RAD18 contributes to the migration and invasion of human cervical cancer cells via the interleukin‑1β pathway

The E3 ubiquitin ligase RAD18 has been identified as an oncoprotein that exhibits prometastatic properties in various types of cancer; however, the role of RAD18 in cervical cancer (CC) remains unclear. In the present study, it was revealed that increased expression of RAD18 was associated with wors...

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Veröffentlicht in:	Molecular medicine reports 2019-10, Vol.20 (4), p.3415-3423
Hauptverfasser:	Lou, Pengrong, Zou, Shitao, Shang, Zengfu, He, Chao, Gao, Aidi, Hou, Shunyu, Zhou, Jundong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens Cell adhesion & migration Cell growth Cell Movement Cervical cancer Cervix Cytokines Deoxyribonucleic acid DNA DNA damage DNA polymerase DNA-Binding Proteins - metabolism Female Genomes Humans IL-1β Inflammation Interleukin-1beta - metabolism Invasiveness Lymphatic system Medical prognosis Melanoma Metastasis Middle Aged mRNA Neoplasm Invasiveness Neoplasm Proteins - metabolism Patients Signal Transduction Therapeutic applications Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Viral infections
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