Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine
Hymenaea cangaceira Pinto, Mansano & Azevedo (Fabaceae) is a Brazilian medicinal plant widely known as “Jatobá”. In folk medicine, it is used to treat infections, respiratory problems, rheumatism, antitumoral, inflammation and pain, however, no activity has been scientifically validated. This st...
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| Veröffentlicht in: | Journal of ethnopharmacology 2020-01, Vol.247, p.112265-112265, Article 112265 |
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| creator | Oliveira de Veras, Bruno Melo de Oliveira, Maria Betânia Granja da Silva Oliveira, Fernanda Queiroz dos Santos, Yago Saturnino de Oliveira, João Ricardhis Lúcia de Menezes Lima, Vera Guedes da Silva Almeida, Jackson Roberto Maria do Amaral Ferraz Navarro, Daniela Ribeiro de Oliveira Farias de Aguiar, Júlio César Aguiar, Jaciana dos Santos Gorlach-Lira, Krystyna Dias de Assis, Caio Rodrigo Vanusa da Silva, Márcia Catarina de Souza Lopes, Ana |
| description | Hymenaea cangaceira Pinto, Mansano & Azevedo (Fabaceae) is a Brazilian medicinal plant widely known as “Jatobá”. In folk medicine, it is used to treat infections, respiratory problems, rheumatism, antitumoral, inflammation and pain, however, no activity has been scientifically validated.
This study investigated chemical composition of essential oil from Hymenaea cangaceira (EOHc), antimicrobial, antinociceptive and antioxidant activities besides protection against DNA damage and hemolysis.
The essential oil was obtained by hydrodistillation, and characterized by GC-MS and GC-FID. The evaluation of antimicrobial activity was performed by microdilution method. The evaluation of the antioxidant activity was performed using the radicals DPPH, ABTS, O2- and OH-, and the protection of DNA damage using plasmid pBR322. Different experimental models were used to evaluate the antinociceptive effect (acetic acid and formalin), and evaluate the mechanisms of action involved with pharmacological antagonists (naloxone, atropine and gibenclamide) in mice. The essential oil was evaluated for hemolysis on human erythrocytes.
The extraction of EOHc showed a yield of 0.18% on a dry basis, presenting high content of hydrocarbon sesquiterpenes (79.04%), high antioxidant activity and protect DNA from damage, besides presenting antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria in vitro. It was found that the essential oil had no acute toxicity in mice up to 5000 mg/kg oral administration (o.a.), in addition to no hemolysis on human erythrocytes. The reduction of antinociceptive activity was 75%, with the opioid system as the mechanism of action.
Our results validate the main activities by the traditional use attributed to H. cangaceira for antimicrobial and analgesic activity. In addition, the oil has a potent antioxidant activity, protecting the body against oxidative stress damage, adding new value to an endemic species not known to the industry.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2019.112265 |
| format | Article |
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This study investigated chemical composition of essential oil from Hymenaea cangaceira (EOHc), antimicrobial, antinociceptive and antioxidant activities besides protection against DNA damage and hemolysis.
The essential oil was obtained by hydrodistillation, and characterized by GC-MS and GC-FID. The evaluation of antimicrobial activity was performed by microdilution method. The evaluation of the antioxidant activity was performed using the radicals DPPH, ABTS, O2- and OH-, and the protection of DNA damage using plasmid pBR322. Different experimental models were used to evaluate the antinociceptive effect (acetic acid and formalin), and evaluate the mechanisms of action involved with pharmacological antagonists (naloxone, atropine and gibenclamide) in mice. The essential oil was evaluated for hemolysis on human erythrocytes.
The extraction of EOHc showed a yield of 0.18% on a dry basis, presenting high content of hydrocarbon sesquiterpenes (79.04%), high antioxidant activity and protect DNA from damage, besides presenting antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria in vitro. It was found that the essential oil had no acute toxicity in mice up to 5000 mg/kg oral administration (o.a.), in addition to no hemolysis on human erythrocytes. The reduction of antinociceptive activity was 75%, with the opioid system as the mechanism of action.
