Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis

Enhanced gut permeability due to dysregulated epithelial tight junction is often associated with inflammatory bowel diseases (IBD), which have a greater risk for developing colorectal cancer. STAT6 activation was detected in inflamed colonic epithelium of active IBD patients, suggesting a role of ep...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Mucosal immunology 2019-11, Vol.12 (6), p.1304-1315
Hauptverfasser:	Lin, Yuli, Li, Bingji, Yang, Xuguang, Liu, Ting, Shi, Tiancong, Deng, Bo, Zhang, Yubin, Jia, Lijun, Jiang, Zhengfan, He, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Animals Antibodies Bacterial Translocation Biomedical and Life Sciences Biomedicine Caco-2 Cells Cancer Colitis Colitis - genetics Colitis - metabolism Colitis - microbiology Colitis - pathology Colon - drug effects Colon - metabolism Colon - microbiology Colon - pathology Colonic Neoplasms - metabolism Colonic Neoplasms - microbiology Colonic Neoplasms - pathology Colonic Neoplasms - prevention & control Colorectal cancer Colorectal carcinoma Digestive system Disease Models, Animal Electric Impedance Epithelium Gastroenterology Gastrointestinal Microbiome Gastrointestinal tract Genes, APC Humans Immunology Inflammatory bowel disease Inflammatory bowel diseases Interleukin 13 Interleukin-13 - metabolism Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Intestine Lymphocytes - metabolism Lymphocytes - pathology Lymphoid cells Mice, 129 Strain Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microbiota Myosin Myosin-light-chain kinase Myosin-Light-Chain Kinase - genetics Myosin-Light-Chain Kinase - metabolism Permeability Phosphorylation Pyrimidines - pharmacology Signal Transduction Stat6 protein STAT6 Transcription Factor - antagonists & inhibitors STAT6 Transcription Factor - deficiency STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism Tight Junctions - drug effects Tight Junctions - metabolism Tight Junctions - microbiology Tight Junctions - pathology Tissue Culture Techniques Tumorigenesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!