Predicting stress resilience and vulnerability: brain-derived neurotrophic factor and rapid eye movement sleep as potential biomarkers of individual stress responses
Abstract Study Objectives To examine the rapid eye movement sleep (REM) response to mild stress as a predictor of the REM response to intense stress and brain-derived neurotrophic factor (BDNF) as a potential biomarker of stress resilience and vulnerability. Methods Outbred Wistar rats were surgical...
Gespeichert in:
Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2020-01, Vol.43 (1), p.1 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 1 |
container_start_page | 1 |
container_title | Sleep (New York, N.Y.) |
container_volume | 43 |
creator | Sweeten, Brook L W Sutton, Amy M Wellman, Laurie L Sanford, Larry D |
description | Abstract
Study Objectives
To examine the rapid eye movement sleep (REM) response to mild stress as a predictor of the REM response to intense stress and brain-derived neurotrophic factor (BDNF) as a potential biomarker of stress resilience and vulnerability.
Methods
Outbred Wistar rats were surgically implanted with electrodes for recording electroencephalography (EEG) and electromyogram (EMG) and intraperitoneal Data loggers to record body temperature. Blood was also obtained to measure circulating BDNF. After recovery, rats were exposed to mild stress (novel chamber, NC) and later intense stress (shock training, ST), followed by sleep recording. Subsequently, rats were separated into resilient (Res; n=27) or vulnerable (Vul; n = 15) based on whether or not there was a 50% or greater decrease in REM after ST compared to baseline. We then compared sleep, freezing, and the stress response (stress-induced hyperthermia, SIH) across groups to determine the effects of mild and intense stress to determine if BDNF was predictive of the REM response.
Results
REM totals in the first 4 hours of sleep after exposure to NC predicted REM responses following ST with resilient animals having higher REM and vulnerable animals having lower REM. Resilient rats had significantly higher baseline peripheral BDNF compared to vulnerable rats.
Conclusions
These results show that outbred rats display significant differences in post-stress sleep and peripheral BDNF identifying these factors as potential markers of resilience and vulnerability prior to traumatic stress. |
doi_str_mv | 10.1093/sleep/zsz199 |
format | Article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2298146294</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A617385560</galeid><oup_id>10.1093/sleep/zsz199</oup_id><sourcerecordid>A617385560</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-10863a124e10ab79cc8dd1fad817574737cc14ebade6277facd26bc9c334e1e13</originalsourceid><addsrcrecordid>eNp9kl1rFTEQhoMo9li981oCXuiF2yab_Yp3pfRDKOiFXodsMltTd5M1yR44_T_9n845p7YoIoGEmXne4WUyhLzm7IgzKY7TCDAf36ZbLuUTsuJ1zQqJladkxXjDi46z-oC8SOmGYVxJ8ZwcCKQaWbMVufsSwTqTnb-mKUdIieLlRgfeANXe0vUyeoi6x1zefKR91M4XFqJbg6UelhhyDPN3Z-igTQ5xJ4p6dpbCBugU1jCBz3Tnk-pE55AxdnqkvQuTjj8gJhoG6rx1a2cXLDw6mYNPkF6SZ4MeE7y6fw_Jt_Ozr6eXxdXni0-nJ1eFqeomF5x1jdC8rIAz3bfSmM5aPmjb8bZuq1a0xvAKem2hKdsW_dqy6Y00QqAEuDgk7_d95xh-LpCymlwyMI7aQ1iSKkvZ8aopZYXo27_Qm7BEj-5UWbEt03X1I3WtR1DODzgsbbZN1UnDW9HhPzCkjv5B4bEwORM8DA7zfwg-7AUmhpQiDGqODke5UZyp7Vao3bTVfisQf3PvdeknsA_w7zVA4N0eCMv8_1a_ALM5xdo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2404629885</pqid></control><display><type>article</type><title>Predicting stress resilience and vulnerability: brain-derived neurotrophic factor and rapid eye movement sleep as potential biomarkers of individual stress responses</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Sweeten, Brook L W ; Sutton, Amy M ; Wellman, Laurie L ; Sanford, Larry D</creator><creatorcontrib>Sweeten, Brook L W ; Sutton, Amy M ; Wellman, Laurie L ; Sanford, Larry D</creatorcontrib><description>Abstract
Study Objectives
To examine the rapid eye movement sleep (REM) response to mild stress as a predictor of the REM response to intense stress and brain-derived neurotrophic factor (BDNF) as a potential biomarker of stress resilience and vulnerability.
