Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies
Aim To compare the systemic cytokines/chemokines levels over time during the evolution of children hospitalized with community‐acquired pneumonia (CAP) with and without pneumococcal infection. Methods Children less than 5‐years‐old hospitalized with CAP were prospectively investigated in Salvador, B...
Gespeichert in:
| Veröffentlicht in: | Pediatric pulmonology 2020-01, Vol.55 (1), p.169-176 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 176 |
|---|---|
| container_issue | 1 |
| container_start_page | 169 |
| container_title | Pediatric pulmonology |
| container_volume | 55 |
| creator | Nascimento‐Carvalho, Eduardo C. Vasconcellos, Ângela G. Clarêncio, Jorge Andrade, Daniela Barral, Aldina Barral‐Netto, Manoel Nascimento‐Carvalho, Cristiana M. |
| description | Aim
To compare the systemic cytokines/chemokines levels over time during the evolution of children hospitalized with community‐acquired pneumonia (CAP) with and without pneumococcal infection.
Methods
Children less than 5‐years‐old hospitalized with CAP were prospectively investigated in Salvador, Brazil. Clinical data and biological samples were collected to investigate 20 etiological agents and to determine serum cytokines/chemokines levels on admission and 2 to 4 weeks later. Cases with pneumococcal infection received this diagnosis irrespective of also having other etiologies.
Results
A total of 277 patients were enrolled, however, serum sample was unavailable for cytokine measurement upon admission (n = 61) or upon follow‐up visit (n = 36), etiology was undetected (n = 50) and one patient did not attend the follow‐up visit. Therefore, this study group comprised of 129 cases with established etiology. The median (interquartile range) age and sampling interval was 18 (9‐27) months and 18 (16‐21) days, respectively. Established etiology was viral (52.0%), viral‐bacterial (30.2%), and bacterial (17.8%). Pneumococcal infection was found in 31 (24.0%) patients. Overall, median interleukin‐6 (IL‐6; 10.6 [4.7‐30.6] vs 21.0 [20.2‐21.7]; P = .03), IL‐10 (3.5 [3.1‐4.5] vs 20.1 [19.8‐20.4]; P |
| doi_str_mv | 10.1002/ppul.24533 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2297128123</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2297128123</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3933-9229a503238bc5e7da9758ec6739eb1c4a9a7455da7627449c546862cedb2a13</originalsourceid><addsrcrecordid>eNp9kM1O3DAURi1UVKbQTR8AWeqmqpTBP3EcL9FoSiuNBAtYWx7nDmOa2CGOGc2uj9Bn5ElqGmDBgtX9pHt0dO-H0BdK5pQQdtb3qZ2zUnB-gGaUKFWQUlUf0KyWQhRVXfEj9CnGO0LyTtGP6IhTIbhgcoY2y4fQptEFj8MG2_0YfjsP8cxuoZsidh5bE3PYuXGLbei65N24f_zz19j75AZocO8hdcE7g41vcOPi6LwdMWRvG24dxBN0uDFthM_P8xhd_1heL34Wq8uLX4vzVWG54rxQjCkjCGe8XlsBsjFKihpsJbmCNbWlUUaWQjRGVkyWpbKizP8xC82aGcqP0bdJ2w_hPkEcdeeihbY1HkKKOuslZTVlPKNf36B3IQ0-H6cZZ3VVVqJSmfo-UXYIMQ6w0f3gOjPsNSX6qXz9VL7-X36GT5-Vad1B84q-tJ0BOgE718L-HZW-urpZTdJ_tFORXg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2328646569</pqid></control><display><type>article</type><title>Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies</title><source>Wiley Online Library All Journals</source><creator>Nascimento‐Carvalho, Eduardo C. ; Vasconcellos, Ângela G. ; Clarêncio, Jorge ; Andrade, Daniela ; Barral, Aldina ; Barral‐Netto, Manoel ; Nascimento‐Carvalho, Cristiana M.</creator><creatorcontrib>Nascimento‐Carvalho, Eduardo C. ; Vasconcellos, Ângela G. ; Clarêncio, Jorge ; Andrade, Daniela ; Barral, Aldina ; Barral‐Netto, Manoel ; Nascimento‐Carvalho, Cristiana M.</creatorcontrib><description>Aim
To compare the systemic cytokines/chemokines levels over time during the evolution of children hospitalized with community‐acquired pneumonia (CAP) with and without pneumococcal infection.
