Dyskinesia‐inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease
Background Acute dyskinesias elicited by STN‐DBS, here referred to as stimulation‐induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation‐induced dyskinesias can guide DBS programming. Objectives Here, we characterized stimulation‐induced dyskines...
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| Veröffentlicht in: | Movement disorders 2019-11, Vol.34 (11), p.1728-1734 |
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| creator | Bouthour, Walid Béreau, Matthieu Kibleur, Astrid Zacharia, André Tomkova Chaoui, Emilie Fleury, Vanessa Benis, Damien Momjian, Shahan Bally, Julien Lüscher, Christian Krack, Paul Burkhard, Pierre R. |
| description | Background
Acute dyskinesias elicited by STN‐DBS, here referred to as stimulation‐induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation‐induced dyskinesias can guide DBS programming.
Objectives
Here, we characterized stimulation‐induced dyskinesias clinically and anatomically. We then tested whether dyskinesia‐inducing contacts could be effectively programmed using independent current source technology.
Methods
We characterized stimulation‐induced dyskinesias with directional and ring stimulation retrospectively in 20 patients. We then localized dyskinesia‐inducing contacts by imaging coregistration and eventually programmed those contacts.
Results
We elicited dyskinesias in half of our patients. Dyskinesia‐inducing contacts were mainly directional and were all located ventrally within the dorsolateral motor STN. When these dyskinesia‐inducing contacts were programmed using independent current source technology, dyskinesia disappeared and robust antibradykinetic effects were obtained.
Conclusion
We confirm that stimulation‐induced dyskinesias are helpful clinical observations, which may guide programming of directional STN‐DBS in PD. © 2019 International Parkinson and Movement Disorder Society |
| doi_str_mv | 10.1002/mds.27853 |
| format | Article |
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Acute dyskinesias elicited by STN‐DBS, here referred to as stimulation‐induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation‐induced dyskinesias can guide DBS programming.
Objectives
Here, we characterized stimulation‐induced dyskinesias clinically and anatomically. We then tested whether dyskinesia‐inducing contacts could be effectively programmed using independent current source technology.
Methods
We characterized stimulation‐induced dyskinesias with directional and ring stimulation retrospectively in 20 patients. We then localized dyskinesia‐inducing contacts by imaging coregistration and eventually programmed those contacts.
Results
We elicited dyskinesias in half of our patients. Dyskinesia‐inducing contacts were mainly directional and were all located ventrally within the dorsolateral motor STN. When these dyskinesia‐inducing contacts were programmed using independent current source technology, dyskinesia disappeared and robust antibradykinetic effects were obtained.
Conclusion
We confirm that stimulation‐induced dyskinesias are helpful clinical observations, which may guide programming of directional STN‐DBS in PD. © 2019 International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.27853</identifier><identifier>PMID: 31571277</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>deep brain stimulation ; directional ; Dyskinesia ; Movement disorders ; Neurodegenerative diseases ; Parkinson's disease ; stimulation‐induced dyskinesia ; subthalamic nucleus</subject><ispartof>Movement disorders, 2019-11, Vol.34 (11), p.1728-1734</ispartof><rights>2019 International Parkinson and Movement Disorder Society</rights><rights>2019 International Parkinson and Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4193-82e0dd98eecdcfd4d17de183f9ae1d16c3580ee153577f47b22454b619b542a13</citedby><cites>FETCH-LOGICAL-c4193-82e0dd98eecdcfd4d17de183f9ae1d16c3580ee153577f47b22454b619b542a13</cites><orcidid>0000-0003-3877-4127 ; 0000-0003-0769-0289</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.27853$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.27853$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31571277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouthour, Walid</creatorcontrib><creatorcontrib>Béreau, Matthieu</creatorcontrib><creatorcontrib>Kibleur, Astrid</creatorcontrib><creatorcontrib>Zacharia, André</creatorcontrib><creatorcontrib>Tomkova Chaoui, Emilie</creatorcontrib><creatorcontrib>Fleury, Vanessa</creatorcontrib><creatorcontrib>Benis, Damien</creatorcontrib><creatorcontrib>Momjian, Shahan</creatorcontrib><creatorcontrib>Bally, Julien</creatorcontrib><creatorcontrib>Lüscher, Christian</creatorcontrib><creatorcontrib>Krack, Paul</creatorcontrib><creatorcontrib>Burkhard, Pierre R.</creatorcontrib><title>Dyskinesia‐inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>Background
Acute dyskinesias elicited by STN‐DBS, here referred to as stimulation‐induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation‐induced dyskinesias can guide DBS programming.
Objectives
Here, we characterized stimulation‐induced dyskinesias clinically and anatomically. We then tested whether dyskinesia‐inducing contacts could be effectively programmed using independent current source technology.
Methods
We characterized stimulation‐induced dyskinesias with directional and ring stimulation retrospectively in 20 patients. We then localized dyskinesia‐inducing contacts by imaging coregistration and eventually programmed those contacts.
Results
We elicited dyskinesias in half of our patients. Dyskinesia‐inducing contacts were mainly directional and were all located ventrally within the dorsolateral motor STN. When these dyskinesia‐inducing contacts were programmed using independent current source technology, dyskinesia disappeared and robust antibradykinetic effects were obtained.