Our results validate the main activities by the traditional use attributed to H. cangaceira for antimicrobial and analgesic activity. In addition, the oil has a potent antioxidant activity, protecting the body against oxidative stress damage, adding new value to an endemic species not known to the industry.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2019.112265</identifier><identifier>PMID: 31580941</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Acetic Acid - toxicity ; Analgesics - chemistry ; Analgesics - isolation & purification ; Analgesics - pharmacology ; Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antimicrobial activity ; Antinociceptive ; Antioxidant activity ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Brazil ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Essential oil ; Ethanol - chemistry ; Ethnopharmacology ; Fabaceae ; Formaldehyde - toxicity ; Humans ; Hymenaea - chemistry ; Medicine, Traditional - methods ; Mice ; Microbial Sensitivity Tests ; Nociception - drug effects ; Oils, Volatile - chemistry ; Oils, Volatile - pharmacology ; Oils, Volatile - therapeutic use ; Pain - chemically induced ; Pain - diagnosis ; Pain - drug therapy ; Pain Measurement ; Plant Oils - chemistry ; Plant Oils - isolation & purification ; Plant Oils - pharmacology ; Toxicity Tests, Acute</subject><ispartof>Journal of ethnopharmacology, 2020-01, Vol.247, p.112265-112265, Article 112265</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-dffe1e6946d5971d201e07cb79b929425c6e7b3abeeb70aa215a35745aef691f3</citedby><cites>FETCH-LOGICAL-c353t-dffe1e6946d5971d201e07cb79b929425c6e7b3abeeb70aa215a35745aef691f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2019.112265$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31580941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira de Veras, Bruno</creatorcontrib><creatorcontrib>Melo de Oliveira, Maria Betânia</creatorcontrib><creatorcontrib>Granja da Silva Oliveira, Fernanda</creatorcontrib><creatorcontrib>Queiroz dos Santos, Yago</creatorcontrib><creatorcontrib>Saturnino de Oliveira, João Ricardhis</creatorcontrib><creatorcontrib>Lúcia de Menezes Lima, Vera</creatorcontrib><creatorcontrib>Guedes da Silva Almeida, Jackson Roberto</creatorcontrib><creatorcontrib>Maria do Amaral Ferraz Navarro, Daniela</creatorcontrib><creatorcontrib>Ribeiro de Oliveira Farias de Aguiar, Júlio César</creatorcontrib><creatorcontrib>Aguiar, Jaciana dos Santos</creatorcontrib><creatorcontrib>Gorlach-Lira, Krystyna</creatorcontrib><creatorcontrib>Dias de Assis, Caio Rodrigo</creatorcontrib><creatorcontrib>Vanusa da Silva, Márcia</creatorcontrib><creatorcontrib>Catarina de Souza Lopes, Ana</creatorcontrib><title>Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Hymenaea cangaceira Pinto, Mansano & Azevedo (Fabaceae) is a Brazilian medicinal plant widely known as “Jatobá”. In folk medicine, it is used to treat infections, respiratory problems, rheumatism, antitumoral, inflammation and pain, however, no activity has been scientifically validated.
This study investigated chemical composition of essential oil from Hymenaea cangaceira (EOHc), antimicrobial, antinociceptive and antioxidant activities besides protection against DNA damage and hemolysis.
The essential oil was obtained by hydrodistillation, and characterized by GC-MS and GC-FID. The evaluation of antimicrobial activity was performed by microdilution method. The evaluation of the antioxidant activity was performed using the radicals DPPH, ABTS, O2- and OH-, and the protection of DNA damage using plasmid pBR322. Different experimental models were used to evaluate the antinociceptive effect (acetic acid and formalin), and evaluate the mechanisms of action involved with pharmacological antagonists (naloxone, atropine and gibenclamide) in mice. The essential oil was evaluated for hemolysis on human erythrocytes.
The extraction of EOHc showed a yield of 0.18% on a dry basis, presenting high content of hydrocarbon sesquiterpenes (79.04%), high antioxidant activity and protect DNA from damage, besides presenting antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria in vitro. It was found that the essential oil had no acute toxicity in mice up to 5000 mg/kg oral administration (o.a.), in addition to no hemolysis on human erythrocytes. The reduction of antinociceptive activity was 75%, with the opioid system as the mechanism of action.
Our results validate the main activities by the traditional use attributed to H. cangaceira for antimicrobial and analgesic activity. In addition, the oil has a potent antioxidant activity, protecting the body against oxidative stress damage, adding new value to an endemic species not known to the industry.