Methods
Children less than 5‐years‐old hospitalized with CAP were prospectively investigated in Salvador, Brazil. Clinical data and biological samples were collected to investigate 20 etiological agents and to determine serum cytokines/chemokines levels on admission and 2 to 4 weeks later. Cases with pneumococcal infection received this diagnosis irrespective of also having other etiologies.
Results
A total of 277 patients were enrolled, however, serum sample was unavailable for cytokine measurement upon admission (n = 61) or upon follow‐up visit (n = 36), etiology was undetected (n = 50) and one patient did not attend the follow‐up visit. Therefore, this study group comprised of 129 cases with established etiology. The median (interquartile range) age and sampling interval was 18 (9‐27) months and 18 (16‐21) days, respectively. Established etiology was viral (52.0%), viral‐bacterial (30.2%), and bacterial (17.8%). Pneumococcal infection was found in 31 (24.0%) patients. Overall, median interleukin‐6 (IL‐6; 10.6 [4.7‐30.6] vs 21.0 [20.2‐21.7]; P = .03), IL‐10 (3.5 [3.1‐4.5] vs 20.1 [19.8‐20.4]; P < .001), and CCL2 (19.3 [12.4‐23.2] vs 94.0 [67.2‐117.8]; P < .001) were significantly higher in convalescent serum samples, whereas median CXCL10 (83.6 [36.4‐182.9] vs 14.6 [0‐116.6]; P < .001) was lower. Acute vs convalescent levels evolution of IL‐10, CCL2, and CXCL10 did not differ among patients with or without pneumococcal infection. However, IL‐6 decreased (27.8 [12.3‐48.6] vs 20.8 [20.2‐22.6]; P = .1) in patients with pneumococcal infection and increased (9.0 [4.2‐22.6] vs 21.0 [20.2‐21.7]; P = .001) in patients without it.
Conclusion
The marked increase of IL‐6 serum levels during the acute phase makes it a potential biomarker of pneumococcal infection among children with CAP.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.24533</identifier><identifier>PMID: 31553527</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>acute respiratory infection ; Chemokines ; child ; Cytokines ; Etiology ; Evolution ; Infections ; lower respiratory tract infection ; lung disease ; pneumococcal infection ; Pneumonia</subject><ispartof>Pediatric pulmonology, 2020-01, Vol.55 (1), p.169-176</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3933-9229a503238bc5e7da9758ec6739eb1c4a9a7455da7627449c546862cedb2a13</citedby><cites>FETCH-LOGICAL-c3933-9229a503238bc5e7da9758ec6739eb1c4a9a7455da7627449c546862cedb2a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.24533$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.24533$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31553527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nascimento‐Carvalho, Eduardo C.</creatorcontrib><creatorcontrib>Vasconcellos, Ângela G.</creatorcontrib><creatorcontrib>Clarêncio, Jorge</creatorcontrib><creatorcontrib>Andrade, Daniela</creatorcontrib><creatorcontrib>Barral, Aldina</creatorcontrib><creatorcontrib>Barral‐Netto, Manoel</creatorcontrib><creatorcontrib>Nascimento‐Carvalho, Cristiana M.</creatorcontrib><title>Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Aim
To compare the systemic cytokines/chemokines levels over time during the evolution of children hospitalized with community‐acquired pneumonia (CAP) with and without pneumococcal infection.
Methods
Children less than 5‐years‐old hospitalized with CAP were prospectively investigated in Salvador, Brazil. Clinical data and biological samples were collected to investigate 20 etiological agents and to determine serum cytokines/chemokines levels on admission and 2 to 4 weeks later. Cases with pneumococcal infection received this diagnosis irrespective of also having other etiologies.
