Role of skeletal muscle autophagy in high-fat-diet-induced obesity and exercise

Role of skeletal muscle autophagy in high-fat-diet-induced obesity and exercise

Autophagy is a complex degradation pathway responsible for clearing damaged and dysfunctional organelles. High-fat-diet-induced obesity has been shown to alter autophagy throughout the body in a tissue-specific manner. The impact of obesity on skeletal muscle autophagy has yet to be elucidated. This...

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Veröffentlicht in:Nutrition reviews 2020-01, Vol.78 (1), p.56-64
Hauptverfasser: Herrenbruck, Adrienne R, Bollinger, Lance M
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creator Herrenbruck, Adrienne R
Bollinger, Lance M
description Autophagy is a complex degradation pathway responsible for clearing damaged and dysfunctional organelles. High-fat-diet-induced obesity has been shown to alter autophagy throughout the body in a tissue-specific manner. The impact of obesity on skeletal muscle autophagy has yet to be elucidated. This review examines the impact of high-fat-diet-induced obesity and exercise on skeletal muscle autophagy. Better understanding this major quality control mechanism may help develop novel therapies to combat high-fat-diet-induced obesity comorbidities.
doi_str_mv 10.1093/nutrit/nuz044
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source Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
title Role of skeletal muscle autophagy in high-fat-diet-induced obesity and exercise
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