Fructus Psoraleae–Induced Severe Liver Injury and Treatment With Two Artificial Liver Support Systems: A Case Series Study
To describe the clinical features and outcomes of patients with suspected Fructus Psoraleae (FP)–induced severe liver injury who underwent treatment with two artificial liver support systems (ALSSs). The cases of 12 patients with severe liver injury by FP were enrolled. We evaluated the tolerability...
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| Veröffentlicht in: | Therapeutic apheresis and dialysis 2020-06, Vol.24 (3), p.324-332 |
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| creator | Rong, Jiangcheng Xie, Zhongyang Chen, Ermei Ma, Shanshan Zhang, Sainan Zhao, Yalei Xu, Xiaowei Li, Lanjuan |
| description | To describe the clinical features and outcomes of patients with suspected Fructus Psoraleae (FP)–induced severe liver injury who underwent treatment with two artificial liver support systems (ALSSs). The cases of 12 patients with severe liver injury by FP were enrolled. We evaluated the tolerability of, and changes in biochemical parameters after treatment with plasma exchange combined with hemofiltration and double plasma molecular absorption system, and 6‐month follow‐up information were collected. The median age of the 12 patients was 60 years and nine (75%) patients were females. All patients had jaundice as the initial symptom. Two ALSS types were used to treat the patients. The group that underwent plasma exchange combined with hemofiltration showed remarkable improvements in ALT, AST, total bilirubin (TB), GGT and international normalized ratio levels (AST, TB, international normalized ratio, P |
| doi_str_mv | 10.1111/1744-9987.13438 |
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The cases of 12 patients with severe liver injury by FP were enrolled. We evaluated the tolerability of, and changes in biochemical parameters after treatment with plasma exchange combined with hemofiltration and double plasma molecular absorption system, and 6‐month follow‐up information were collected. The median age of the 12 patients was 60 years and nine (75%) patients were females. All patients had jaundice as the initial symptom. Two ALSS types were used to treat the patients. The group that underwent plasma exchange combined with hemofiltration showed remarkable improvements in ALT, AST, total bilirubin (TB), GGT and international normalized ratio levels (AST, TB, international normalized ratio, P < 0.01; ALT, GGT, P < 0.05), and the levels of AST, ALP, TB, and total bile acid decreased significantly in the double plasma molecular absorption system group after treatment (TB, P < 0.01; AST, ALP, total bile acid P < 0.05). During 6 months of follow‐up, two patients died, two became chronic, and eight recovered to normal. FP can cause clinically severe liver injury, characterized by gastrointestinal symptoms and jaundice, which can lead to death or become chronic. Both ALSSs were safe and well tolerated in drug‐induced liver injury patients. After ALSS treatment, the levels of biochemical indicators of liver function improved significantly, indicating that ALSS might be beneficial for patients with severe drug‐induced liver injury.</description><identifier>ISSN: 1744-9979</identifier><identifier>EISSN: 1744-9987</identifier><identifier>DOI: 10.1111/1744-9987.13438</identifier><identifier>PMID: 31577858</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Artificial liver support system ; Drug‐induced liver injury ; Fructus Psoraleae</subject><ispartof>Therapeutic apheresis and dialysis, 2020-06, Vol.24 (3), p.324-332</ispartof><rights>2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy</rights><rights>2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3678-a68e603c6c03730cbad0b64834aed0d368b30c2c291aad603a2785e9a43c427b3</citedby><cites>FETCH-LOGICAL-c3678-a68e603c6c03730cbad0b64834aed0d368b30c2c291aad603a2785e9a43c427b3</cites><orcidid>0000-0001-6945-0593</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1744-9987.13438$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1744-9987.13438$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31577858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rong, Jiangcheng</creatorcontrib><creatorcontrib>Xie, Zhongyang</creatorcontrib><creatorcontrib>Chen, Ermei</creatorcontrib><creatorcontrib>Ma, Shanshan</creatorcontrib><creatorcontrib>Zhang, Sainan</creatorcontrib><creatorcontrib>Zhao, Yalei</creatorcontrib><creatorcontrib>Xu, Xiaowei</creatorcontrib><creatorcontrib>Li, Lanjuan</creatorcontrib><title>Fructus Psoraleae–Induced Severe Liver Injury and Treatment With Two Artificial Liver Support Systems: A Case Series Study</title><title>Therapeutic apheresis and dialysis</title><addtitle>Ther Apher Dial</addtitle><description>To describe the clinical features and outcomes of patients with suspected Fructus Psoraleae (FP)–induced severe liver injury who underwent treatment with two artificial liver support systems (ALSSs). The cases of 12 patients with severe liver injury by FP were enrolled. We evaluated the tolerability of, and changes in biochemical parameters after treatment with plasma exchange combined with hemofiltration and double plasma molecular absorption system, and 6‐month follow‐up information were collected. The median age of the 12 patients was 60 years and nine (75%) patients were females. All patients had jaundice as the initial symptom. Two ALSS types were used to treat the patients. The group that underwent plasma exchange combined with hemofiltration showed remarkable improvements in ALT, AST, total bilirubin (TB), GGT and international normalized ratio levels (AST, TB, international normalized ratio, P < 0.01; ALT, GGT, P < 0.05), and the levels of AST, ALP, TB, and total bile acid decreased significantly in the double plasma molecular absorption system group after treatment (TB, P < 0.01; AST, ALP, total bile acid P < 0.05). During 6 months of follow‐up, two patients died, two became chronic, and eight recovered to normal. FP can cause clinically severe liver injury, characterized by gastrointestinal symptoms and jaundice, which can lead to death or become chronic. Both ALSSs were safe and well tolerated in drug‐induced liver injury patients. After ALSS treatment, the levels of biochemical indicators of liver function improved significantly, indicating that ALSS might be beneficial for patients with severe drug‐induced liver injury.