Airway obstruction in young adults born extremely preterm or extremely low birth weight in the postsurfactant era
BackgroundIt is unknown if adults born
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| Veröffentlicht in: | Thorax 2019-12, Vol.74 (12), p.1147-1153 |
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| creator | Doyle, Lex William Irving, Louis Haikerwal, Anjali Lee, Katherine Ranganathan, Sarath Cheong, Jeanie |
| description | BackgroundIt is unknown if adults born |
| doi_str_mv | 10.1136/thoraxjnl-2019-213757 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2299139528</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3109444646</sourcerecordid><originalsourceid>FETCH-LOGICAL-b495t-cbf5de67acb285915ae750268df013f27d47222d214e7d199c8f2068cb3c5f363</originalsourceid><addsrcrecordid>eNqNkUtr3DAUhUVpaKZJf0KLoJtu3OjqrWUIfUGgm2YtJFnOeLCtiSQzmX8fD5NOSxehqwuX7xwOfAi9B_IZgMmruk7ZPW6moaEETEOBKaFeoRVwqRtGjXyNVoRw0kim5Dl6W8qGEKIB1Bt0zkAILalYoYfrPu_cHidfap5D7dOE-wnv0zzdY9fOQy3Ypzzh-FhzHOOwx9sca8wjTvmv55B22Pe5rvEu9vfreiip64i3qdQy586F6qaKY3aX6KxzQ4nvnu8Fuvv65dfN9-b257cfN9e3jedG1Cb4TrRRKhc81cKAcFEJQqVuOwKso6rlilLaUuBRtWBM0B0lUgfPguiYZBfo07F3m9PDHEu1Y19CHAY3xTQXS6kxwIygekE__oNu0pynZZ1lQAznXHL5EkUZcK6BCbJQ4kiFnErJsbPb3I8u7y0QezBnT-bswZw9mltyH57bZz_G9pT6rWoByBHw4-a_O-FP5DT25cwTBjq3gg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2314481350</pqid></control><display><type>article</type><title>Airway obstruction in young adults born extremely preterm or extremely low birth weight in the postsurfactant era</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Doyle, Lex William ; Irving, Louis ; Haikerwal, Anjali ; Lee, Katherine ; Ranganathan, Sarath ; Cheong, Jeanie</creator><creatorcontrib>Doyle, Lex William ; Irving, Louis ; Haikerwal, Anjali ; Lee, Katherine ; Ranganathan, Sarath ; Cheong, Jeanie</creatorcontrib><description><![CDATA[BackgroundIt is unknown if adults born <28 weeks or <1000 g since surfactant has been available are reaching their full airway growth potential.ObjectiveTo compare expiratory airflow at 25 years and from 8 to 25 years of participants born <28 weeks or <1000 g with controls, and within the preterm group to compare those who had bronchopulmonary dysplasia with those who did not.MethodsAll survivors born <28 weeks or <1000 g in 1991–1992 in Victoria, Australia, were eligible. Controls were born contemporaneously, weighing >2499 g. At 8, 18 and 25 years, expiratory airflows were measured and the results converted to z-scores. Outcomes were compared between groups at age 25 years, and trajectories (change in z-scores per year) from childhood were contrasted between groups.ResultsExpiratory airflows were measured at 25 years on 164 of 297 (55%) preterm survivors and 130 of 260 (50%) controls. Preterm participants had substantially reduced airflow compared with controls at age 25 years (eg, zFEV1; mean difference −0.97, 95% CI −1.23 to –0.71; p<0.001). Preterm participants had lower airflow trajectories than controls between 8 and 18 years, but not between 18 and 25 years. Within the preterm group, those who had bronchopulmonary dysplasia had worse airflows and trajectories than those who did not.ConclusionsYoung adults born <28 weeks or <1000 g in the surfactant era, particularly those who had bronchopulmonary dysplasia, have substantially reduced airway function compared with controls. Some are destined to develop COPD in later adult life.]]></description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thoraxjnl-2019-213757</identifier><identifier>PMID: 31558625</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Adult ; Age ; Aging - physiology ; Airway management ; Airway Obstruction - physiopathology ; Babies ; Birth weight ; Birth Weight - physiology ; Bronchopulmonary Dysplasia - physiopathology ; Bronchopulmonary Dysplasia - therapy ; Case-Control Studies ; Child development ; Chronic obstructive pulmonary disease ; Collaboration ; COPD epidemiology ; Epidemiology ; Ethnicity ; Female ; Follow-Up Studies ; Forced Expiratory Volume - physiology ; Gestational Age ; Hospitals ; Humans ; Infant, Extremely Low Birth Weight - physiology ; Infant, Extremely Premature - physiology ; Infant, Newborn ; Intensive care ; Lung diseases ; Male ; Multiple births ; Newborn babies ; Paediatric Lung Disaese ; Paediatric lung disease ; Premature Birth - physiopathology ; Pulmonary Surfactants - therapeutic use ; Pulmonary Ventilation - physiology ; Regression analysis ; Spirometry ; State government ; Steroids ; Studies ; Surfactants ; Variables ; Vital Capacity - physiology ; Young adults</subject><ispartof>Thorax, 2019-12, Vol.74 (12), p.1147-1153</ispartof><rights>Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b495t-cbf5de67acb285915ae750268df013f27d47222d214e7d199c8f2068cb3c5f363</citedby><cites>FETCH-LOGICAL-b495t-cbf5de67acb285915ae750268df013f27d47222d214e7d199c8f2068cb3c5f363</cites><orcidid>0000-0002-7667-7312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31558625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doyle, Lex