Severity and depression can impact quality of life in patients with myasthenia gravis
Background The revised 15‐item Myasthenia Gravis (MG) Quality of Life Questionnaire (MGQoL15R) is a validated scale of quality of life in patients with MG. We aimed to study the factors causing the variability within the Arabic version of the MGQoL15R (MGQoL15R‐A). Method A standardized questionnair...
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| Veröffentlicht in: | Muscle & nerve 2020-01, Vol.61 (1), p.69-73 |
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| creator | Alanazy, Mohammed H. Binabbad, Rahaf S. Alromaih, Norah I. Almansour, Raghad A. Alanazi, Shahad N. Alhamdi, Malak F. Alazwary, Naael Muayqil, Taim |
| description | Background
The revised 15‐item Myasthenia Gravis (MG) Quality of Life Questionnaire (MGQoL15R) is a validated scale of quality of life in patients with MG. We aimed to study the factors causing the variability within the Arabic version of the MGQoL15R (MGQoL15R‐A).
Method
A standardized questionnaire was completed by 118 patients. Correlations and hierarchical regression analyses were used to assess the contribution of sociodemographic variables, clinical factors, Patient Health Questionnaire‐9 (PHQ9‐A), and Generalized Anxiety Disorder‐7 (GAD7‐A) to the variability in the MGQoL15R‐A.
Results
The MGQoL15R‐A was highly correlated with PHQ9‐A (r = 0.76), and moderately correlated with GAD7‐A (r = 0.52). Clinical factors and PHQ9‐A independently explained 30.4% and 34.5% of the variability, respectively. Among the clinical factors, uncontrolled MG status, relapse within the past year, and a higher number of current MG therapies were significantly associated with a higher MGQoL15R‐A score.
Conclusions
MG severity and depressive symptoms (measured by PHQ9‐A) can affect the MGQoL15R‐A score. |
| doi_str_mv | 10.1002/mus.26719 |
| format | Article |
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The revised 15‐item Myasthenia Gravis (MG) Quality of Life Questionnaire (MGQoL15R) is a validated scale of quality of life in patients with MG. We aimed to study the factors causing the variability within the Arabic version of the MGQoL15R (MGQoL15R‐A).
Method
A standardized questionnaire was completed by 118 patients. Correlations and hierarchical regression analyses were used to assess the contribution of sociodemographic variables, clinical factors, Patient Health Questionnaire‐9 (PHQ9‐A), and Generalized Anxiety Disorder‐7 (GAD7‐A) to the variability in the MGQoL15R‐A.
Results
The MGQoL15R‐A was highly correlated with PHQ9‐A (r = 0.76), and moderately correlated with GAD7‐A (r = 0.52). Clinical factors and PHQ9‐A independently explained 30.4% and 34.5% of the variability, respectively. Among the clinical factors, uncontrolled MG status, relapse within the past year, and a higher number of current MG therapies were significantly associated with a higher MGQoL15R‐A score.
Conclusions
MG severity and depressive symptoms (measured by PHQ9‐A) can affect the MGQoL15R‐A score.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26719</identifier><identifier>PMID: 31573094</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Anxiety ; Anxiety Disorders - complications ; Anxiety Disorders - psychology ; Arabic ; Arabs ; Correlation analysis ; depression ; Depression - complications ; Depression - psychology ; Female ; Health Status ; Humans ; Male ; Mental depression ; MGQoL15R ; MGQoL15R‐A ; Middle Aged ; Myasthenia ; Myasthenia gravis ; Myasthenia Gravis - psychology ; Neuromuscular junctions ; Quality of Life ; Questionnaires ; Regression analysis ; Reproducibility of Results ; Socioeconomic Factors ; Surveys and Questionnaires ; Translations ; Variability</subject><ispartof>Muscle & nerve, 2020-01, Vol.61 (1), p.69-73</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-ced95e8398a45c332d4e386d27f5dbee415351ac4a88ff57d38fa0931318a6633</citedby><cites>FETCH-LOGICAL-c3539-ced95e8398a45c332d4e386d27f5dbee415351ac4a88ff57d38fa0931318a6633</cites><orcidid>0000-0001-5177-8283</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26719$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26719$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31573094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alanazy, Mohammed H.</creatorcontrib><creatorcontrib>Binabbad, Rahaf S.</creatorcontrib><creatorcontrib>Alromaih, Norah I.</creatorcontrib><creatorcontrib>Almansour, Raghad A.</creatorcontrib><creatorcontrib>Alanazi, Shahad N.</creatorcontrib><creatorcontrib>Alhamdi, Malak F.</creatorcontrib><creatorcontrib>Alazwary, Naael</creatorcontrib><creatorcontrib>Muayqil, Taim</creatorcontrib><title>Severity and depression can impact quality of life in patients with myasthenia gravis</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Background
The revised 15‐item Myasthenia Gravis (MG) Quality of Life Questionnaire (MGQoL15R) is a validated scale of quality of life in patients with MG. We aimed to study the factors causing the variability within the Arabic version of the MGQoL15R (MGQoL15R‐A).
