Multidrug‐resistant bacterial infections in children undergoing haematopoietic stem cell transplantation over a 6‐year period: analysis of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation
Aims Multidrug‐resistant (MDR) bacteria are an emerging cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT). The aim of the study was to analyse the incidence, clinical characteristics and survival from bacterial infections (BI) caused by MDR pathogens in paediatri...
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| Veröffentlicht in: | Journal of applied microbiology 2020-01, Vol.128 (1), p.292-300 |
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| creator | Zając‐Spychała, O. Wachowiak, J. Frączkiewicz, J. Salamonowicz, M. Kałwak, K. Gorczyńska, E. Chybicka, A. Czyżewski, K. Dziedzic, M. Wysocki, M. Zalas‐Wiącek, P. Zaucha‐Prażmo, A. Kowalczyk, J.R. Goździk, J. Styczyński, J. |
| description | Aims
Multidrug‐resistant (MDR) bacteria are an emerging cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT). The aim of the study was to analyse the incidence, clinical characteristics and survival from bacterial infections (BI) caused by MDR pathogens in paediatric HSCT recipients.
Methods and Results
Among 971 transplanted patients, BI were found in 416 children between the years 2012 and 2017. Overall, there were 883 bacterial episodes, which includes 85·8% after allo‐HSCT and 14·2% after auto‐HSCT. MDR strains were responsible for half of the total number of bacterial episodes. Over 50% of MDR pathogens were Enterobacteriaceae causing mainly gut infections or urinary tract infections.
Conclusions
Regarding HSCT type, we did not find differences in the profile of MDR BI between allo‐ and auto‐HSCT recipients. However, survival in MDR and non‐MDR infections was comparable.
Significance and Impact of the Study
The large sample size enables unique analysis and makes our data more applicable to other paediatric HSCT centres. In the absence of local epidemiological data, presented clinical characteristics of MDR‐caused infections may be used to optimize the prophylactic strategies, early identification of infectious complications of MDR aetiology and thus promptly initiate adequate antibiotic therapy and further improve patients’ outcome. |
| doi_str_mv | 10.1111/jam.14452 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2293003495</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2323225955</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-6a5ff213bc18e33ceaab8c76e9a32836f0f535cbd9f7e4e3572f966f41fb12543</originalsourceid><addsrcrecordid>eNp1kc1u1DAURiNERUthwQsgS2xgkTa2Y2fCrhrRP7WiEmUd3TjXMx45cbAd0Oz6CLwcL8CT4HRapCLhu_BdHH1HV1-WvaHFEU3veAP9ES1LwZ5lB5RLkTNZsef3e5mLomL72csQNkVBeSHki2yfU8FqIeRB9ut6stF0flr9vvvpMZgQYYikBRXRG7DEDBpVNG4IaSVqbWzncSDT0KFfOTOsyBqwh-hGZzAaRULEnii0lkQPQxhtyoM5gLjv6AkQmUxbBE_GZHDdRwID2G0yE6dJXCO5cdaENbnBzkD0KfLMu2kk2nly_kT1ZVYtZ9XtU9WrbE-DDfj64T_Mvp5-ul2e51efzy6WJ1e54oKzXILQmlHeKrpAzhUCtAtVSayBswWXutCCC9V2ta6wRC4qpmspdUl1S5ko-WH2fpc7evdtwhCb3oT5dhjQTaFhrOZFwctaJPTdP-jGTT5dniieholUSKI-7CjlXQgedTN604PfNrRo5q6b1HVz33Vi3z4kTm2P3V_ysdwEHO-AH8bi9v9JzeXJ9S7yD5xcurg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2323225955</pqid></control><display><type>article</type><title>Multidrug‐resistant bacterial infections in children undergoing haematopoietic stem cell transplantation over a 6‐year period: analysis of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zając‐Spychała, O. ; Wachowiak, J. ; Frączkiewicz, J. ; Salamonowicz, M. ; Kałwak, K. ; Gorczyńska, E. ; Chybicka, A. ; Czyżewski, K. ; Dziedzic, M. ; Wysocki, M. ; Zalas‐Wiącek, P. ; Zaucha‐Prażmo, A. ; Kowalczyk, J.R. ; Goździk, J. ; Styczyński, J.</creator><creatorcontrib>Zając‐Spychała, O. ; Wachowiak, J. ; Frączkiewicz, J. ; Salamonowicz, M. ; Kałwak, K. ; Gorczyńska, E. ; Chybicka, A. ; Czyżewski, K. ; Dziedzic, M. ; Wysocki, M. ; Zalas‐Wiącek, P. ; Zaucha‐Prażmo, A. ; Kowalczyk, J.R. ; Goździk, J. ; Styczyński, J.</creatorcontrib><description>Aims
Multidrug‐resistant (MDR) bacteria are an emerging cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT). The aim of the study was to analyse the incidence, clinical characteristics and survival from bacterial infections (BI) caused by MDR pathogens in paediatric HSCT recipients.
