Peripheral Blood B and T Cell Profiles in Children with Active Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is one of the most common autoimmune diseases in children. Our study aimed to evaluate the peripheral blood B and T lymphocyte subpopulations in children with JIA. This case–control study included 20 children with JIA as well as 20 healthy children with matching a...
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| Veröffentlicht in: | Archivum Immunologiae et Therapiae Experimentalis 2019-12, Vol.67 (6), p.427-432 |
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| creator | Zahran, Asmaa M. Abdallah, Alameldin M. Saad, Khaled Osman, Naglaa S. Youssef, Mervat A. M. Abdel-Raheem, Yasser Farouk Elsayh, Khalid I. Abo Elgheet, Amir M. Darwish, Sanaa F. Alblihed, Mohamd A. Elhoufey, Amira |
| description | Juvenile idiopathic arthritis (JIA) is one of the most common autoimmune diseases in children. Our study aimed to evaluate the peripheral blood B and T lymphocyte subpopulations in children with JIA. This case–control study included 20 children with JIA as well as 20 healthy children with matching age and sex as a control group. All patients included in the study were in activity as determined by visual analog scale. In addition to complete clinical evaluation, basic investigations, peripheral blood B and T lymphocyte subpopulations were done to all participants by flow cytometry. JIA patients displayed a significant decrease in IgM memory B lymphocytes, switched memory B lymphocytes, and total memory B lymphocytes when compared to the healthy controls. The percentages of naïve B lymphocytes were significantly increased in JIA patients than in controls. Total T lymphocytes, CD8
+
CD28
null
cells, and CD4
+
CD28
null
cells were significantly increased in JIA patients as compared to controls. In conclusion; JIA patients have an alteration in both B and T lymphocytes with the predisposition of memory cells which may have a role in sustaining the JIA disease activity. |
| doi_str_mv | 10.1007/s00005-019-00560-7 |
| format | Article |
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+
CD28
null
cells, and CD4
+
CD28
null
cells were significantly increased in JIA patients as compared to controls. In conclusion; JIA patients have an alteration in both B and T lymphocytes with the predisposition of memory cells which may have a role in sustaining the JIA disease activity.</description><identifier>ISSN: 0004-069X</identifier><identifier>EISSN: 1661-4917</identifier><identifier>DOI: 10.1007/s00005-019-00560-7</identifier><identifier>PMID: 31535168</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adolescent ; Arthritis ; Arthritis, Juvenile - immunology ; Autoimmune diseases ; B-Lymphocytes - immunology ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; CD28 antigen ; CD4 antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Child ; Children ; Disease Progression ; Female ; Flow Cytometry ; Humans ; Immunoglobulin M ; Immunoglobulin M - metabolism ; Immunologic Memory ; Immunology ; Lymphocyte Subsets - immunology ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Male ; Memory cells ; Original Article ; Peripheral blood ; Pharmacology/Toxicology ; Visual Analog Scale</subject><ispartof>Archivum Immunologiae et Therapiae Experimentalis, 2019-12, Vol.67 (6), p.427-432</ispartof><rights>L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-aad390adc72cd3d219e1e744f4d76b181abc2c2df09434a2bbbf18d62fd7c4033</citedby><cites>FETCH-LOGICAL-c375t-aad390adc72cd3d219e1e744f4d76b181abc2c2df09434a2bbbf18d62fd7c4033</cites><orcidid>0000-0002-8473-6116</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00005-019-00560-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00005-019-00560-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31535168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zahran, Asmaa M.</creatorcontrib><creatorcontrib>Abdallah, Alameldin M.</creatorcontrib><creatorcontrib>Saad, Khaled</creatorcontrib><creatorcontrib>Osman, Naglaa S.</creatorcontrib><creatorcontrib>Youssef, Mervat A. M.</creatorcontrib><creatorcontrib>Abdel-Raheem, Yasser Farouk</creatorcontrib><creatorcontrib>Elsayh, Khalid I.