[Display omitted]</description><subject>Acetic Acid - toxicity</subject><subject>Analgesics - chemistry</subject><subject>Analgesics - isolation & purification</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial activity</subject><subject>Antinociceptive</subject><subject>Antioxidant activity</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Brazil</subject><subject>Disease Models, Animal</subject><subject>Drug Evaluation, Preclinical</subject><subject>Essential oil</subject><subject>Ethanol - chemistry</subject><subject>Ethnopharmacology</subject><subject>Fabaceae</subject><subject>Formaldehyde - toxicity</subject><subject>Humans</subject><subject>Hymenaea - chemistry</subject><subject>Medicine, Traditional - methods</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Nociception - drug effects</subject><subject>Oils, Volatile - chemistry</subject><subject>Oils, Volatile - pharmacology</subject><subject>Oils, Volatile - therapeutic use</subject><subject>Pain - chemically induced</subject><subject>Pain - diagnosis</subject><subject>Pain - drug therapy</subject><subject>Pain Measurement</subject><subject>Plant Oils - chemistry</subject><subject>Plant Oils - isolation & purification</subject><subject>Plant Oils - pharmacology</subject><subject>Toxicity Tests, Acute</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFu1DAUtBCILoUP4IJ8QkVqFjtO4g2clhVQpCI4wNl6cV7oWyV2sJMV7S_yUzi7hSOnpzeeGdszjD2XYi2FrF7v13sc17mQ9VrKPK_KB2wlNzrPdKnVQ7YSSm-yjS7kGXsS414IoWUhHrMzJcuNqAu5Yr93NziQhZ5bP4w-0kTecXAtxwP0MxxX3_HpBhM6kfOWLI4THfDyCPhf1KZ5lCx7Mgu-oWSIXYd2iosaY8R0lkBPPe-CH_jV7YAOELgF9wMsUgB-8ZXc5C_5Z3ARnOcv-fYOD9j6V9zBciWfPH8X4I76N3y7YHNIngO2ZMnhU_aogz7is_t5zr5_eP9td5Vdf_n4abe9zqwq1ZS16V0Sq7qo2rLWsk35odC20XVT53WRl7ZC3ShoEBstAHJZgip1UQJ2VS07dc4uTr5j8D9njJMZKFrse3Do52hyJWShUr5VosoTNYUSY8DOjIEGCLdGCrN0aPYmdWiWDs2pw6R5cW8_N-lr_xR_S0uEtycCpk8eCIOJltDZFENIiZvW03_s_wCiOLCa</recordid><startdate>20200130</startdate><enddate>20200130</enddate><creator>Oliveira de Veras, Bruno</creator><creator>Melo de Oliveira, Maria Betânia</creator><creator>Granja da Silva Oliveira, Fernanda</creator><creator>Queiroz dos Santos, Yago</creator><creator>Saturnino de Oliveira, João Ricardhis</creator><creator>Lúcia de Menezes Lima, Vera</creator><creator>Guedes da Silva Almeida, Jackson Roberto</creator><creator>Maria do Amaral Ferraz Navarro, Daniela</creator><creator>Ribeiro de Oliveira Farias de Aguiar, Júlio César</creator><creator>Aguiar, Jaciana dos Santos</creator><creator>Gorlach-Lira, Krystyna</creator><creator>Dias de Assis, Caio Rodrigo</creator><creator>Vanusa da Silva, Márcia</creator><creator>Catarina de Souza Lopes, Ana</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200130</creationdate><title>Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine</title><author>Oliveira de Veras, Bruno ; Melo de Oliveira, Maria Betânia ; Granja da Silva Oliveira, Fernanda ; Queiroz dos Santos, Yago ; Saturnino de Oliveira, João Ricardhis ; Lúcia de Menezes Lima, Vera ; Guedes da Silva Almeida, Jackson Roberto ; Maria do Amaral Ferraz Navarro, Daniela ; Ribeiro de Oliveira Farias de Aguiar, Júlio César ; Aguiar, Jaciana dos Santos ; Gorlach-Lira, Krystyna ; Dias de Assis, Caio Rodrigo ; Vanusa da Silva, Márcia ; Catarina de Souza Lopes, Ana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-dffe1e6946d5971d201e07cb79b929425c6e7b3abeeb70aa215a35745aef691f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetic Acid - toxicity</topic><topic>Analgesics - chemistry</topic><topic>Analgesics - isolation & purification</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antimicrobial activity</topic><topic>Antinociceptive</topic><topic>Antioxidant activity</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Brazil</topic><topic>Disease Models, Animal</topic><topic>Drug Evaluation, Preclinical</topic><topic>Essential oil</topic><topic>Ethanol - chemistry</topic><topic>Ethnopharmacology</topic><topic>Fabaceae</topic><topic>Formaldehyde - toxicity</topic><topic>Humans</topic><topic>Hymenaea - chemistry</topic><topic>Medicine, Traditional - methods</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Nociception - drug effects</topic><topic>Oils, Volatile - chemistry</topic><topic>Oils, Volatile - pharmacology</topic><topic>Oils, Volatile - therapeutic use</topic><topic>Pain - chemically induced</topic><topic>Pain - diagnosis</topic><topic>Pain - drug therapy</topic><topic>Pain Measurement</topic><topic>Plant Oils - chemistry</topic><topic>Plant Oils - isolation & purification</topic><topic>Plant Oils - pharmacology</topic><topic>Toxicity Tests, Acute</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira de Veras, Bruno</creatorcontrib><creatorcontrib>Melo de Oliveira, Maria Betânia</creatorcontrib><creatorcontrib>Granja