Antiparasitic activities of new lawsone Mannich bases

A series of new lawsone Mannich bases derived from salicylaldehydes or nitrofurfural were prepared and tested for their activities against Leishmania major, Toxoplasma gondii, and Trypanosoma brucei brucei parasites. The hydrochloride salts 5a and 6a of the Mannich bases 2a and 3a, derived from unsu...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2019-11, Vol.352 (11), p.e1900128-n/a
Hauptverfasser:	Al Nasr, Ibrahim, Jentzsch, Jana, Winter, Isabel, Schobert, Rainer, Ersfeld, Klaus, Koko, Waleed S., Mujawah, Adil A. H., Khan, Tariq A., Biersack, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiparasitic Agents - chemical synthesis Antiparasitic Agents - chemistry Antiparasitic Agents - pharmacology antiparasitic drugs Dose-Response Relationship, Drug lawsone Leishmania major - drug effects Mannich base Mannich Bases - chemical synthesis Mannich Bases - chemistry Mannich Bases - pharmacology Molecular Structure Naphthoquinones - chemical synthesis Naphthoquinones - chemistry Naphthoquinones - pharmacology neglected tropical diseases Parasitic Sensitivity Tests Protozoa salicyl derivatives Structure-Activity Relationship Toxoplasma - drug effects Trypanosoma brucei brucei - drug effects
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