</creatorcontrib><creatorcontrib>Abo Elgheet, Amir M.</creatorcontrib><creatorcontrib>Darwish, Sanaa F.</creatorcontrib><creatorcontrib>Alblihed, Mohamd A.</creatorcontrib><creatorcontrib>Elhoufey, Amira</creatorcontrib><title>Peripheral Blood B and T Cell Profiles in Children with Active Juvenile Idiopathic Arthritis</title><title>Archivum Immunologiae et Therapiae Experimentalis</title><addtitle>Arch. Immunol. Ther. Exp</addtitle><addtitle>Arch Immunol Ther Exp (Warsz)</addtitle><description>Juvenile idiopathic arthritis (JIA) is one of the most common autoimmune diseases in children. Our study aimed to evaluate the peripheral blood B and T lymphocyte subpopulations in children with JIA. This case–control study included 20 children with JIA as well as 20 healthy children with matching age and sex as a control group. All patients included in the study were in activity as determined by visual analog scale. In addition to complete clinical evaluation, basic investigations, peripheral blood B and T lymphocyte subpopulations were done to all participants by flow cytometry. JIA patients displayed a significant decrease in IgM memory B lymphocytes, switched memory B lymphocytes, and total memory B lymphocytes when compared to the healthy controls. The percentages of naïve B lymphocytes were significantly increased in JIA patients than in controls. Total T lymphocytes, CD8
+
CD28
null
cells, and CD4
+
CD28
null
cells were significantly increased in JIA patients as compared to controls. In conclusion; JIA patients have an alteration in both B and T lymphocytes with the predisposition of memory cells which may have a role in sustaining the JIA disease activity.</description><subject>Adolescent</subject><subject>Arthritis</subject><subject>Arthritis, Juvenile - immunology</subject><subject>Autoimmune diseases</subject><subject>B-Lymphocytes - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>CD28 antigen</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Child</subject><subject>Children</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulin M - metabolism</subject><subject>Immunologic Memory</subject><subject>Immunology</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Memory cells</subject><subject>Original Article</subject><subject>Peripheral blood</subject><subject>Pharmacology/Toxicology</subject><subject>Visual Analog Scale</subject><issn>0004-069X</issn><issn>1661-4917</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LwzAYx4Mobk6_gAcJePFSzVub9rgVXyYDd5jgQQhpktqMrp1JO_HbG91U8GAuT8Lze_55-AFwitElRohfeRROHCGcRaEmKOJ7YIiTBEcsw3wfDEObRSjJngbgyPtleNEYs0MwoDgOtyQdgue5cXZdGSdrOKnbVsMJlI2GC5ibuoZz15a2Nh7aBuaVrbUzDXyzXQXHqrMbA-_7jWkCAafatmvZVVbBsesqZzvrj8FBKWtvTnZ1BB5vrhf5XTR7uJ3m41mkKI-7SEpNMyS14kRpqgnODDacsZJpnhQ4xbJQRBFdooxRJklRFCVOdUJKzRVDlI7AxTZ37drX3vhOrKxXYX_ZmLb3gpCMZikigR2B8z_osu1dE7YThCLOExKncaDIllKu9d6ZUqydXUn3LjASn-7F1r0I7sWXe8HD0Nkuui9WRv-MfMsOAN0CPrSaF-N-__4n9gPyj45B</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Zahran, Asmaa M.</creator><creator>Abdallah, Alameldin M.</creator><creator>Saad, Khaled</creator><creator>Osman, Naglaa S.</creator><creator>Youssef, Mervat A. M.</creator><creator>Abdel-Raheem, Yasser Farouk</creator><creator>Elsayh, Khalid I.</creator><creator>Abo Elgheet, Amir M.</creator><creator>Darwish, Sanaa F.</creator><creator>Alblihed, Mohamd A.</creator><creator>Elhoufey, Amira</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8473-6116</orcidid></search><sort><creationdate>20191201</creationdate><title>Peripheral Blood B and T Cell Profiles in Children with Active Juvenile Idiopathic Arthritis</title><author>Zahran, Asmaa M. ; Abdallah, Alameldin M. ; Saad, Khaled ; Osman, Naglaa S. ; Youssef, Mervat A. M. ; Abdel-Raheem, Yasser Farouk ; Elsayh, Khalid I. ; Abo Elgheet, Amir M. ; Darwish, Sanaa F. ; Alblihed, Mohamd A. ; Elhoufey, Amira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-aad390adc72cd3d219e1e744f4d76b181abc2c2df09434a2bbbf18d62fd7c4033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Arthritis</topic><topic>Arthritis, Juvenile - immunology</topic><topic>Autoimmune diseases</topic><topic>B-Lymphocytes - immunology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Case-Control Studies</topic><topic>CD28 antigen</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Child</topic><topic>Children</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - metabolism</topic><topic>Immunologic Memory</topic><topic>Immunology</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Memory cells</topic><topic>Original Article</topic><topic>Peripheral blood</topic><topic>Pharmacology/Toxicology</topic><topic>Visual Analog Scale</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zahran, Asmaa M.