Association between IL-1B gene polymorphisms and Helicobacter pylori infection: A meta-analysis
To clarify the impact of IL-1B gene polymorphisms (IL-1B–511C/T, IL-1B–31C/T, IL-1B+3954C/T) in Helicobacter pylori (H. pylori) infection by mean of a meta-analysis. The relevant studies were retrieved from PubMed, Web of Science, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (...
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| Veröffentlicht in: | Microbial pathogenesis 2019-12, Vol.137, p.103769-103769, Article 103769 |
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| creator | Ren, Hong-Yue Wen, Lu-Sheng Geng, Yue-Hua Huang, Jiang-Bin Liu, Jin-Fa Shen, Dong-Yan Meng, Jia-Rong |
| description | To clarify the impact of IL-1B gene polymorphisms (IL-1B–511C/T, IL-1B–31C/T, IL-1B+3954C/T) in Helicobacter pylori (H. pylori) infection by mean of a meta-analysis.
The relevant studies were retrieved from PubMed, Web of Science, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases until September 9, 2018. Odds ratio (OR) and its 95% confidence intervals (CIs) were used to assess the associations. Statistical analyses of this meta-analysis were conducted by using STATA 12 software.
Totally, 45 articles including 9606 cases and 5654 controls were enrolled in this meta-analysis. Our results indicated that IL-1B–511C/T polymorphism was significantly related to an increased the risk of H. pylori infection under recessive model (OR = 1.13, 95% CI: 1.00–1.27, P = 0.048). However, no significant associations were obtained between H. pylori infection and IL-1B–31C/T as well as IL-1B+3954C/T polymorphisms under all models. In addition, subgroup analyses were also performed by country, study design, and detection methods of H. pylori.
This meta-analysis suggested that IL-1B–511C/T polymorphism was related to the risk of H. pylori infection. Further larger studies with high quality are needed to conform these findings.
•45 articles including 9606 cases and 5654 controls were enrolled.•IL-1B–511C/T polymorphism was related to H. pylori infection under recessive model.•IL-1B–31C/T polymorphisms were not associated to H. pylori infection.•IL-1B+3954C/T polymorphisms were not associated to H. pylori infection. |
| doi_str_mv | 10.1016/j.micpath.2019.103769 |
| format | Article |
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The relevant studies were retrieved from PubMed, Web of Science, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases until September 9, 2018. Odds ratio (OR) and its 95% confidence intervals (CIs) were used to assess the associations. Statistical analyses of this meta-analysis were conducted by using STATA 12 software.
Totally, 45 articles including 9606 cases and 5654 controls were enrolled in this meta-analysis. Our results indicated that IL-1B–511C/T polymorphism was significantly related to an increased the risk of H. pylori infection under recessive model (OR = 1.13, 95% CI: 1.00–1.27, P = 0.048). However, no significant associations were obtained between H. pylori infection and IL-1B–31C/T as well as IL-1B+3954C/T polymorphisms under all models. In addition, subgroup analyses were also performed by country, study design, and detection methods of H. pylori.
This meta-analysis suggested that IL-1B–511C/T polymorphism was related to the risk of H. pylori infection. Further larger studies with high quality are needed to conform these findings.
