The clinical characteristics of systemic lupus erythematosus patients in Indonesia: a cohort registry from an Indonesia-based tertiary referral hospital
Introduction To date, no national epidemiological data of systemic lupus erythematosus are available in Indonesia. Objective We aimed to demonstrate clinical characteristics of systemic lupus erythematosus patients of the Dr Hasan Sadikin General Hospital, one of Indonesia's top tertiary-referr...
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| Veröffentlicht in: | Lupus 2019-11, Vol.28 (13), p.1604-1609 |
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| creator | Hamijoyo, L Candrianita, S Rahmadi, A R Dewi, S Darmawan, G Suryajaya, B S Rainy, NR Hidayat, I I Moenardi, V N Wachjudi, R G |
| description | Introduction
To date, no national epidemiological data of systemic lupus erythematosus are available in Indonesia.
Objective
We aimed to demonstrate clinical characteristics of systemic lupus erythematosus patients of the Dr Hasan Sadikin General Hospital, one of Indonesia's top tertiary-referral hospitals.
Method
We reviewed retrospective cohort data from the Hasan Sadikin Lupus Registry, which was created in January 2016. Initial retrospective data were collected from the medical records of systemic lupus erythematosus patients from 2008 to 2015 and enhanced the cohort data from January 2016 to December 2017. The records were analysed for age, sex, clinical manifestations, comorbidity, treatment and outcome.
Results
Of 813 patients, 95.6% were females. Mean age at diagnosis was 27.7 ± 9.4 years, with a mean disease duration of 76.5 ± 53.1 months. Major clinical manifestations were arthritis (75.5%) and malar rash (68.3%). The majority of patients received steroid treatment, beside chloroquine and azathioprine. In total, 93 patients (11.4%) developed tuberculosis, 522 patients (64.2%) had routine follow-up and 66 patients (8.1%) died. Infection was the most common cause of death (36.4%).
Conclusion
Arthritis and malar rash were the most commonly encountered clinical manifestations in the Hasan Sadikin Lupus Registry. Tuberculosis incidence in systemic lupus erythematosus patients was high, as was the mortality rate of lupus. |
| doi_str_mv | 10.1177/0961203319878499 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2299447046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0961203319878499</sage_id><sourcerecordid>2313318349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-36481a611a5bc7a2673477f8d93b78c52acfdfad11a1a66bf43bf6961e8ebaa3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhi0EotvCnROyxIVLwI6zdsINVUArVeKy92jiTBpXSRw8zmH_CT-XWW35UCVO1nieeefjFeKNVh-0du6jaqwulTG6qV1dNc0zsdOVcwX_l8_F7pQuTvkLcUn0oJRi0r4UF0bvrVWu3omfhxGln8ISPEzSj5DAZ0yBcvAk4yDpSBnn4OW0rRtJTMc84gw5Ekcr5IBLJhkWebv0cUEK8EmC9HGMKcuE96yUjnJIcZbwD1R0QNhLbpUDMJBwwJR4hDHSGjJMr8SLASbC14_vlTh8_XK4vinuvn-7vf58V_jK6FwYW9UarNaw77yD0jrDBxjqvjGdq_2-BD_0A_QMMGa7oTLdYPkuWGMHYK7E-7PsmuKPDSm3cyCP0wQLxo3asmyaqnKqsoy-e4I-xC0tPFxbGs0m1KZqmFJnyqdIxGu1awozr9hq1Z5Ma5-axiVvH4W3bsb-T8FvlxgozgDBPf7t-l_BX-W8omI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2313318349</pqid></control><display><type>article</type><title>The clinical characteristics of systemic lupus erythematosus patients in Indonesia: a cohort registry from an Indonesia-based tertiary referral hospital</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Hamijoyo, L ; Candrianita, S ; Rahmadi, A R ; Dewi, S ; Darmawan, G ; Suryajaya, B S ; Rainy, NR ; Hidayat, I I ; Moenardi, V N ; Wachjudi, R G</creator><creatorcontrib>Hamijoyo, L ; Candrianita, S ; Rahmadi, A R ; Dewi, S ; Darmawan, G ; Suryajaya, B S ; Rainy, NR ; Hidayat, I I ; Moenardi, V N ; Wachjudi, R G</creatorcontrib><description>Introduction
To date, no national epidemiological data of systemic lupus erythematosus are available in Indonesia.
