Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus

Ribonucleases H (RNases H) are endonucleolytic enzymes, evolutionarily related to retroviral integrases, DNA transposases, resolvases and numerous nucleases. RNases H cleave RNA in RNA/DNA hybrids and their activity plays an important role in the replication of prokaryotic and eukaryotic genomes, as...

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Veröffentlicht in:	Antiviral research 2019-11, Vol.171, p.104613-104613, Article 104613
Hauptverfasser:	Tramontano, Enzo, Corona, Angela, Menéndez-Arias, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Hepatitis B virus HIV Reverse transcriptase Ribonuclease H
Online-Zugang:	Volltext
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