</creatorcontrib><creatorcontrib>Abdallah, Alameldin M.</creatorcontrib><creatorcontrib>Saad, Khaled</creatorcontrib><creatorcontrib>Osman, Naglaa S.</creatorcontrib><creatorcontrib>Youssef, Mervat A. M.</creatorcontrib><creatorcontrib>Abdel-Raheem, Yasser Farouk</creatorcontrib><creatorcontrib>Elsayh, Khalid I.</creatorcontrib><creatorcontrib>Abo Elgheet, Amir M.</creatorcontrib><creatorcontrib>Darwish, Sanaa F.</creatorcontrib><creatorcontrib>Alblihed, Mohamd A.</creatorcontrib><creatorcontrib>Elhoufey, Amira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Archivum Immunologiae et Therapiae Experimentalis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zahran, Asmaa M.</au><au>Abdallah, Alameldin M.</au><au>Saad, Khaled</au><au>Osman, Naglaa S.</au><au>Youssef, Mervat A. M.</au><au>Abdel-Raheem, Yasser Farouk</au><au>Elsayh, Khalid I.</au><au>Abo Elgheet, Amir M.</au><au>Darwish, Sanaa F.</au><au>Alblihed, Mohamd A.</au><au>Elhoufey, Amira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral Blood B and T Cell Profiles in Children with Active Juvenile Idiopathic Arthritis</atitle><jtitle>Archivum Immunologiae et Therapiae Experimentalis</jtitle><stitle>Arch. Immunol. Ther. Exp</stitle><addtitle>Arch Immunol Ther Exp (Warsz)</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>67</volume><issue>6</issue><spage>427</spage><epage>432</epage><pages>427-432</pages><issn>0004-069X</issn><eissn>1661-4917</eissn><abstract>Juvenile idiopathic arthritis (JIA) is one of the most common autoimmune diseases in children. Our study aimed to evaluate the peripheral blood B and T lymphocyte subpopulations in children with JIA. This case–control study included 20 children with JIA as well as 20 healthy children with matching age and sex as a control group. All patients included in the study were in activity as determined by visual analog scale. In addition to complete clinical evaluation, basic investigations, peripheral blood B and T lymphocyte subpopulations were done to all participants by flow cytometry. JIA patients displayed a significant decrease in IgM memory B lymphocytes, switched memory B lymphocytes, and total memory B lymphocytes when compared to the healthy controls. The percentages of naïve B lymphocytes were significantly increased in JIA patients than in controls. Total T lymphocytes, CD8
+
CD28
null
cells, and CD4
+
CD28
null
cells were significantly increased in JIA patients as compared to controls. In conclusion; JIA patients have an alteration in both B and T lymphocytes with the predisposition of memory cells which may have a role in sustaining the JIA disease activity.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31535168</pmid><doi>10.1007/s00005-019-00560-7</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8473-6116</orcidid></addata></record> |
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| subjects | Adolescent Arthritis Arthritis, Juvenile - immunology Autoimmune diseases B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Case-Control Studies CD28 antigen CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Child Children Disease Progression Female Flow Cytometry Humans Immunoglobulin M Immunoglobulin M - metabolism Immunologic Memory Immunology Lymphocyte Subsets - immunology Lymphocytes Lymphocytes B Lymphocytes T Male Memory cells Original Article Peripheral blood Pharmacology/Toxicology Visual Analog Scale |
| title | Peripheral Blood B and T Cell Profiles in Children with Active Juvenile Idiopathic Arthritis |
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