The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML

To date, only one subtype of acute myeloid leukemia (AML), acute promyelocytic leukemia (APL) can be effectively treated by differentiation therapy utilizing all-trans retinoic acid (ATRA). Non-APL AMLs are resistant to ATRA. Here we demonstrate that the acetyltransferase GCN5 contributes to ATRA re...

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Veröffentlicht in:	Leukemia 2019-11, Vol.33 (11), p.2628-2639
Hauptverfasser:	Kahl, Melanie, Brioli, Annamaria, Bens, Martin, Perner, Florian, Kresinsky, Anne, Schnetzke, Ulf, Hinze, Anna, Sbirkov, Yordan, Stengel, Sven, Simonetti, Giorgia, Martinelli, Giovanni, Petrie, Kevin, Zelent, Arthur, Böhmer, Frank-Dietmar, Groth, Marco, Ernst, Thomas, Heidel, Florian H., Scholl, Sebastian, Hochhaus, Andreas, Schenk, Tino
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/31 13/89 38 38/109 38/39 38/89 38/91 631/67/1059/602 692/308/575 Acetylation Acetyltransferase Acute myeloid leukemia Acute promyeloid leukemia Apoptosis Bone Marrow - metabolism Cancer Research Cell Differentiation Cell Line, Tumor Cell Membrane - metabolism Critical Care Medicine Cytogenetics Differentiation Drug Resistance, Neoplasm Epigenesis, Genetic Epigenetics Gene expression Gene mutations Genetic research Genotype HEK293 Cells Hematology Histone Demethylases - antagonists & inhibitors Histones - chemistry HL-60 Cells Humans Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Promyelocytic, Acute - drug therapy Leukocytes, Mononuclear - cytology Lysine Medicine Medicine & Public Health Myeloid leukemia Oncology p300-CBP Transcription Factors - metabolism Promyeloid leukemia Retinoic acid Therapeutic applications Therapy Tretinoin Tretinoin - pharmacology
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