Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review
Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox sta...
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| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2019-08, Vol.23 (8), p.694-699 |
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| container_title | The Journal of nutrition, health & aging |
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| creator | Martínez Leo, E. E. Segura Campos, M. R. |
| description | Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox state, as occurs in mitochondrial dysfunction, favour tissue injury and neuroinflammatory mechanisms activation. ND affect around the world about a billion people, without distinction of sex, educational level and economic status. Public measures generation that prevent ND from the SOS are possible promising therapeutic targets that could reduce the ND incidence. We discuss here the effects and mechanisms of SOS derived neurodegeneration, as well as the neuroinflammation repercussions for some cerebral structures. |
| doi_str_mv | 10.1007/s12603-019-1240-8 |
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| subjects | Aging Antioxidants Antioxidants - metabolism Free radicals Geriatrics/Gerontology Humans Inflammation Medicine Medicine & Public Health Neurodegeneration Neurodegenerative Diseases - etiology Neurodegenerative Diseases - physiopathology Neurosciences Nutrition Oxidative stress Oxidative Stress - physiology Primary Care Medicine Quality of Life Research |
| title | Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review |
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