Methods and Results
Among 971 transplanted patients, BI were found in 416 children between the years 2012 and 2017. Overall, there were 883 bacterial episodes, which includes 85·8% after allo‐HSCT and 14·2% after auto‐HSCT. MDR strains were responsible for half of the total number of bacterial episodes. Over 50% of MDR pathogens were Enterobacteriaceae causing mainly gut infections or urinary tract infections.
Conclusions
Regarding HSCT type, we did not find differences in the profile of MDR BI between allo‐ and auto‐HSCT recipients. However, survival in MDR and non‐MDR infections was comparable.
Significance and Impact of the Study
The large sample size enables unique analysis and makes our data more applicable to other paediatric HSCT centres. In the absence of local epidemiological data, presented clinical characteristics of MDR‐caused infections may be used to optimize the prophylactic strategies, early identification of infectious complications of MDR aetiology and thus promptly initiate adequate antibiotic therapy and further improve patients’ outcome.</description><identifier>ISSN: 1364-5072</identifier><identifier>EISSN: 1365-2672</identifier><identifier>DOI: 10.1111/jam.14452</identifier><identifier>PMID: 31529556</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacteria ; Bacteria - classification ; Bacteria - drug effects ; Bacteria - isolation & purification ; Bacterial diseases ; Bacterial infections ; Bacterial Infections - epidemiology ; Bacterial Infections - microbiology ; Child ; Child, Preschool ; Children ; disease ; Drug resistance ; Drug Resistance, Multiple, Bacterial ; Epidemiology ; Female ; haematopoietic stem cell transplantation infection ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - statistics & numerical data ; Hematopoietic stem cells ; Humans ; Incidence ; Infant ; Infections ; Male ; Morbidity ; Multidrug resistant organisms ; Pathogens ; Patients ; Poland - epidemiology ; resistance ; Stem cell transplantation ; Stem cells ; Survival ; Survival Analysis ; Transplantation ; Urinary tract ; Young Adult</subject><ispartof>Journal of applied microbiology, 2020-01, Vol.128 (1), p.292-300</ispartof><rights>2019 The Society for Applied Microbiology</rights><rights>2019 The Society for Applied Microbiology.</rights><rights>Copyright © 2020 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-6a5ff213bc18e33ceaab8c76e9a32836f0f535cbd9f7e4e3572f966f41fb12543</citedby><cites>FETCH-LOGICAL-c3532-6a5ff213bc18e33ceaab8c76e9a32836f0f535cbd9f7e4e3572f966f41fb12543</cites><orcidid>0000-0002-8836-8605</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjam.14452$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjam.14452$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31529556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zając‐Spychała, O.</creatorcontrib><creatorcontrib>Wachowiak, J.</creatorcontrib><creatorcontrib>Frączkiewicz, J.</creatorcontrib><creatorcontrib>Salamonowicz, M.</creatorcontrib><creatorcontrib>Kałwak, K.</creatorcontrib><creatorcontrib>Gorczyńska, E.</creatorcontrib><creatorcontrib>Chybicka, A.</creatorcontrib><creatorcontrib>Czyżewski, K.</creatorcontrib><creatorcontrib>Dziedzic, M.</creatorcontrib><creatorcontrib>Wysocki, M.</creatorcontrib><creatorcontrib>Zalas‐Wiącek, P.</creatorcontrib><creatorcontrib>Zaucha‐Prażmo, A.</creatorcontrib><creatorcontrib>Kowalczyk, J.R.</creatorcontrib><creatorcontrib>Goździk, J.</creatorcontrib><creatorcontrib>Styczyński, J.</creatorcontrib><title>Multidrug‐resistant bacterial infections in children undergoing haematopoietic stem cell transplantation over a 6‐year period: analysis of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation</title><title>Journal of applied microbiology</title><addtitle>J Appl Microbiol</addtitle><description>Aims
Multidrug‐resistant (MDR) bacteria are an emerging cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT). The aim of the study was to analyse the incidence, clinical characteristics and survival from bacterial infections (BI) caused by MDR pathogens in paediatric HSCT recipients.