Objective
We aimed to demonstrate clinical characteristics of systemic lupus erythematosus patients of the Dr Hasan Sadikin General Hospital, one of Indonesia's top tertiary-referral hospitals.
Method
We reviewed retrospective cohort data from the Hasan Sadikin Lupus Registry, which was created in January 2016. Initial retrospective data were collected from the medical records of systemic lupus erythematosus patients from 2008 to 2015 and enhanced the cohort data from January 2016 to December 2017. The records were analysed for age, sex, clinical manifestations, comorbidity, treatment and outcome.
Results
Of 813 patients, 95.6% were females. Mean age at diagnosis was 27.7 ± 9.4 years, with a mean disease duration of 76.5 ± 53.1 months. Major clinical manifestations were arthritis (75.5%) and malar rash (68.3%). The majority of patients received steroid treatment, beside chloroquine and azathioprine. In total, 93 patients (11.4%) developed tuberculosis, 522 patients (64.2%) had routine follow-up and 66 patients (8.1%) died. Infection was the most common cause of death (36.4%).
Conclusion
Arthritis and malar rash were the most commonly encountered clinical manifestations in the Hasan Sadikin Lupus Registry. Tuberculosis incidence in systemic lupus erythematosus patients was high, as was the mortality rate of lupus.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203319878499</identifier><identifier>PMID: 31566078</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Arthritis ; Arthritis - epidemiology ; Arthritis - etiology ; Azathioprine ; Chloroquine ; Cohort Studies ; Epidemiology ; Exanthema ; Female ; Humans ; Indonesia ; Lupus ; Lupus Erythematosus, Systemic - diagnosis ; Lupus Erythematosus, Systemic - physiopathology ; Male ; Medical records ; Patients ; Registries ; Retrospective Studies ; Skin - pathology ; Systemic lupus erythematosus ; Tertiary Care Centers ; Tuberculosis ; Tuberculosis - epidemiology ; Young Adult</subject><ispartof>Lupus, 2019-11, Vol.28 (13), p.1604-1609</ispartof><rights>The Author(s) 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-36481a611a5bc7a2673477f8d93b78c52acfdfad11a1a66bf43bf6961e8ebaa3</citedby><cites>FETCH-LOGICAL-c431t-36481a611a5bc7a2673477f8d93b78c52acfdfad11a1a66bf43bf6961e8ebaa3</cites><orcidid>0000-0002-1310-674X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203319878499$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203319878499$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31566078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamijoyo, L</creatorcontrib><creatorcontrib>Candrianita, S</creatorcontrib><creatorcontrib>Rahmadi, A R</creatorcontrib><creatorcontrib>Dewi, S</creatorcontrib><creatorcontrib>Darmawan, G</creatorcontrib><creatorcontrib>Suryajaya, B S</creatorcontrib><creatorcontrib>Rainy, NR</creatorcontrib><creatorcontrib>Hidayat, I I</creatorcontrib><creatorcontrib>Moenardi, V N</creatorcontrib><creatorcontrib>Wachjudi, R G</creatorcontrib><title>The clinical characteristics of systemic lupus erythematosus patients in Indonesia: a cohort registry from an Indonesia-based tertiary referral hospital</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Introduction
To date, no national epidemiological data of systemic lupus erythematosus are available in Indonesia.
Objective
We aimed to demonstrate clinical characteristics of systemic lupus erythematosus patients of the Dr Hasan Sadikin General Hospital, one of Indonesia's top tertiary-referral hospitals.