</description><subject>Artificial liver support system</subject><subject>Drug‐induced liver injury</subject><subject>Fructus Psoraleae</subject><issn>1744-9979</issn><issn>1744-9987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKAzEUQIMovtfuJEs31cwkM5NxV4qPQkGhFZchk9xiZB41D8uAC__BP_RLTG3t1mxuuJwcyEHoLCGXSTxXScHYoCx5cZlQRvkOOtxudrf3ojxAR869EpKmjNJ9dECTrCh4xg_Rx60NygeHH11nZQ0Svj-_xq0OCjSewjtYwBMTBx63r8H2WLYazyxI30Dr8bPxL3i27PDQejM3ysh6g0_DYtFZj6e989C4azzEI-kgOq0Bh6c-6P4E7c1l7eB0M4_R0-3NbHQ_mDzcjUfDyUDRvOADmXPICVW5IrSgRFVSkypnnDIJmmia8ypuU5WWiZQ6kjKNn4NSMqpYWlT0GF2svQvbvQVwXjTGKahr2UIXnEgpIVmZ8YxF9GqNKts5Z2EuFtY00vYiIWKVXKyiilVg8Zs8vjjfyEPVgN7yf40jkK2Bpamh_88nZsPHtfgHtYmMzA</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Rong, Jiangcheng</creator><creator>Xie, Zhongyang</creator><creator>Chen, Ermei</creator><creator>Ma, Shanshan</creator><creator>Zhang, Sainan</creator><creator>Zhao, Yalei</creator><creator>Xu, Xiaowei</creator><creator>Li, Lanjuan</creator><general>John Wiley & Sons Australia, Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6945-0593</orcidid></search><sort><creationdate>202006</creationdate><title>Fructus Psoraleae–Induced Severe Liver Injury and Treatment With Two Artificial Liver Support Systems: A Case Series Study</title><author>Rong, Jiangcheng ; Xie, Zhongyang ; Chen, Ermei ; Ma, Shanshan ; Zhang, Sainan ; Zhao, Yalei ; Xu, Xiaowei ; Li, Lanjuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3678-a68e603c6c03730cbad0b64834aed0d368b30c2c291aad603a2785e9a43c427b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Artificial liver support system</topic><topic>Drug‐induced liver injury</topic><topic>Fructus Psoraleae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rong, Jiangcheng</creatorcontrib><creatorcontrib>Xie, Zhongyang</creatorcontrib><creatorcontrib>Chen, Ermei</creatorcontrib><creatorcontrib>Ma, Shanshan</creatorcontrib><creatorcontrib>Zhang, Sainan</creatorcontrib><creatorcontrib>Zhao, Yalei</creatorcontrib><creatorcontrib>Xu, Xiaowei</creatorcontrib><creatorcontrib>Li, Lanjuan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic apheresis and dialysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rong, Jiangcheng</au><au>Xie, Zhongyang</au><au>Chen, Ermei</au><au>Ma, Shanshan</au><au>Zhang, Sainan</au><au>Zhao, Yalei</au><au>Xu, Xiaowei</au><au>Li, Lanjuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fructus Psoraleae–Induced Severe Liver Injury and Treatment With Two Artificial Liver Support Systems: A Case Series Study</atitle><jtitle>Therapeutic apheresis and dialysis</jtitle><addtitle>Ther Apher Dial</addtitle><date>2020-06</date><risdate>2020</risdate><volume>24</volume><issue>3</issue><spage>324</spage><epage>332</epage><pages>324-332</pages><issn>1744-9979</issn><eissn>1744-9987</eissn><abstract>To describe the clinical features and outcomes of patients with suspected Fructus Psoraleae (FP)–induced severe liver injury who underwent treatment with two artificial liver support systems (ALSSs). The cases of 12 patients with severe liver injury by FP were enrolled. We evaluated the tolerability of, and changes in biochemical parameters after treatment with plasma exchange combined with hemofiltration and double plasma molecular absorption system, and 6‐month follow‐up information were collected. The median age of the 12 patients was 60 years and nine (75%) patients were females. All patients had jaundice as the initial symptom. Two ALSS types were used to treat the patients. The group that underwent plasma exchange combined with hemofiltration showed remarkable improvements in ALT, AST, total bilirubin (TB), GGT and international normalized ratio levels (AST, TB, international normalized ratio, P < 0.01; ALT, GGT, P < 0.05), and the levels of AST, ALP, TB, and total bile acid decreased significantly in the double plasma molecular absorption system group after treatment (TB, P < 0.01; AST, ALP, total bile acid P < 0.05). During 6 months of follow‐up, two patients died, two became chronic, and eight recovered to normal. FP can cause clinically severe liver injury, characterized by gastrointestinal symptoms and jaundice, which can lead to death or become chronic. Both ALSSs were safe and well tolerated in drug‐induced liver injury patients. After ALSS treatment, the levels of biochemical indicators of liver function improved significantly, indicating that ALSS might be beneficial for patients with severe drug‐induced liver injury.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>31577858</pmid><doi>10.1111/1744-9987.13438</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6945-0593</orcidid></addata></record> |
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| subjects | Artificial liver support system Drug‐induced liver injury Fructus Psoraleae |
| title | Fructus Psoraleae–Induced Severe Liver Injury and Treatment With Two Artificial Liver Support Systems: A Case Series Study |
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