Results
A total of 277 patients were enrolled, however, serum sample was unavailable for cytokine measurement upon admission (n = 61) or upon follow‐up visit (n = 36), etiology was undetected (n = 50) and one patient did not attend the follow‐up visit. Therefore, this study group comprised of 129 cases with established etiology. The median (interquartile range) age and sampling interval was 18 (9‐27) months and 18 (16‐21) days, respectively. Established etiology was viral (52.0%), viral‐bacterial (30.2%), and bacterial (17.8%). Pneumococcal infection was found in 31 (24.0%) patients. Overall, median interleukin‐6 (IL‐6; 10.6 [4.7‐30.6] vs 21.0 [20.2‐21.7]; P = .03), IL‐10 (3.5 [3.1‐4.5] vs 20.1 [19.8‐20.4]; P < .001), and CCL2 (19.3 [12.4‐23.2] vs 94.0 [67.2‐117.8]; P < .001) were significantly higher in convalescent serum samples, whereas median CXCL10 (83.6 [36.4‐182.9] vs 14.6 [0‐116.6]; P < .001) was lower. Acute vs convalescent levels evolution of IL‐10, CCL2, and CXCL10 did not differ among patients with or without pneumococcal infection. However, IL‐6 decreased (27.8 [12.3‐48.6] vs 20.8 [20.2‐22.6]; P = .1) in patients with pneumococcal infection and increased (9.0 [4.2‐22.6] vs 21.0 [20.2‐21.7]; P = .001) in patients without it.
Conclusion
The marked increase of IL‐6 serum levels during the acute phase makes it a potential biomarker of pneumococcal infection among children with CAP.</description><subject>acute respiratory infection</subject><subject>Chemokines</subject><subject>child</subject><subject>Cytokines</subject><subject>Etiology</subject><subject>Evolution</subject><subject>Infections</subject><subject>lower respiratory tract infection</subject><subject>lung disease</subject><subject>pneumococcal infection</subject><subject>Pneumonia</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kM1O3DAURi1UVKbQTR8AWeqmqpTBP3EcL9FoSiuNBAtYWx7nDmOa2CGOGc2uj9Bn5ElqGmDBgtX9pHt0dO-H0BdK5pQQdtb3qZ2zUnB-gGaUKFWQUlUf0KyWQhRVXfEj9CnGO0LyTtGP6IhTIbhgcoY2y4fQptEFj8MG2_0YfjsP8cxuoZsidh5bE3PYuXGLbei65N24f_zz19j75AZocO8hdcE7g41vcOPi6LwdMWRvG24dxBN0uDFthM_P8xhd_1heL34Wq8uLX4vzVWG54rxQjCkjCGe8XlsBsjFKihpsJbmCNbWlUUaWQjRGVkyWpbKizP8xC82aGcqP0bdJ2w_hPkEcdeeihbY1HkKKOuslZTVlPKNf36B3IQ0-H6cZZ3VVVqJSmfo-UXYIMQ6w0f3gOjPsNSX6qXz9VL7-X36GT5-Vad1B84q-tJ0BOgE718L-HZW-urpZTdJ_tFORXg</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Nascimento‐Carvalho, Eduardo C.</creator><creator>Vasconcellos, Ângela G.</creator><creator>Clarêncio, Jorge</creator><creator>Andrade, Daniela</creator><creator>Barral, Aldina</creator><creator>Barral‐Netto, Manoel</creator><creator>Nascimento‐Carvalho, Cristiana M.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202001</creationdate><title>Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies</title><author>Nascimento‐Carvalho, Eduardo C. ; Vasconcellos, Ângela G. ; Clarêncio, Jorge ; Andrade, Daniela ; Barral, Aldina ; Barral‐Netto, Manoel ; Nascimento‐Carvalho, Cristiana M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3933-9229a503238bc5e7da9758ec6739eb1c4a9a7455da7627449c546862cedb2a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>acute respiratory infection</topic><topic>Chemokines</topic><topic>child</topic><topic>Cytokines</topic><topic>Etiology</topic><topic>Evolution</topic><topic>Infections</topic><topic>lower respiratory tract infection</topic><topic>lung disease</topic><topic>pneumococcal infection</topic><topic>Pneumonia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nascimento‐Carvalho, Eduardo C.</creatorcontrib><creatorcontrib>Vasconcellos, Ângela G.</creatorcontrib><creatorcontrib>Clarêncio, Jorge</creatorcontrib><creatorcontrib>Andrade, Daniela</creatorcontrib><creatorcontrib>Barral, Aldina</creatorcontrib><creatorcontrib>Barral‐Netto, Manoel</creatorcontrib><creatorcontrib>Nascimento‐Carvalho, Cristiana M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nascimento‐Carvalho, Eduardo C.</au><au>Vasconcellos, Ângela G.</au><au>Clarêncio, Jorge</au><au>Andrade, Daniela</au><au>Barral, Aldina</au><au>Barral‐Netto, Manoel</au><au>Nascimento‐Carvalho, Cristiana M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2020-01</date><risdate>2020</risdate><volume>55</volume><issue>1</issue><spage>169</spage><epage>176</epage><pages>169-176</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Aim
To compare the systemic cytokines/chemokines levels over time during the evolution of children hospitalized with community‐acquired pneumonia (CAP) with and without pneumococcal infection.