Methods
Outbred Wistar rats were surgically implanted with electrodes for recording electroencephalography (EEG) and electromyogram (EMG) and intraperitoneal Data loggers to record body temperature. Blood was also obtained to measure circulating BDNF. After recovery, rats were exposed to mild stress (novel chamber, NC) and later intense stress (shock training, ST), followed by sleep recording. Subsequently, rats were separated into resilient (Res; n=27) or vulnerable (Vul; n = 15) based on whether or not there was a 50% or greater decrease in REM after ST compared to baseline. We then compared sleep, freezing, and the stress response (stress-induced hyperthermia, SIH) across groups to determine the effects of mild and intense stress to determine if BDNF was predictive of the REM response.
Results
REM totals in the first 4 hours of sleep after exposure to NC predicted REM responses following ST with resilient animals having higher REM and vulnerable animals having lower REM. Resilient rats had significantly higher baseline peripheral BDNF compared to vulnerable rats.
Conclusions
These results show that outbred rats display significant differences in post-stress sleep and peripheral BDNF identifying these factors as potential markers of resilience and vulnerability prior to traumatic stress.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsz199</identifier><identifier>PMID: 31556950</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Analysis ; Biological markers ; Biomarkers ; Brain-derived neurotrophic factor ; Electrodes ; Electroencephalography ; Eye movements ; Medical research ; Novels ; Post-traumatic stress disorder ; REM sleep ; Rodents ; Shock ; Sleep ; Stress (Psychology)</subject><ispartof>Sleep (New York, N.Y.), 2020-01, Vol.43 (1), p.1</ispartof><rights>Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com. 2019</rights><rights>Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-10863a124e10ab79cc8dd1fad817574737cc14ebade6277facd26bc9c334e1e13</citedby><cites>FETCH-LOGICAL-c456t-10863a124e10ab79cc8dd1fad817574737cc14ebade6277facd26bc9c334e1e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31556950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sweeten, Brook L W</creatorcontrib><creatorcontrib>Sutton, Amy M</creatorcontrib><creatorcontrib>Wellman, Laurie L</creatorcontrib><creatorcontrib>Sanford, Larry D</creatorcontrib><title>Predicting stress resilience and vulnerability: brain-derived neurotrophic factor and rapid eye movement sleep as potential biomarkers of individual stress responses</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>Abstract
Study Objectives
To examine the rapid eye movement sleep (REM) response to mild stress as a predictor of the REM response to intense stress and brain-derived neurotrophic factor (BDNF) as a potential biomarker of stress resilience and vulnerability.
Methods
Outbred Wistar rats were surgically implanted with electrodes for recording electroencephalography (EEG) and electromyogram (EMG) and intraperitoneal Data loggers to record body temperature. Blood was also obtained to measure circulating BDNF. After recovery, rats were exposed to mild stress (novel chamber, NC) and later intense stress (shock training, ST), followed by sleep recording. Subsequently, rats were separated into resilient (Res; n=27) or vulnerable (Vul; n = 15) based on whether or not there was a 50% or greater decrease in REM after ST compared to baseline. We then compared sleep, freezing, and the stress response (stress-induced hyperthermia, SIH) across groups to determine the effects of mild and intense stress to determine if BDNF was predictive of the REM response.
Results
REM totals in the first 4 hours of sleep after exposure to NC predicted REM responses following ST with resilient animals having higher REM and vulnerable animals having lower REM. Resilient rats had significantly higher baseline peripheral BDNF compared to vulnerable rats.
Conclusions
These results show that outbred rats display significant differences in post-stress sleep and peripheral BDNF identifying these factors as potential markers of resilience and vulnerability prior to traumatic stress.</description><subject>Analysis</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Brain-derived neurotrophic factor</subject><subject>Electrodes</subject><subject>Electroencephalography</subject><subject>Eye movements</subject><subject>Medical research</subject><subject>Novels</subject><subject>Post-traumatic stress disorder</subject><subject>REM sleep</subject><subject>Rodents</subject><subject>Shock</subject><subject>Sleep</subject><subject>Stress (Psychology)</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kl1rFTEQhoMo9li981oCXuiF2yab_Yp3pfRDKOiFXodsMltTd5M1yR44_T_9n845p7YoIoGEmXne4WUyhLzm7IgzKY7TCDAf36ZbLuUTsuJ1zQqJladkxXjDi46z-oC8SOmGYVxJ8ZwcCKQaWbMVufsSwTqTnb-mKUdIieLlRgfeANXe0vUyeoi6x1zefKR91M4XFqJbg6UelhhyDPN3Z-igTQ5xJ4p6dpbCBugU1jCBz3Tnk-pE55AxdnqkvQuTjj8gJhoG6rx1a2cXLDw6mYNPkF6SZ4MeE7y6fw_Jt_Ozr6eXxdXni0-nJ1eFqeomF5x1jdC8rIAz3bfSmM5aPmjb8bZuq1a0xvAKem2hKdsW_dqy6Y00QqAEuDgk7_d95xh-LpCymlwyMI7aQ1iSKkvZ8aopZYXo27_Qm7BEj-5UWbEt03X1I3WtR1DODzgsbbZN1UnDW9HhPzCkjv5B4bEwORM8DA7zfwg-7AUmhpQiDGqODke5UZyp7Vao3bTVfisQf3PvdeknsA_w7zVA4N0eCMv8_1a_ALM5xdo</recordid><startdate>20200113</startdate><enddate>20200113</enddate><creator>Sweeten, Brook