Alveolar Ridge Preservation Using Autologous Demineralized Tooth Matrix and Platelet-Rich Fibrin Versus Platelet-Rich Fibrin Alone: A Split-Mouth Randomized Controlled Clinical Trial

To assess the potential of using autologous demineralized tooth matrix (aDTM) in combination with platelet-rich fibrin (PRF) membrane (aDTM/PRF) or PRF membrane alone (control) to preserve the ridge dimension and facilitate bone healing after tooth extraction. Forty premolar sockets were assigned to either the aDTM/PRF or control group. Horizontal and vertical ridge changes were evaluated at the baseline 2, 4, 6, and 8 weeks using cast-based and periapical radiographs. aDTM was well tolerated in all sites without incidences of postoperative complication. The change in horizontal ridge width was significantly greater in the control compared with the aDTM/PRF group. The overall vertical marginal bone resorption on the mesial, distal, and central site in the aDTM/PRF group was not statistically different from the control group. During the first 6 weeks, the bone healing density in the aDTM/PRF group was significantly higher than that of the control group, then it converged at week 8. Application of aDTM with PRF membrane is useful for ridge preservation by reducing the horizontal ridge collapse and promoting bone healing as shown clinically and radiographically.