Conclusion
We confirm that stimulation‐induced dyskinesias are helpful clinical observations, which may guide programming of directional STN‐DBS in PD. © 2019 International Parkinson and Movement Disorder Society</description><subject>deep brain stimulation</subject><subject>directional</subject><subject>Dyskinesia</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson's disease</subject><subject>stimulation‐induced dyskinesia</subject><subject>subthalamic nucleus</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kM1u1DAQgK2Kii6FQ18AWeJQetjW48Rr51i19EcqAgk4W449AZfE3mYSoe2JR-AZeRJMt3BA4jSH-fRp5mPsAMQxCCFPhkDHUhtV7bAFqAqWRir9hC2EMWpZgVF77BnRrRAAClZP2V4FSoPUesG68w19jQkpup_ff8QUZh_TZ96jC9znNDk_Ec_rKQ7xHnmeJ5-HMjtOczt9cb0boudU1nPvppgTj4m_d2NRUk6HxEMkdITP2W7nesIXj3Offbp48_Hsannz7vL67PRm6WtoqnI3ihAag-iD70IdQAcEU3WNQwiw8pUyArH8qLTuat1KWau6XUHTqlo6qPbZ6613Pea7GWmyQySPfe8S5pmslE2jV6aWsqCv_kFv8zymcp2VpU8JJGpRqKMt5cdMNGJn12Mc3LixIOzv-LbEtw_xC_vy0Ti3A4a_5J_aBTjZAt9ij5v_m-zb8w9b5S_4IZAd</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Bouthour, Walid</creator><creator>Béreau, Matthieu</creator><creator>Kibleur, Astrid</creator><creator>Zacharia, André</creator><creator>Tomkova Chaoui, Emilie</creator><creator>Fleury, Vanessa</creator><creator>Benis, Damien</creator><creator>Momjian, Shahan</creator><creator>Bally, Julien</creator><creator>Lüscher, Christian</creator><creator>Krack, Paul</creator><creator>Burkhard, Pierre R.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3877-4127</orcidid><orcidid>https://orcid.org/0000-0003-0769-0289</orcidid></search><sort><creationdate>201911</creationdate><title>Dyskinesia‐inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease</title><author>Bouthour, Walid ; Béreau, Matthieu ; Kibleur, Astrid ; Zacharia, André ; Tomkova Chaoui, Emilie ; Fleury, Vanessa ; Benis, Damien ; Momjian, Shahan ; Bally, Julien ; Lüscher, Christian ; Krack, Paul ; Burkhard, Pierre R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4193-82e0dd98eecdcfd4d17de183f9ae1d16c3580ee153577f47b22454b619b542a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>deep brain stimulation</topic><topic>directional</topic><topic>Dyskinesia</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson's disease</topic><topic>stimulation‐induced dyskinesia</topic><topic>subthalamic nucleus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouthour, Walid</creatorcontrib><creatorcontrib>Béreau, Matthieu</creatorcontrib><creatorcontrib>Kibleur, Astrid</creatorcontrib><creatorcontrib>Zacharia, André</creatorcontrib><creatorcontrib>Tomkova Chaoui, Emilie</creatorcontrib><creatorcontrib>Fleury, Vanessa</creatorcontrib><creatorcontrib>Benis, Damien</creatorcontrib><creatorcontrib>Momjian, Shahan</creatorcontrib><creatorcontrib>Bally, Julien</creatorcontrib><creatorcontrib>Lüscher, Christian</creatorcontrib><creatorcontrib>Krack, Paul</creatorcontrib><creatorcontrib>Burkhard, Pierre R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouthour, Walid</au><au>Béreau, Matthieu</au><au>Kibleur, Astrid</au><au>Zacharia, André</au><au>Tomkova Chaoui, Emilie</au><au>Fleury, Vanessa</au><au>Benis, Damien</au><au>Momjian, Shahan</au><au>Bally, Julien</au><au>Lüscher, Christian</au><au>Krack, Paul</au><au>Burkhard, Pierre R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dyskinesia‐inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2019-11</date><risdate>2019</risdate><volume>34</volume><issue>11</issue><spage>1728</spage><epage>1734</epage><pages>1728-1734</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>Background
Acute dyskinesias elicited by STN‐DBS, here referred to as stimulation‐induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation‐induced dyskinesias can guide DBS programming.
Objectives
Here, we characterized stimulation‐induced dyskinesias clinically and anatomically. We then tested whether dyskinesia‐inducing contacts could be effectively programmed using independent current source technology.
Methods
We characterized stimulation‐induced dyskinesias with directional and ring stimulation retrospectively in 20 patients. We then localized dyskinesia‐inducing contacts by imaging coregistration and eventually programmed those contacts.
Results
We elicited dyskinesias in half of our patients. Dyskinesia‐inducing contacts were mainly directional and were all located ventrally within the dorsolateral motor STN. When these dyskinesia‐inducing contacts were programmed using independent current source technology, dyskinesia disappeared and robust antibradykinetic effects were obtained.
Conclusion
We confirm that stimulation‐induced dyskinesias are helpful clinical observations, which may guide programming of directional STN‐DBS in PD. © 2019 International Parkinson and Movement Disorder Society</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31571277</pmid><doi>10.1002/mds.27853</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3877-4127</orcidid><orcidid>https://orcid.org/0000-0003-0769-0289</orcidid></addata></record> |
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| subjects | deep brain stimulation directional Dyskinesia Movement disorders Neurodegenerative diseases Parkinson's disease stimulation‐induced dyskinesia subthalamic nucleus |
| title | Dyskinesia‐inducing lead contacts optimize outcome of subthalamic stimulation in Parkinson's disease |
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