William</creatorcontrib><creatorcontrib>Irving, Louis</creatorcontrib><creatorcontrib>Haikerwal, Anjali</creatorcontrib><creatorcontrib>Lee, Katherine</creatorcontrib><creatorcontrib>Ranganathan, Sarath</creatorcontrib><creatorcontrib>Cheong, Jeanie</creatorcontrib><title>Airway obstruction in young adults born extremely preterm or extremely low birth weight in the postsurfactant era</title><title>Thorax</title><addtitle>Thorax</addtitle><addtitle>Thorax</addtitle><description><![CDATA[BackgroundIt is unknown if adults born <28 weeks or <1000 g since surfactant has been available are reaching their full airway growth potential.ObjectiveTo compare expiratory airflow at 25 years and from 8 to 25 years of participants born <28 weeks or <1000 g with controls, and within the preterm group to compare those who had bronchopulmonary dysplasia with those who did not.MethodsAll survivors born <28 weeks or <1000 g in 1991–1992 in Victoria, Australia, were eligible. Controls were born contemporaneously, weighing >2499 g. At 8, 18 and 25 years, expiratory airflows were measured and the results converted to z-scores. Outcomes were compared between groups at age 25 years, and trajectories (change in z-scores per year) from childhood were contrasted between groups.ResultsExpiratory airflows were measured at 25 years on 164 of 297 (55%) preterm survivors and 130 of 260 (50%) controls. Preterm participants had substantially reduced airflow compared with controls at age 25 years (eg, zFEV1; mean difference −0.97, 95% CI −1.23 to –0.71; p<0.001). Preterm participants had lower airflow trajectories than controls between 8 and 18 years, but not between 18 and 25 years. Within the preterm group, those who had bronchopulmonary dysplasia had worse airflows and trajectories than those who did not.ConclusionsYoung adults born <28 weeks or <1000 g in the surfactant era, particularly those who had bronchopulmonary dysplasia, have substantially reduced airway function compared with controls. Some are destined to develop COPD in later adult life.]]></description><subject>Adult</subject><subject>Age</subject><subject>Aging - physiology</subject><subject>Airway management</subject><subject>Airway Obstruction - physiopathology</subject><subject>Babies</subject><subject>Birth weight</subject><subject>Birth Weight - physiology</subject><subject>Bronchopulmonary Dysplasia - physiopathology</subject><subject>Bronchopulmonary Dysplasia - therapy</subject><subject>Case-Control Studies</subject><subject>Child development</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Collaboration</subject><subject>COPD epidemiology</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Gestational Age</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant, Extremely Low Birth Weight - physiology</subject><subject>Infant, Extremely Premature - physiology</subject><subject>Infant, Newborn</subject><subject>Intensive care</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Multiple births</subject><subject>Newborn babies</subject><subject>Paediatric Lung Disaese</subject><subject>Paediatric lung disease</subject><subject>Premature Birth - physiopathology</subject><subject>Pulmonary Surfactants - therapeutic use</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Regression analysis</subject><subject>Spirometry</subject><subject>State government</subject><subject>Steroids</subject><subject>Studies</subject><subject>Surfactants</subject><subject>Variables</subject><subject>Vital Capacity - physiology</subject><subject>Young adults</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkUtr3DAUhUVpaKZJf0KLoJtu3OjqrWUIfUGgm2YtJFnOeLCtiSQzmX8fD5NOSxehqwuX7xwOfAi9B_IZgMmruk7ZPW6moaEETEOBKaFeoRVwqRtGjXyNVoRw0kim5Dl6W8qGEKIB1Bt0zkAILalYoYfrPu_cHidfap5D7dOE-wnv0zzdY9fOQy3Ypzzh-FhzHOOwx9sca8wjTvmv55B22Pe5rvEu9vfreiip64i3qdQy586F6qaKY3aX6KxzQ4nvnu8Fuvv65dfN9-b257cfN9e3jedG1Cb4TrRRKhc81cKAcFEJQqVuOwKso6rlilLaUuBRtWBM0B0lUgfPguiYZBfo07F3m9PDHEu1Y19CHAY3xTQXS6kxwIygekE__oNu0pynZZ1lQAznXHL5EkUZcK6BCbJQ4kiFnErJsbPb3I8u7y0QezBnT-bswZw9mltyH57bZz_G9pT6rWoByBHw4-a_O-FP5DT25cwTBjq3gg</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Doyle, Lex William</creator><creator>Irving, Louis</creator><creator>Haikerwal, Anjali</creator><creator>Lee, Katherine</creator><creator>Ranganathan, Sarath</creator><creator>Cheong, Jeanie</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7667-7312</orcidid></search><sort><creationdate>20191201</creationdate><title>Airway obstruction in young adults born extremely preterm or extremely low birth weight in the postsurfactant era</title><author>Doyle, Lex William ; Irving, Louis ; Haikerwal, Anjali ; Lee, Katherine ; Ranganathan, Sarath ; Cheong, Jeanie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b495t-cbf5de67acb285915ae750268df013f27d47222d214e7d199c8f2068cb3c5f363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aging - physiology</topic><topic>Airway management</topic><topic>Airway Obstruction - physiopathology</topic><topic>Babies</topic><topic>Birth weight</topic><topic>Birth Weight - physiology</topic><topic>Bronchopulmonary Dysplasia - physiopathology</topic><topic>Bronchopulmonary Dysplasia - therapy</topic><topic>Case-Control Studies</topic><topic>Child development</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Collaboration</topic><topic>COPD epidemiology</topic><topic>Epidemiology</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Gestational Age</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant, Extremely Low Birth Weight - physiology</topic><topic>Infant, Extremely Premature - physiology</topic><topic>Infant, Newborn</topic><topic>Intensive care</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Multiple births</topic><topic>Newborn babies</topic><topic>Paediatric Lung Disaese</topic><topic>Paediatric lung disease</topic><topic>Premature Birth - physiopathology</topic><topic>Pulmonary Surfactants - therapeutic use</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Regression analysis</topic><topic>Spirometry</topic><topic>State government</topic><topic>Steroids</topic><topic>Studies</topic><topic>Surfactants</topic><topic>Variables</topic><topic>Vital Capacity - physiology</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doyle, Lex William</creatorcontrib><creatorcontrib>Irving, Louis</creatorcontrib><creatorcontrib>Haikerwal, Anjali</creatorcontrib><creatorcontrib>Lee, Katherine</creatorcontrib><creatorcontrib>Ranganathan, Sarath</creatorcontrib><creatorcontrib>Cheong, Jeanie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doyle, Lex William</au><au>Irving, Louis</au><au>Haikerwal, Anjali</au><au>Lee, Katherine</au><au>Ranganathan, Sarath</au><au>Cheong, Jeanie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Airway obstruction in young adults born extremely preterm or extremely low birth weight in the postsurfactant era</atitle><jtitle>Thorax</jtitle><stitle>Thorax</stitle><addtitle>Thorax</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>74</volume><issue>12</issue><spage>1147</spage><epage>1153</epage><pages>1147-1153</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><abstract><![CDATA[BackgroundIt is unknown if adults born <28 weeks or <1000 g since surfactant has been available are reaching their full airway growth potential.ObjectiveTo compare expiratory airflow at 25 years and from 8 to 25 years of participants born <28 weeks or <1000 g with controls, and within the preterm group to compare those who had bronchopulmonary dysplasia with those who did not.MethodsAll survivors born <28 weeks or <1000 g in 1991–1992 in Victoria, Australia, were eligible. Controls were born contemporaneously, weighing >2499 g. At 8, 18 and 25 years, expiratory airflows were measured and the results converted to z-scores. Outcomes were compared between groups at age 25 years, and trajectories (change in z-scores per year) from childhood were contrasted between groups.ResultsExpiratory airflows were measured at 25 years on 164 of 297 (55%) preterm survivors and 130 of 260 (50%) controls. Preterm participants had substantially reduced airflow compared with controls at age 25 years (eg, zFEV1; mean difference −0.97, 95% CI −1.23 to –0.71; p<0.001). Preterm participants had lower airflow trajectories than controls between 8 and 18 years, but not between 18 and 25 years. Within the preterm group, those who had bronchopulmonary dysplasia had worse airflows and trajectories than those who did not.ConclusionsYoung adults born <28 weeks or <1000 g in the surfactant era, particularly those who had bronchopulmonary dysplasia, have substantially reduced airway function compared with controls. Some are destined to develop COPD in later adult life.]]></abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>31558625</pmid><doi>10.1136/thoraxjnl-2019-213757</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7667-7312</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aging - physiology Airway management Airway Obstruction - physiopathology Babies Birth weight Birth Weight - physiology Bronchopulmonary Dysplasia - physiopathology Bronchopulmonary Dysplasia - therapy Case-Control Studies Child development Chronic obstructive pulmonary disease Collaboration COPD epidemiology Epidemiology Ethnicity Female Follow-Up Studies Forced Expiratory Volume - physiology Gestational Age Hospitals Humans Infant, Extremely Low Birth Weight - physiology Infant, Extremely Premature - physiology Infant, Newborn Intensive care Lung diseases Male Multiple births Newborn babies Paediatric Lung Disaese Paediatric lung disease Premature Birth - physiopathology Pulmonary Surfactants - therapeutic use Pulmonary Ventilation - physiology Regression analysis Spirometry State government Steroids Studies Surfactants Variables Vital Capacity - physiology Young adults |
| title | Airway obstruction in young adults born extremely preterm or extremely low birth weight in the postsurfactant era |
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