Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial

Purpose Myocardial dysfunction is common in sepsis but optimal treatment strategies are unclear. The inodilator, levosimendan was suggested as a possible therapy; however, the levosimendan to prevent acute organ dysfunction in Sepsis (LeoPARDS) trial found it to have no benefit in reducing organ dys...

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Veröffentlicht in:	Intensive care medicine 2019-10, Vol.45 (10), p.1392-1400
Hauptverfasser:	Antcliffe, David B., Santhakumaran, Shalini, Orme, Robert M. L., Ward, Josie K., Al-Beidh, Farah, O’Dea, Kieran, Perkins, Gavin D., Singer, Mervyn, McAuley, Daniel F., Mason, Alexina J., Cross, Mary, Ashby, Deborah, Gordon, Anthony C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Anesthesiology Biochemistry Biomarkers Biomarkers - analysis Biomarkers - blood Brain Brain natriuretic peptide Calcium-binding protein Cardiac patients Cardiology Care and treatment Chemokine CCL2 - analysis Chemokine CCL2 - blood Critical Care Medicine Double-Blind Method Emergency Medicine Female Health aspects Heart Diseases - blood Heart Diseases - drug therapy Heart Diseases - physiopathology HSP90 Heat-Shock Proteins - analysis HSP90 Heat-Shock Proteins - blood Humans Infection Inflammation Intensive Intensive care Intensive Care Units - organization & administration Intensive Care Units - statistics & numerical data Interleukin-10 - analysis Interleukin-10 - blood Interleukin-6 - analysis Interleukin-6 - blood Interleukin-8 - analysis Interleukin-8 - blood Male Medical colleges Medicine Medicine & Public Health Middle Aged Mortality Natriuretic Peptide, Brain - analysis Natriuretic Peptide, Brain - blood Natriuretic peptides Organ Dysfunction Scores Original Pain Medicine Pediatrics Peptide Fragments - analysis Peptide Fragments - blood Pneumology/Respiratory System Prognosis Sepsis Septic shock Shock, Septic - complications Shock, Septic - drug therapy Simendan - pharmacology Simendan - therapeutic use Statistical analysis Subgroups Troponin Troponin I Troponin I - analysis Troponin I - blood United Kingdom
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