Mohammad S., Johnson, Adam J., Petersingham, Gayani, Muench, Gerald W., Dong, Qihan, Wu, Ming J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biochemistry Biomedical and Life Sciences Biotechnology Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Casein kinase II Casein Kinase II - antagonists & inhibitors Casein Kinase II - metabolism Cell Biology Cell Survival - drug effects Cell viability Confocal microscopy Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female Homeostasis Homeostasis - drug effects Humans Intracellular Kinases Life Sciences Low level Male MCF-7 Cells Medicine/Public Health Microbiology Pharmacology/Toxicology Plant Physiology Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein kinase C Proteins siRNA Structure-Activity Relationship Tumor cell lines Tumor Cells, Cultured Zinc Zinc Sulfate - metabolism Zinc Sulfate - pharmacology
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