Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: Preliminary findings from a follow-up resting state fMRI study
•Changes in FPN may provide common and distinct markers to affective disorders.•Changes in right-side frontal cortex may distinguish BD from MDD and HC.•Changes in parietal cortex may be the commonality of affective disorders.•Patient groups showed different neural patterns in the frontal and pariet...
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| Veröffentlicht in: | Journal of affective disorders 2020-01, Vol.260, p.653-659 |
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| container_title | Journal of affective disorders |
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| creator | Jiang, Xiaowei Fu, Shinan Yin, Zhiyang Kang, Jiahui Wang, Xinrui Zhou, Yifang Wei, Shengnan Wu, Feng Kong, Lingtao Wang, Fei Tang, Yanqing |
| description | •Changes in FPN may provide common and distinct markers to affective disorders.•Changes in right-side frontal cortex may distinguish BD from MDD and HC.•Changes in parietal cortex may be the commonality of affective disorders.•Patient groups showed different neural patterns in the frontal and parietal cortex.•ReHo is a sensitive method to detect neuroactivities in FE-affective disorders.
It is difficult to distinguish bipolar disorder (BD) from major depressive disorder (MDD), especially with the initial depressive episode. In this study, we compared neural activities of BD and MDD patients during the first-episode (FE) to investigate common and distinct neural activities and further explore predictive indicators in the two diseases.
FE-MDD patients were performed resting state functional magnetic resonance imaging and followed up after scanning. After follow-up, FE-MDD patients were regrouped into FE-BD and FE-MDD patients. The study included 24 FE-BD patients, 28 FE-MDD patients, and 30 age- and sex-matched healthy controls (HC) to investigate neural activities with regional homogeneity (ReHo) analysis among the 3 groups.
Compared to HC, FE-BD patients displayed significantly higher ReHo values in the superior frontal gyrus, the medial superior frontal gyrus within right-side cerebral hemisphere than FE-MDD patients and HC. Compared to HC, FE-BD and FE-MDD patients displayed significant decreased ReHo values in the paracentral lobule, the precuneus and the median cingulate and paracingulate gyrus within bilateral cerebral hemisphere, and the postcentral gyrus and the precentral gyrus within the right-side. FE-BD displayed significant lower ReHo values than FE-MDD patients in these regions.
The potential effects of medicine, age, course of disease and handedness on results could not be ignored.
Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of affective disorders. |
| doi_str_mv | 10.1016/j.jad.2019.09.063 |
| format | Article |
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It is difficult to distinguish bipolar disorder (BD) from major depressive disorder (MDD), especially with the initial depressive episode. In this study, we compared neural activities of BD and MDD patients during the first-episode (FE) to investigate common and distinct neural activities and further explore predictive indicators in the two diseases.
FE-MDD patients were performed resting state functional magnetic resonance imaging and followed up after scanning. After follow-up, FE-MDD patients were regrouped into FE-BD and FE-MDD patients. The study included 24 FE-BD patients, 28 FE-MDD patients, and 30 age- and sex-matched healthy controls (HC) to investigate neural activities with regional homogeneity (ReHo) analysis among the 3 groups.
Compared to HC, FE-BD patients displayed significantly higher ReHo values in the superior frontal gyrus, the medial superior frontal gyrus within right-side cerebral hemisphere than FE-MDD patients and HC. Compared to HC, FE-BD and FE-MDD patients displayed significant decreased ReHo values in the paracentral lobule, the precuneus and the median cingulate and paracingulate gyrus within bilateral cerebral hemisphere, and the postcentral gyrus and the precentral gyrus within the right-side. FE-BD displayed significant lower ReHo values than FE-MDD patients in these regions.
The potential effects of medicine, age, course of disease and handedness on results could not be ignored.
Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of affective disorders.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2019.09.063</identifier><identifier>PMID: 31542559</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Bipolar disorder ; Bipolar Disorder - physiopathology ; Brain - physiopathology ; Depressive Disorder, Major - physiopathology ; Female ; Follow-up ; Follow-Up Studies ; Frontal Lobe - physiopathology ; Humans ; Magnetic Resonance Imaging ; Major depressive disorder ; Male ; Middle Aged ; Parietal Lobe - physiopathology ; Prefrontal Cortex - physiopathology ; Regional homogeneity ; Resting-state fMRI</subject><ispartof>Journal of affective disorders, 2020-01, Vol.260, p.653-659</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1a0c4a4549e1c0cf47a5a13d754e7f63b958a1fcf4ab6a5c811dcfb6f3fa31f03</citedby><cites>FETCH-LOGICAL-c353t-1a0c4a4549e1c0cf47a5a13d754e7f63b958a1fcf4ab6a5c811dcfb6f3fa31f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165032719314570$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31542559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Xiaowei</creatorcontrib><creatorcontrib>Fu, Shinan</creatorcontrib><creatorcontrib>Yin, Zhiyang</creatorcontrib><creatorcontrib>Kang, Jiahui</creatorcontrib><creatorcontrib>Wang, Xinrui</creatorcontrib><creatorcontrib>Zhou, Yifang</creatorcontrib><creatorcontrib>Wei, Shengnan</creatorcontrib><creatorcontrib>Wu, Feng</creatorcontrib><creatorcontrib>Kong, Lingtao</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Tang, Yanqing</creatorcontrib><title>Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: Preliminary findings from a follow-up resting state fMRI study</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>•Changes in FPN may provide common and distinct markers to affective disorders.•Changes in right-side frontal cortex may distinguish BD from MDD and HC.•Changes in parietal cortex may be the commonality of affective disorders.•Patient groups showed different neural patterns in the frontal and parietal cortex.•ReHo is a sensitive method to detect neuroactivities in FE-affective disorders.
It is difficult to distinguish bipolar disorder (BD) from major depressive disorder (MDD), especially with the initial depressive episode. In this study, we compared neural activities of BD and MDD patients during the first-episode (FE) to investigate common and distinct neural activities and further explore predictive indicators in the two diseases.
FE-MDD patients were performed resting state functional magnetic resonance imaging and followed up after scanning. After follow-up, FE-MDD patients were regrouped into FE-BD and FE-MDD patients. The study included 24 FE-BD patients, 28 FE-MDD patients, and 30 age- and sex-matched healthy controls (HC) to investigate neural activities with regional homogeneity (ReHo) analysis among the 3 groups.
Compared to HC, FE-BD patients displayed significantly higher ReHo values in the superior frontal gyrus, the medial superior frontal gyrus within right-side cerebral hemisphere than FE-MDD patients and HC. Compared to HC, FE-BD and FE-MDD patients displayed significant decreased ReHo values in the paracentral lobule, the precuneus and the median cingulate and paracingulate gyrus within bilateral cerebral hemisphere, and the postcentral gyrus and the precentral gyrus within the right-side. FE-BD displayed significant lower ReHo values than FE-MDD patients in these regions.
The potential effects of medicine, age, course of disease and handedness on results could not be ignored.
Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of affective disorders.</description><subject>Adult</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Brain - physiopathology</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Female</subject><subject>Follow-up</subject><subject>Follow-Up Studies</subject><subject>Frontal Lobe - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parietal Lobe - physiopathology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Regional homogeneity</subject><subject>Resting-state fMRI</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EopfCA7BBXrLJxY7jpIEVuuKnUhEIwdqa2OPKIbGD7dyqT8er4fSWLpFGsuVz5vOMDiEvOdtzxts3434Es68Z7_esVCsekR2XnahqybvHZFc8smKi7s7Is5RGxljbd-wpORNcNrWU_Y78OYR5Dp6CN9S4lJ3XmXpcI0wUdHZHlx0m6jy1MfgcFogOcxE95psQf90pLqZc4eJSMEgHt4QJ4kYL0WC8Q88whvKES8SU3BEf1Lf0W8TJzc5DvC0kb5y_TttnMwVqwzSFm2pdaOkrs13TlCEjtV--X5bram6fkycWpoQv7s9z8vPjhx-Hz9XV10-Xh_dXlRZS5IoD0w00sumRa6Zt04EELkwnG-xsK4ZeXgC3RYChBakvODfaDq0VFgS3TJyT1yfuEsPvtQyjZpc0ThN4DGtSdd23XHR1L4qVn6w6hpQiWrVEN5f1FGdqy02NquSmttwUK9VuPa_u8eswo3no-BdUMbw7GbAseXQYVdIOvUbjIuqsTHD_wf8FU8au2w</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Jiang, Xiaowei</creator><creator>Fu, Shinan</creator><creator>Yin, Zhiyang</creator><creator>Kang, Jiahui</creator><creator>Wang, Xinrui</creator><creator>Zhou, Yifang</creator><creator>Wei, Shengnan</creator><creator>Wu, Feng</creator><creator>Kong, Lingtao</creator><creator>Wang, Fei</creator><creator>Tang, Yanqing</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200101</creationdate><title>Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: Preliminary findings from a follow-up resting state fMRI study</title><author>Jiang, Xiaowei ; Fu, Shinan ; Yin, Zhiyang ; Kang, Jiahui ; Wang, Xinrui ; Zhou, Yifang ; Wei, Shengnan ; Wu, Feng ; Kong, Lingtao ; Wang, Fei ; Tang, Yanqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1a0c4a4549e1c0cf47a5a13d754e7f63b958a1fcf4ab6a5c811dcfb6f3fa31f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Brain - physiopathology</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Female</topic><topic>Follow-up</topic><topic>Follow-Up Studies</topic><topic>Frontal Lobe - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parietal Lobe - physiopathology</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Regional homogeneity</topic><topic>Resting-state fMRI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Xiaowei</creatorcontrib><creatorcontrib>Fu, Shinan</creatorcontrib><creatorcontrib>Yin, Zhiyang</creatorcontrib><creatorcontrib>Kang, Jiahui</creatorcontrib><creatorcontrib>Wang, Xinrui</creatorcontrib><creatorcontrib>Zhou, Yifang</creatorcontrib><creatorcontrib>Wei, Shengnan</creatorcontrib><creatorcontrib>Wu, Feng</creatorcontrib><creatorcontrib>Kong, Lingtao</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Tang, Yanqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Xiaowei</au><au>Fu, Shinan</au><au>Yin, Zhiyang</au><au>Kang, Jiahui</au><au>Wang, Xinrui</au><au>Zhou, Yifang</au><au>Wei, Shengnan</au><au>Wu, Feng</au><au>Kong, Lingtao</au><au>Wang, Fei</au><au>Tang, Yanqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: Preliminary findings from a follow-up resting state fMRI study</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>260</volume><spage>653</spage><epage>659</epage><pages>653-659</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•Changes in FPN may provide common and distinct markers to affective disorders.•Changes in right-side frontal cortex may distinguish BD from MDD and HC.•Changes in parietal cortex may be the commonality of affective disorders.•Patient groups showed different neural patterns in the frontal and parietal cortex.•ReHo is a sensitive method to detect neuroactivities in FE-affective disorders.
It is difficult to distinguish bipolar disorder (BD) from major depressive disorder (MDD), especially with the initial depressive episode. In this study, we compared neural activities of BD and MDD patients during the first-episode (FE) to investigate common and distinct neural activities and further explore predictive indicators in the two diseases.
FE-MDD patients were performed resting state functional magnetic resonance imaging and followed up after scanning. After follow-up, FE-MDD patients were regrouped into FE-BD and FE-MDD patients. The study included 24 FE-BD patients, 28 FE-MDD patients, and 30 age- and sex-matched healthy controls (HC) to investigate neural activities with regional homogeneity (ReHo) analysis among the 3 groups.
Compared to HC, FE-BD patients displayed significantly higher ReHo values in the superior frontal gyrus, the medial superior frontal gyrus within right-side cerebral hemisphere than FE-MDD patients and HC. Compared to HC, FE-BD and FE-MDD patients displayed significant decreased ReHo values in the paracentral lobule, the precuneus and the median cingulate and paracingulate gyrus within bilateral cerebral hemisphere, and the postcentral gyrus and the precentral gyrus within the right-side. FE-BD displayed significant lower ReHo values than FE-MDD patients in these regions.
The potential effects of medicine, age, course of disease and handedness on results could not be ignored.
Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of affective disorders.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31542559</pmid><doi>10.1016/j.jad.2019.09.063</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Bipolar disorder Bipolar Disorder - physiopathology Brain - physiopathology Depressive Disorder, Major - physiopathology Female Follow-up Follow-Up Studies Frontal Lobe - physiopathology Humans Magnetic Resonance Imaging Major depressive disorder Male Middle Aged Parietal Lobe - physiopathology Prefrontal Cortex - physiopathology Regional homogeneity Resting-state fMRI |
| title | Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: Preliminary findings from a follow-up resting state fMRI study |
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