Method
A standardized questionnaire was completed by 118 patients. Correlations and hierarchical regression analyses were used to assess the contribution of sociodemographic variables, clinical factors, Patient Health Questionnaire‐9 (PHQ9‐A), and Generalized Anxiety Disorder‐7 (GAD7‐A) to the variability in the MGQoL15R‐A.
Results
The MGQoL15R‐A was highly correlated with PHQ9‐A (r = 0.76), and moderately correlated with GAD7‐A (r = 0.52). Clinical factors and PHQ9‐A independently explained 30.4% and 34.5% of the variability, respectively. Among the clinical factors, uncontrolled MG status, relapse within the past year, and a higher number of current MG therapies were significantly associated with a higher MGQoL15R‐A score.
Conclusions
MG severity and depressive symptoms (measured by PHQ9‐A) can affect the MGQoL15R‐A score.</description><subject>Adult</subject><subject>Aged</subject><subject>Anxiety</subject><subject>Anxiety Disorders - complications</subject><subject>Anxiety Disorders - psychology</subject><subject>Arabic</subject><subject>Arabs</subject><subject>Correlation analysis</subject><subject>depression</subject><subject>Depression - complications</subject><subject>Depression - psychology</subject><subject>Female</subject><subject>Health Status</subject><subject>Humans</subject><subject>Male</subject><subject>Mental depression</subject><subject>MGQoL15R</subject><subject>MGQoL15R‐A</subject><subject>Middle Aged</subject><subject>Myasthenia</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - psychology</subject><subject>Neuromuscular junctions</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Reproducibility of Results</subject><subject>Socioeconomic Factors</subject><subject>Surveys and Questionnaires</subject><subject>Translations</subject><subject>Variability</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EtLxDAUhuEgio6jC_-ABNzooprkJE2yFPEGigsdcFcy7akT6c2kVebf22FGF4Krs3l4OXyEHHF2zhkTF_UQz0Wqud0iE86sTqSyZptMGJcmScG-7pH9GN8ZY9ykepfsAVcamJUTMnvGTwy-X1LXFLTALmCMvm1o7hrq687lPf0YXLUSbUkrXyL1De1c77HpI_3y_YLWSxf7BTbe0bfgPn08IDulqyIebu6UzG6uX67ukoen2_ury4ckBwU2ybGwCg1Y46TKAUQhEUxaCF2qYo4ouQLFXS6dMWWpdAGmdMwCB25cmgJMyem624X2Y8DYZ7WPOVaVa7AdYiaEtVpLAWakJ3_oezuEZvwuEyCU5pJpOaqztcpDG2PAMuuCr11YZpxlq62zepVdbT3a401xmNdY_MqfcUdwsQZfvsLl_6Xscfa8Tn4DqvqIVw</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Alanazy, Mohammed H.</creator><creator>Binabbad, Rahaf S.</creator><creator>Alromaih, Norah I.</creator><creator>Almansour, Raghad A.</creator><creator>Alanazi, Shahad N.</creator><creator>Alhamdi, Malak F.</creator><creator>Alazwary, Naael</creator><creator>Muayqil, Taim</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5177-8283</orcidid></search><sort><creationdate>202001</creationdate><title>Severity and depression can impact quality of life in patients with myasthenia gravis</title><author>Alanazy, Mohammed H. ; Binabbad, Rahaf S. ; Alromaih, Norah I. ; Almansour, Raghad A. ; Alanazi, Shahad N. ; Alhamdi, Malak F. ; Alazwary, Naael ; Muayqil, Taim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-ced95e8398a45c332d4e386d27f5dbee415351ac4a88ff57d38fa0931318a6633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anxiety</topic><topic>Anxiety Disorders - complications</topic><topic>Anxiety Disorders - psychology</topic><topic>Arabic</topic><topic>Arabs</topic><topic>Correlation analysis</topic><topic>depression</topic><topic>Depression - complications</topic><topic>Depression - psychology</topic><topic>Female</topic><topic>Health Status</topic><topic>Humans</topic><topic>Male</topic><topic>Mental depression</topic><topic>MGQoL15R</topic><topic>MGQoL15R‐A</topic><topic>Middle Aged</topic><topic>Myasthenia</topic><topic>Myasthenia gravis</topic><topic>Myasthenia Gravis - psychology</topic><topic>Neuromuscular junctions</topic><topic>Quality of Life</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Reproducibility of Results</topic><topic>Socioeconomic Factors</topic><topic>Surveys and Questionnaires</topic><topic>Translations</topic><topic>Variability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alanazy, Mohammed H.