Method
We reviewed retrospective cohort data from the Hasan Sadikin Lupus Registry, which was created in January 2016. Initial retrospective data were collected from the medical records of systemic lupus erythematosus patients from 2008 to 2015 and enhanced the cohort data from January 2016 to December 2017. The records were analysed for age, sex, clinical manifestations, comorbidity, treatment and outcome.
Results
Of 813 patients, 95.6% were females. Mean age at diagnosis was 27.7 ± 9.4 years, with a mean disease duration of 76.5 ± 53.1 months. Major clinical manifestations were arthritis (75.5%) and malar rash (68.3%). The majority of patients received steroid treatment, beside chloroquine and azathioprine. In total, 93 patients (11.4%) developed tuberculosis, 522 patients (64.2%) had routine follow-up and 66 patients (8.1%) died. Infection was the most common cause of death (36.4%).
Conclusion
Arthritis and malar rash were the most commonly encountered clinical manifestations in the Hasan Sadikin Lupus Registry. Tuberculosis incidence in systemic lupus erythematosus patients was high, as was the mortality rate of lupus.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Arthritis</subject><subject>Arthritis - epidemiology</subject><subject>Arthritis - etiology</subject><subject>Azathioprine</subject><subject>Chloroquine</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Exanthema</subject><subject>Female</subject><subject>Humans</subject><subject>Indonesia</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Lupus Erythematosus, Systemic - physiopathology</subject><subject>Male</subject><subject>Medical records</subject><subject>Patients</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Skin - pathology</subject><subject>Systemic lupus erythematosus</subject><subject>Tertiary Care Centers</subject><subject>Tuberculosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Young Adult</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EotvCnROyxIVLwI6zdsINVUArVeKy92jiTBpXSRw8zmH_CT-XWW35UCVO1nieeefjFeKNVh-0du6jaqwulTG6qV1dNc0zsdOVcwX_l8_F7pQuTvkLcUn0oJRi0r4UF0bvrVWu3omfhxGln8ISPEzSj5DAZ0yBcvAk4yDpSBnn4OW0rRtJTMc84gw5Ekcr5IBLJhkWebv0cUEK8EmC9HGMKcuE96yUjnJIcZbwD1R0QNhLbpUDMJBwwJR4hDHSGjJMr8SLASbC14_vlTh8_XK4vinuvn-7vf58V_jK6FwYW9UarNaw77yD0jrDBxjqvjGdq_2-BD_0A_QMMGa7oTLdYPkuWGMHYK7E-7PsmuKPDSm3cyCP0wQLxo3asmyaqnKqsoy-e4I-xC0tPFxbGs0m1KZqmFJnyqdIxGu1awozr9hq1Z5Ma5-axiVvH4W3bsb-T8FvlxgozgDBPf7t-l_BX-W8omI</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Hamijoyo, L</creator><creator>Candrianita, S</creator><creator>Rahmadi, A R</creator><creator>Dewi, S</creator><creator>Darmawan, G</creator><creator>Suryajaya, B S</creator><creator>Rainy, NR</creator><creator>Hidayat, I I</creator><creator>Moenardi, V N</creator><creator>Wachjudi, R G</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1310-674X</orcidid></search><sort><creationdate>20191101</creationdate><title>The clinical characteristics of systemic lupus erythematosus patients in Indonesia: a cohort registry from an Indonesia-based tertiary referral hospital</title><author>Hamijoyo, L ; Candrianita, S ; Rahmadi, A R ; Dewi, S ; Darmawan, G ; Suryajaya, B S ; Rainy, NR ; Hidayat, I I ; Moenardi, V N ; Wachjudi, R G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-36481a611a5bc7a2673477f8d93b78c52acfdfad11a1a66bf43bf6961e8ebaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Arthritis</topic><topic>Arthritis - epidemiology</topic><topic>Arthritis - etiology</topic><topic>Azathioprine</topic><topic>Chloroquine</topic><topic>Cohort Studies</topic><topic>Epidemiology</topic><topic>Exanthema</topic><topic>Female</topic><topic>Humans</topic><topic>Indonesia</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Lupus Erythematosus, Systemic - physiopathology</topic><topic>Male</topic><topic>Medical