•45 articles including 9606 cases and 5654 controls were enrolled.•IL-1B–511C/T polymorphism was related to H. pylori infection under recessive model.•IL-1B–31C/T polymorphisms were not associated to H. pylori infection.•IL-1B+3954C/T polymorphisms were not associated to H. pylori infection.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2019.103769</identifier><identifier>PMID: 31580959</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Genetic Predisposition to Disease ; Helicobacter Infections - genetics ; Helicobacter Infections - metabolism ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - genetics ; Helicobacter pylori - physiology ; Humans ; IL-1B ; Infection ; Interleukin-1beta - genetics ; Interleukin-1beta - metabolism ; Polymorphism, Single Nucleotide ; Polymorphisms</subject><ispartof>Microbial pathogenesis, 2019-12, Vol.137, p.103769-103769, Article 103769</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-67131edeca89960797efe32f168c5c20506e5c4334a74ce7c855839e61fd16ec3</citedby><cites>FETCH-LOGICAL-c431t-67131edeca89960797efe32f168c5c20506e5c4334a74ce7c855839e61fd16ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2019.103769$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31580959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Hong-Yue</creatorcontrib><creatorcontrib>Wen, Lu-Sheng</creatorcontrib><creatorcontrib>Geng, Yue-Hua</creatorcontrib><creatorcontrib>Huang, Jiang-Bin</creatorcontrib><creatorcontrib>Liu, Jin-Fa</creatorcontrib><creatorcontrib>Shen, Dong-Yan</creatorcontrib><creatorcontrib>Meng, Jia-Rong</creatorcontrib><title>Association between IL-1B gene polymorphisms and Helicobacter pylori infection: A meta-analysis</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>To clarify the impact of IL-1B gene polymorphisms (IL-1B–511C/T, IL-1B–31C/T, IL-1B+3954C/T) in Helicobacter pylori (H. pylori) infection by mean of a meta-analysis.
The relevant studies were retrieved from PubMed, Web of Science, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases until September 9, 2018. Odds ratio (OR) and its 95% confidence intervals (CIs) were used to assess the associations. Statistical analyses of this meta-analysis were conducted by using STATA 12 software.
Totally, 45 articles including 9606 cases and 5654 controls were enrolled in this meta-analysis. Our results indicated that IL-1B–511C/T polymorphism was significantly related to an increased the risk of H. pylori infection under recessive model (OR = 1.13, 95% CI: 1.00–1.27, P = 0.048). However, no significant associations were obtained between H. pylori infection and IL-1B–31C/T as well as IL-1B+3954C/T polymorphisms under all models. In addition, subgroup analyses were also performed by country, study design, and detection methods of H. pylori.
This meta-analysis suggested that IL-1B–511C/T polymorphism was related to the risk of H. pylori infection. Further larger studies with high quality are needed to conform these findings.
•45 articles including 9606 cases and 5654 controls were enrolled.•IL-1B–511C/T polymorphism was related to H. pylori infection under recessive model.•IL-1B–31C/T polymorphisms were not associated to H. pylori infection.•IL-1B+3954C/T polymorphisms were not associated to H. pylori infection.</description><subject>Genetic Predisposition to Disease</subject><subject>Helicobacter Infections - genetics</subject><subject>Helicobacter Infections - metabolism</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - genetics</subject><subject>Helicobacter pylori - physiology</subject><subject>Humans</subject><subject>IL-1B</subject><subject>Infection</subject><subject>Interleukin-1beta - genetics</subject><subject>Interleukin-1beta - metabolism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Polymorphisms</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BJCXbFJm4sSJ2aCCeEmV2MDacp0JuEriYKeg_j2pWtiyGml07h3NYewcYYqA8mo5bZ3tzfAxTQHVuBOFVHtsgqBkgimU-2wCZZkmGSAcseMYlwCgMqEO2ZHAvASVqwnTsxi9dWZwvuMLGr6JOv48T_CWv1NHvPfNuvWh_3Cxjdx0FX-ixlm_MHagwPt144PjrqvJbiqu-Yy3NJjEdKZZRxdP2UFtmkhnu3nC3h7uX--ekvnL4_PdbJ7YTOCQyAIFUkXWlEpJKFRBNYm0Rlna3KaQg6R8REVmisxSYcs8L4UiiXWFkqw4YZfb3j74zxXFQbcuWmoa05FfRZ0KwDEus2xE8y1qg48xUK374FoT1hpBb9zqpd651Ru3eut2zF3sTqwWLVV_qV-ZI3CzBWh89MtR0NE66ixVLox6dOXdPyd-ANCmjTY</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Ren, Hong-Yue</creator><creator>Wen, Lu-Sheng</creator><creator>Geng, Yue-Hua</creator><creator>Huang, Jiang-Bin</creator><creator>Liu, Jin-Fa</creator><creator>Shen, Dong-Yan</creator><creator>Meng, Jia-Rong</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201912</creationdate><title>Association