</creatorcontrib><creatorcontrib>Binabbad, Rahaf S.</creatorcontrib><creatorcontrib>Alromaih, Norah I.</creatorcontrib><creatorcontrib>Almansour, Raghad A.</creatorcontrib><creatorcontrib>Alanazi, Shahad N.</creatorcontrib><creatorcontrib>Alhamdi, Malak F.</creatorcontrib><creatorcontrib>Alazwary, Naael</creatorcontrib><creatorcontrib>Muayqil, Taim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alanazy, Mohammed H.</au><au>Binabbad, Rahaf S.</au><au>Alromaih, Norah I.</au><au>Almansour, Raghad A.</au><au>Alanazi, Shahad N.</au><au>Alhamdi, Malak F.</au><au>Alazwary, Naael</au><au>Muayqil, Taim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severity and depression can impact quality of life in patients with myasthenia gravis</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2020-01</date><risdate>2020</risdate><volume>61</volume><issue>1</issue><spage>69</spage><epage>73</epage><pages>69-73</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Background
The revised 15‐item Myasthenia Gravis (MG) Quality of Life Questionnaire (MGQoL15R) is a validated scale of quality of life in patients with MG. We aimed to study the factors causing the variability within the Arabic version of the MGQoL15R (MGQoL15R‐A).
Method
A standardized questionnaire was completed by 118 patients. Correlations and hierarchical regression analyses were used to assess the contribution of sociodemographic variables, clinical factors, Patient Health Questionnaire‐9 (PHQ9‐A), and Generalized Anxiety Disorder‐7 (GAD7‐A) to the variability in the MGQoL15R‐A.
Results
The MGQoL15R‐A was highly correlated with PHQ9‐A (r = 0.76), and moderately correlated with GAD7‐A (r = 0.52). Clinical factors and PHQ9‐A independently explained 30.4% and 34.5% of the variability, respectively. Among the clinical factors, uncontrolled MG status, relapse within the past year, and a higher number of current MG therapies were significantly associated with a higher MGQoL15R‐A score.
Conclusions
MG severity and depressive symptoms (measured by PHQ9‐A) can affect the MGQoL15R‐A score.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31573094</pmid><doi>10.1002/mus.26719</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-5177-8283</orcidid></addata></record> |
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| ispartof | Muscle & nerve, 2020-01, Vol.61 (1), p.69-73 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged Anxiety Anxiety Disorders - complications Anxiety Disorders - psychology Arabic Arabs Correlation analysis depression Depression - complications Depression - psychology Female Health Status Humans Male Mental depression MGQoL15R MGQoL15R‐A Middle Aged Myasthenia Myasthenia gravis Myasthenia Gravis - psychology Neuromuscular junctions Quality of Life Questionnaires Regression analysis Reproducibility of Results Socioeconomic Factors Surveys and Questionnaires Translations Variability |
| title | Severity and depression can impact quality of life in patients with myasthenia gravis |
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