Lack of association between appendectomy and Parkinson’s disease: a systematic review and meta-analysis

Background Accumulation of aggregated α-synuclein from the enteric nervous system is believed to be involved in the pathogenesis of Parkinson’s disease (PD). The appendix contains abundant α-synuclein and lacks a blood–tissue barrier, suggesting that appendectomy might reduce α-synuclein aggregation...

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