Comparison of BEAMing and Droplet Digital PCR for Circulating Tumor DNA Analysis

Circulating tumor DNA (ctDNA) assays are increasingly used for clinical decision-making, but it is unknown how well different assays agree. We aimed to assess the agreement in ctDNA mutation calling between BEAMing (beads, emulsion, amplification, and magnetics) and droplet digital PCR (ddPCR), 2 of...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2019-11, Vol.65 (11), p.1405-1413
Hauptverfasser:	O'Leary, Ben, Hrebien, Sarah, Beaney, Matthew, Fribbens, Charlotte, Garcia-Murillas, Isaac, Jiang, John, Li, Yuan, Huang Bartlett, Cynthia, André, Fabrice, Loibl, Sibylle, Loi, Sherene, Cristofanilli, Massimo, Turner, Nicholas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Agreements Beads Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - blood Breast Neoplasms - genetics Circulating Tumor DNA - blood Circulating Tumor DNA - genetics Class I Phosphatidylinositol 3-Kinases - blood Class I Phosphatidylinositol 3-Kinases - genetics Clinical decision making Decision making Deoxyribonucleic acid DNA Droplets Endocrine therapy ESR1 protein Estrogen Receptor alpha - blood Estrogen Receptor alpha - genetics Female Gene frequency Humans Lung cancer Metastasis Mutation Patients Plasma Polymerase chain reaction Polymerase Chain Reaction - methods Reproducibility of Results Sampling Sampling methods Stochasticity Tumors
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