Methods
Children less than 5‐years‐old hospitalized with CAP were prospectively investigated in Salvador, Brazil. Clinical data and biological samples were collected to investigate 20 etiological agents and to determine serum cytokines/chemokines levels on admission and 2 to 4 weeks later. Cases with pneumococcal infection received this diagnosis irrespective of also having other etiologies.
Results
A total of 277 patients were enrolled, however, serum sample was unavailable for cytokine measurement upon admission (n = 61) or upon follow‐up visit (n = 36), etiology was undetected (n = 50) and one patient did not attend the follow‐up visit. Therefore, this study group comprised of 129 cases with established etiology. The median (interquartile range) age and sampling interval was 18 (9‐27) months and 18 (16‐21) days, respectively. Established etiology was viral (52.0%), viral‐bacterial (30.2%), and bacterial (17.8%). Pneumococcal infection was found in 31 (24.0%) patients. Overall, median interleukin‐6 (IL‐6; 10.6 [4.7‐30.6] vs 21.0 [20.2‐21.7]; P = .03), IL‐10 (3.5 [3.1‐4.5] vs 20.1 [19.8‐20.4]; P < .001), and CCL2 (19.3 [12.4‐23.2] vs 94.0 [67.2‐117.8]; P < .001) were significantly higher in convalescent serum samples, whereas median CXCL10 (83.6 [36.4‐182.9] vs 14.6 [0‐116.6]; P < .001) was lower. Acute vs convalescent levels evolution of IL‐10, CCL2, and CXCL10 did not differ among patients with or without pneumococcal infection. However, IL‐6 decreased (27.8 [12.3‐48.6] vs 20.8 [20.2‐22.6]; P = .1) in patients with pneumococcal infection and increased (9.0 [4.2‐22.6] vs 21.0 [20.2‐21.7]; P = .001) in patients without it.
Conclusion
The marked increase of IL‐6 serum levels during the acute phase makes it a potential biomarker of pneumococcal infection among children with CAP.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31553527</pmid><doi>10.1002/ppul.24533</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8755-6863 |
| ispartof | Pediatric pulmonology, 2020-01, Vol.55 (1), p.169-176 |
| issn | 8755-6863 1099-0496 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2297128123 |
| source | Wiley Online Library All Journals |
| subjects | acute respiratory infection Chemokines child Cytokines Etiology Evolution Infections lower respiratory tract infection lung disease pneumococcal infection Pneumonia |
| title | Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T12%3A41%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evolution%20of%20cytokines/chemokines%20in%20cases%20with%20community%E2%80%90acquired%20pneumonia%20and%20distinct%20etiologies&rft.jtitle=Pediatric%20pulmonology&rft.au=Nascimento%E2%80%90Carvalho,%20Eduardo%20C.&rft.date=2020-01&rft.volume=55&rft.issue=1&rft.spage=169&rft.epage=176&rft.pages=169-176&rft.issn=8755-6863&rft.eissn=1099-0496&rft_id=info:doi/10.1002/ppul.24533&rft_dat=%3Cproquest_cross%3E2297128123%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2328646569&rft_id=info:pmid/31553527&rfr_iscdi=true |