tert‐Butyl Nitrite (TBN), a Multitasking Reagent in Organic Synthesis

The upsurge interest in the development of efficient methodologies for the construction of nitrogen‐containing frameworks via the use of expedient reagents have been creating a renaissance in contemporary organic chemistry. In this perspective, tertbutyl nitrite (TBN) is an emerging building block. Due to its unique structural features, it shows differential reactivity under different reaction conditions. These diverse reactivities have resulted in the construction of a diverse array of complex N‐containing molecules. The primary objective of the present review is to bring the latest findings of TBN in terms of its applications in reactions (oxidation, diazotization, nitrosation, nitration, oximation, N‐synthon, and miscellaneous reactions) into the limelight. For simplicity and brevity, reactions in each section are explained with the mechanism of formation and selected examples are given. Multitasking at work: This encyclopedic review summarizes the latest findings of the emerging multitask reagent TBN in organic synthesis.