da Silva Oliveira, Fernanda</creatorcontrib><creatorcontrib>Queiroz dos Santos, Yago</creatorcontrib><creatorcontrib>Saturnino de Oliveira, João Ricardhis</creatorcontrib><creatorcontrib>Lúcia de Menezes Lima, Vera</creatorcontrib><creatorcontrib>Guedes da Silva Almeida, Jackson Roberto</creatorcontrib><creatorcontrib>Maria do Amaral Ferraz Navarro, Daniela</creatorcontrib><creatorcontrib>Ribeiro de Oliveira Farias de Aguiar, Júlio César</creatorcontrib><creatorcontrib>Aguiar, Jaciana dos Santos</creatorcontrib><creatorcontrib>Gorlach-Lira, Krystyna</creatorcontrib><creatorcontrib>Dias de Assis, Caio Rodrigo</creatorcontrib><creatorcontrib>Vanusa da Silva, Márcia</creatorcontrib><creatorcontrib>Catarina de Souza Lopes, Ana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira de Veras, Bruno</au><au>Melo de Oliveira, Maria Betânia</au><au>Granja da Silva Oliveira, Fernanda</au><au>Queiroz dos Santos, Yago</au><au>Saturnino de Oliveira, João Ricardhis</au><au>Lúcia de Menezes Lima, Vera</au><au>Guedes da Silva Almeida, Jackson Roberto</au><au>Maria do Amaral Ferraz Navarro, Daniela</au><au>Ribeiro de Oliveira Farias de Aguiar, Júlio César</au><au>Aguiar, Jaciana dos Santos</au><au>Gorlach-Lira, Krystyna</au><au>Dias de Assis, Caio Rodrigo</au><au>Vanusa da Silva, Márcia</au><au>Catarina de Souza Lopes, Ana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2020-01-30</date><risdate>2020</risdate><volume>247</volume><spage>112265</spage><epage>112265</epage><pages>112265-112265</pages><artnum>112265</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Hymenaea cangaceira Pinto, Mansano & Azevedo (Fabaceae) is a Brazilian medicinal plant widely known as “Jatobá”. In folk medicine, it is used to treat infections, respiratory problems, rheumatism, antitumoral, inflammation and pain, however, no activity has been scientifically validated.
This study investigated chemical composition of essential oil from Hymenaea cangaceira (EOHc), antimicrobial, antinociceptive and antioxidant activities besides protection against DNA damage and hemolysis.
The essential oil was obtained by hydrodistillation, and characterized by GC-MS and GC-FID. The evaluation of antimicrobial activity was performed by microdilution method. The evaluation of the antioxidant activity was performed using the radicals DPPH, ABTS, O2- and OH-, and the protection of DNA damage using plasmid pBR322. Different experimental models were used to evaluate the antinociceptive effect (acetic acid and formalin), and evaluate the mechanisms of action involved with pharmacological antagonists (naloxone, atropine and gibenclamide) in mice. The essential oil was evaluated for hemolysis on human erythrocytes.
The extraction of EOHc showed a yield of 0.18% on a dry basis, presenting high content of hydrocarbon sesquiterpenes (79.04%), high antioxidant activity and protect DNA from damage, besides presenting antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria in vitro. It was found that the essential oil had no acute toxicity in mice up to 5000 mg/kg oral administration (o.a.), in addition to no hemolysis on human erythrocytes. The reduction of antinociceptive activity was 75%, with the opioid system as the mechanism of action.
Our results validate the main activities by the traditional use attributed to H. cangaceira for antimicrobial and analgesic activity. In addition, the oil has a potent antioxidant activity, protecting the body against oxidative stress damage, adding new value to an endemic species not known to the industry.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31580941</pmid><doi>10.1016/j.jep.2019.112265</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2020-01, Vol.247, p.112265-112265, Article 112265 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetic Acid - toxicity Analgesics - chemistry Analgesics - isolation & purification Analgesics - pharmacology Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antimicrobial activity Antinociceptive Antioxidant activity Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Brazil Disease Models, Animal Drug Evaluation, Preclinical Essential oil Ethanol - chemistry Ethnopharmacology Fabaceae Formaldehyde - toxicity Humans Hymenaea - chemistry Medicine, Traditional - methods Mice Microbial Sensitivity Tests Nociception - drug effects Oils, Volatile - chemistry Oils, Volatile - pharmacology Oils, Volatile - therapeutic use Pain - chemically induced Pain - diagnosis Pain - drug therapy Pain Measurement Plant Oils - chemistry Plant Oils - isolation & purification Plant Oils - pharmacology Toxicity Tests, Acute |
| title | Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine |
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