L W</creator><creator>Sutton, Amy M</creator><creator>Wellman, Laurie L</creator><creator>Sanford, Larry D</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20200113</creationdate><title>Predicting stress resilience and vulnerability: brain-derived neurotrophic factor and rapid eye movement sleep as potential biomarkers of individual stress responses</title><author>Sweeten, Brook L W ; Sutton, Amy M ; Wellman, Laurie L ; Sanford, Larry D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-10863a124e10ab79cc8dd1fad817574737cc14ebade6277facd26bc9c334e1e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Brain-derived neurotrophic factor</topic><topic>Electrodes</topic><topic>Electroencephalography</topic><topic>Eye movements</topic><topic>Medical research</topic><topic>Novels</topic><topic>Post-traumatic stress disorder</topic><topic>REM sleep</topic><topic>Rodents</topic><topic>Shock</topic><topic>Sleep</topic><topic>Stress (Psychology)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sweeten, Brook L W</creatorcontrib><creatorcontrib>Sutton, Amy M</creatorcontrib><creatorcontrib>Wellman, Laurie L</creatorcontrib><creatorcontrib>Sanford, Larry D</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sweeten, Brook L W</au><au>Sutton, Amy M</au><au>Wellman, Laurie L</au><au>Sanford, Larry D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting stress resilience and vulnerability: brain-derived neurotrophic factor and rapid eye movement sleep as potential biomarkers of individual stress responses</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2020-01-13</date><risdate>2020</risdate><volume>43</volume><issue>1</issue><spage>1</spage><pages>1-</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Study Objectives
To examine the rapid eye movement sleep (REM) response to mild stress as a predictor of the REM response to intense stress and brain-derived neurotrophic factor (BDNF) as a potential biomarker of stress resilience and vulnerability.
Methods
Outbred Wistar rats were surgically implanted with electrodes for recording electroencephalography (EEG) and electromyogram (EMG) and intraperitoneal Data loggers to record body temperature. Blood was also obtained to measure circulating BDNF. After recovery, rats were exposed to mild stress (novel chamber, NC) and later intense stress (shock training, ST), followed by sleep recording. Subsequently, rats were separated into resilient (Res; n=27) or vulnerable (Vul; n = 15) based on whether or not there was a 50% or greater decrease in REM after ST compared to baseline. We then compared sleep, freezing, and the stress response (stress-induced hyperthermia, SIH) across groups to determine the effects of mild and intense stress to determine if BDNF was predictive of the REM response.
Results
REM totals in the first 4 hours of sleep after exposure to NC predicted REM responses following ST with resilient animals having higher REM and vulnerable animals having lower REM. Resilient rats had significantly higher baseline peripheral BDNF compared to vulnerable rats.
Conclusions
These results show that outbred rats display significant differences in post-stress sleep and peripheral BDNF identifying these factors as potential markers of resilience and vulnerability prior to traumatic stress.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31556950</pmid><doi>10.1093/sleep/zsz199</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0161-8105 |
ispartof | Sleep (New York, N.Y.), 2020-01, Vol.43 (1), p.1 |
issn | 0161-8105 1550-9109 |
language | eng |
recordid | cdi_proquest_miscellaneous_2298146294 |
source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
subjects | Analysis Biological markers Biomarkers Brain-derived neurotrophic factor Electrodes Electroencephalography Eye movements Medical research Novels Post-traumatic stress disorder REM sleep Rodents Shock Sleep Stress (Psychology) |
title | Predicting stress resilience and vulnerability: brain-derived neurotrophic factor and rapid eye movement sleep as potential biomarkers of individual stress responses |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T18%3A37%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Predicting%20stress%20resilience%20and%20vulnerability:%20brain-derived%20neurotrophic%20factor%20and%20rapid%20eye%20movement%20sleep%20as%20potential%20biomarkers%20of%20individual%20stress%20responses&rft.jtitle=Sleep%20(New%20York,%20N.Y.)&rft.au=Sweeten,%20Brook%20L%20W&rft.date=2020-01-13&rft.volume=43&rft.issue=1&rft.spage=1&rft.pages=1-&rft.issn=0161-8105&rft.eissn=1550-9109&rft_id=info:doi/10.1093/sleep/zsz199&rft_dat=%3Cgale_proqu%3EA617385560%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2404629885&rft_id=info:pmid/31556950&rft_galeid=A617385560&rft_oup_id=10.1093/sleep/zsz199&rfr_iscdi=true |