between IL-1B gene polymorphisms and Helicobacter pylori infection: A meta-analysis</title><author>Ren, Hong-Yue ; Wen, Lu-Sheng ; Geng, Yue-Hua ; Huang, Jiang-Bin ; Liu, Jin-Fa ; Shen, Dong-Yan ; Meng, Jia-Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-67131edeca89960797efe32f168c5c20506e5c4334a74ce7c855839e61fd16ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Genetic Predisposition to Disease</topic><topic>Helicobacter Infections - genetics</topic><topic>Helicobacter Infections - metabolism</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - genetics</topic><topic>Helicobacter pylori - physiology</topic><topic>Humans</topic><topic>IL-1B</topic><topic>Infection</topic><topic>Interleukin-1beta - genetics</topic><topic>Interleukin-1beta - metabolism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Polymorphisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Hong-Yue</creatorcontrib><creatorcontrib>Wen, Lu-Sheng</creatorcontrib><creatorcontrib>Geng, Yue-Hua</creatorcontrib><creatorcontrib>Huang, Jiang-Bin</creatorcontrib><creatorcontrib>Liu, Jin-Fa</creatorcontrib><creatorcontrib>Shen, Dong-Yan</creatorcontrib><creatorcontrib>Meng, Jia-Rong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Hong-Yue</au><au>Wen, Lu-Sheng</au><au>Geng, Yue-Hua</au><au>Huang, Jiang-Bin</au><au>Liu, Jin-Fa</au><au>Shen, Dong-Yan</au><au>Meng, Jia-Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between IL-1B gene polymorphisms and Helicobacter pylori infection: A meta-analysis</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>2019-12</date><risdate>2019</risdate><volume>137</volume><spage>103769</spage><epage>103769</epage><pages>103769-103769</pages><artnum>103769</artnum><issn>0882-4010</issn><eissn>1096-1208</eissn><abstract>To clarify the impact of IL-1B gene polymorphisms (IL-1B–511C/T, IL-1B–31C/T, IL-1B+3954C/T) in Helicobacter pylori (H. pylori) infection by mean of a meta-analysis.
The relevant studies were retrieved from PubMed, Web of Science, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases until September 9, 2018. Odds ratio (OR) and its 95% confidence intervals (CIs) were used to assess the associations. Statistical analyses of this meta-analysis were conducted by using STATA 12 software.
Totally, 45 articles including 9606 cases and 5654 controls were enrolled in this meta-analysis. Our results indicated that IL-1B–511C/T polymorphism was significantly related to an increased the risk of H. pylori infection under recessive model (OR = 1.13, 95% CI: 1.00–1.27, P = 0.048). However, no significant associations were obtained between H. pylori infection and IL-1B–31C/T as well as IL-1B+3954C/T polymorphisms under all models. In addition, subgroup analyses were also performed by country, study design, and detection methods of H. pylori.
This meta-analysis suggested that IL-1B–511C/T polymorphism was related to the risk of H. pylori infection. Further larger studies with high quality are needed to conform these findings.
•45 articles including 9606 cases and 5654 controls were enrolled.•IL-1B–511C/T polymorphism was related to H. pylori infection under recessive model.•IL-1B–31C/T polymorphisms were not associated to H. pylori infection.•IL-1B+3954C/T polymorphisms were not associated to H. pylori infection.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31580959</pmid><doi>10.1016/j.micpath.2019.103769</doi><tpages>1</tpages></addata></record> |
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| subjects | Genetic Predisposition to Disease Helicobacter Infections - genetics Helicobacter Infections - metabolism Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - genetics Helicobacter pylori - physiology Humans IL-1B Infection Interleukin-1beta - genetics Interleukin-1beta - metabolism Polymorphism, Single Nucleotide Polymorphisms |
| title | Association between IL-1B gene polymorphisms and Helicobacter pylori infection: A meta-analysis |
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