Dual inhibition of BRAF and MEK increases expression of sodium iodide symporter in patient-derived papillary thyroid cancer cells in vitro

The majority of papillary thyroid cancers are driven by acquired mutations typically in the BRAF or RAS genes that aberrantly activate the mitogen-activated protein kinase pathway. This process leads to malignant transformation, dedifferentiation, and a decrease in the expression of the sodium-iodid...

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Veröffentlicht in:	Surgery 2020-01, Vol.167 (1), p.56-63
Hauptverfasser:	Ullmann, Timothy M., Liang, Heng, Moore, Maureen D., Al-Jamed, Isra, Gray, Katherine D., Limberg, Jessica, Stefanova, Dessislava, Buicko, Jessica L., Finnerty, Brendan, Beninato, Toni, Zarnegar, Rasa, Min, Irene M., Fahey, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemoradiotherapy - methods Female Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Humans Imidazoles - pharmacology Imidazoles - therapeutic use Iodine Radioisotopes - administration & dosage Iodine Radioisotopes - metabolism Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics Middle Aged Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mutation Oximes - pharmacology Oximes - therapeutic use Primary Cell Culture Prospective Studies Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Pyridones Pyrimidinones Radiation Tolerance - drug effects Radiation Tolerance - genetics Symporters - metabolism Thyroid Cancer, Papillary - genetics Thyroid Cancer, Papillary - pathology Thyroid Cancer, Papillary - therapy Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid Neoplasms - therapy Tumor Cells, Cultured Up-Regulation - drug effects
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