The lncRNA EGFR-AS1 is linked to migration, invasion and apoptosis in glioma cells by targeting miR-133b/RACK1

•MiR-133b inhibits migration, invasion and induces apoptosis in glioma cells, and was decreased by EGFR-AS1.•RACK1 promotes metastasis in glioma cells and is suppressed by miR-133b.•MiR-133b/RACK1 regulates the tumor-inhibitory role of EGFR-AS1 knockdown in glioma cells. Glioblastoma multiforme (GBM...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-10, Vol.118, p.109292-109292, Article 109292
Hauptverfasser:	Dong, Zhi-Qiang, Guo, Zhao-Yu, Xie, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Base Sequence Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics EGFR-AS1 Gene Expression Regulation, Neoplastic Glioblastoma Glioma - genetics Glioma - pathology Humans Male Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Migration, invasion and apoptosis miR-133b Neoplasm Invasiveness Neoplasm Proteins - genetics Neoplasm Proteins - metabolism RACK1 Receptors for Activated C Kinase - genetics Receptors for Activated C Kinase - metabolism Xenograft Model Antitumor Assays
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