records</topic><topic>Patients</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Skin - pathology</topic><topic>Systemic lupus erythematosus</topic><topic>Tertiary Care Centers</topic><topic>Tuberculosis</topic><topic>Tuberculosis - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamijoyo, L</creatorcontrib><creatorcontrib>Candrianita, S</creatorcontrib><creatorcontrib>Rahmadi, A R</creatorcontrib><creatorcontrib>Dewi, S</creatorcontrib><creatorcontrib>Darmawan, G</creatorcontrib><creatorcontrib>Suryajaya, B S</creatorcontrib><creatorcontrib>Rainy, NR</creatorcontrib><creatorcontrib>Hidayat, I I</creatorcontrib><creatorcontrib>Moenardi, V N</creatorcontrib><creatorcontrib>Wachjudi, R G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamijoyo, L</au><au>Candrianita, S</au><au>Rahmadi, A R</au><au>Dewi, S</au><au>Darmawan, G</au><au>Suryajaya, B S</au><au>Rainy, NR</au><au>Hidayat, I I</au><au>Moenardi, V N</au><au>Wachjudi, R G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical characteristics of systemic lupus erythematosus patients in Indonesia: a cohort registry from an Indonesia-based tertiary referral hospital</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>28</volume><issue>13</issue><spage>1604</spage><epage>1609</epage><pages>1604-1609</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Introduction
To date, no national epidemiological data of systemic lupus erythematosus are available in Indonesia.
Objective
We aimed to demonstrate clinical characteristics of systemic lupus erythematosus patients of the Dr Hasan Sadikin General Hospital, one of Indonesia's top tertiary-referral hospitals.
Method
We reviewed retrospective cohort data from the Hasan Sadikin Lupus Registry, which was created in January 2016. Initial retrospective data were collected from the medical records of systemic lupus erythematosus patients from 2008 to 2015 and enhanced the cohort data from January 2016 to December 2017. The records were analysed for age, sex, clinical manifestations, comorbidity, treatment and outcome.
Results
Of 813 patients, 95.6% were females. Mean age at diagnosis was 27.7 ± 9.4 years, with a mean disease duration of 76.5 ± 53.1 months. Major clinical manifestations were arthritis (75.5%) and malar rash (68.3%). The majority of patients received steroid treatment, beside chloroquine and azathioprine. In total, 93 patients (11.4%) developed tuberculosis, 522 patients (64.2%) had routine follow-up and 66 patients (8.1%) died. Infection was the most common cause of death (36.4%).
Conclusion
Arthritis and malar rash were the most commonly encountered clinical manifestations in the Hasan Sadikin Lupus Registry. Tuberculosis incidence in systemic lupus erythematosus patients was high, as was the mortality rate of lupus.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31566078</pmid><doi>10.1177/0961203319878499</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1310-674X</orcidid></addata></record> |
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| ispartof | Lupus, 2019-11, Vol.28 (13), p.1604-1609 |
| issn | 0961-2033 1477-0962 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Adolescent Adult Arthritis Arthritis - epidemiology Arthritis - etiology Azathioprine Chloroquine Cohort Studies Epidemiology Exanthema Female Humans Indonesia Lupus Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - physiopathology Male Medical records Patients Registries Retrospective Studies Skin - pathology Systemic lupus erythematosus Tertiary Care Centers Tuberculosis Tuberculosis - epidemiology Young Adult |
| title | The clinical characteristics of systemic lupus erythematosus patients in Indonesia: a cohort registry from an Indonesia-based tertiary referral hospital |
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