Role of liraglutide in brain repair promotion through Sirt1‐mediated mitochondrial improvement in stroke

Brain repair, especially axonal sprouting, is critical to restore motor function in disabled stroke patients. Liraglutide (LG) is a new kind of long‐acting analogue of glucagon‐like peptide‐1 (GLP‐1) and has potential protective effects in stroke. The mitochondria participate in brain repair after c...

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Veröffentlicht in:	Journal of cellular physiology 2020-03, Vol.235 (3), p.2986-3001
Hauptverfasser:	He, Weiliang, Wang, Haoyuan, Zhao, Congying, Tian, Xiaochao, Li, Litao, Wang, Hebo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Animals Antidiabetics ATP Autophagy - drug effects Axon sprouting Brain Brain injury brain repair Cell survival Cell Survival - drug effects Dehydrogenase Dehydrogenases Glucagon Human motion Hydrogen peroxide Injuries Ischemia Isocitrate dehydrogenase Ketoglutaric acid liraglutide Liraglutide - pharmacology Membrane potential Membrane Potential, Mitochondrial - drug effects Mice, Inbred C57BL Mitochondria Mitochondria - drug effects Mitochondria - metabolism Neurons Neurons - drug effects Neurons - metabolism Oxoglutarate dehydrogenase (lipoamide) Reactive oxygen species Reactive Oxygen Species - metabolism Recovery of function Repair Ribonucleic acid RNA Signal Transduction - drug effects siRNA Sirt1 SIRT1 protein Sirtuin 1 - drug effects Sirtuin 1 - metabolism Stroke Stroke - metabolism Succinate dehydrogenase Survival
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