Methods and Results
Among 971 transplanted patients, BI were found in 416 children between the years 2012 and 2017. Overall, there were 883 bacterial episodes, which includes 85·8% after allo‐HSCT and 14·2% after auto‐HSCT. MDR strains were responsible for half of the total number of bacterial episodes. Over 50% of MDR pathogens were Enterobacteriaceae causing mainly gut infections or urinary tract infections.
Conclusions
Regarding HSCT type, we did not find differences in the profile of MDR BI between allo‐ and auto‐HSCT recipients. However, survival in MDR and non‐MDR infections was comparable.
Significance and Impact of the Study
The large sample size enables unique analysis and makes our data more applicable to other paediatric HSCT centres. In the absence of local epidemiological data, presented clinical characteristics of MDR‐caused infections may be used to optimize the prophylactic strategies, early identification of infectious complications of MDR aetiology and thus promptly initiate adequate antibiotic therapy and further improve patients’ outcome.</description><subject>Adolescent</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacteria - classification</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - isolation & purification</subject><subject>Bacterial diseases</subject><subject>Bacterial infections</subject><subject>Bacterial Infections - epidemiology</subject><subject>Bacterial Infections - microbiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>disease</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Epidemiology</subject><subject>Female</subject><subject>haematopoietic stem cell transplantation infection</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic Stem Cell Transplantation - statistics & numerical data</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infections</subject><subject>Male</subject><subject>Morbidity</subject><subject>Multidrug resistant organisms</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Poland - epidemiology</subject><subject>resistance</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Transplantation</subject><subject>Urinary tract</subject><subject>Young Adult</subject><issn>1364-5072</issn><issn>1365-2672</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAURiNERUthwQsgS2xgkTa2Y2fCrhrRP7WiEmUd3TjXMx45cbAd0Oz6CLwcL8CT4HRapCLhu_BdHH1HV1-WvaHFEU3veAP9ES1LwZ5lB5RLkTNZsef3e5mLomL72csQNkVBeSHki2yfU8FqIeRB9ut6stF0flr9vvvpMZgQYYikBRXRG7DEDBpVNG4IaSVqbWzncSDT0KFfOTOsyBqwh-hGZzAaRULEnii0lkQPQxhtyoM5gLjv6AkQmUxbBE_GZHDdRwID2G0yE6dJXCO5cdaENbnBzkD0KfLMu2kk2nly_kT1ZVYtZ9XtU9WrbE-DDfj64T_Mvp5-ul2e51efzy6WJ1e54oKzXILQmlHeKrpAzhUCtAtVSayBswWXutCCC9V2ta6wRC4qpmspdUl1S5ko-WH2fpc7evdtwhCb3oT5dhjQTaFhrOZFwctaJPTdP-jGTT5dniieholUSKI-7CjlXQgedTN604PfNrRo5q6b1HVz33Vi3z4kTm2P3V_ysdwEHO-AH8bi9v9JzeXJ9S7yD5xcurg</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Zając‐Spychała, O.</creator><creator>Wachowiak, J.</creator><creator>Frączkiewicz, J.</creator><creator>Salamonowicz, M.</creator><creator>Kałwak, K.</creator><creator>Gorczyńska, E.</creator><creator>Chybicka, A.</creator><creator>Czyżewski, K.</creator><creator>Dziedzic, M.</creator><creator>Wysocki, M.</creator><creator>Zalas‐Wiącek, P.</creator><creator>Zaucha‐Prażmo, A.</creator><creator>Kowalczyk, J.R.</creator><creator>Goździk, J.</creator><creator>Styczyński, J.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8836-8605</orcidid></search><sort><creationdate>202001</creationdate><title>Multidrug‐resistant bacterial infections in children undergoing haematopoietic stem cell transplantation over a 6‐year period: analysis of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation</title><author>Zając‐Spychała, O. ; Wachowiak, J. ; Frączkiewicz, J. ; Salamonowicz, M. ; Kałwak, K. ; Gorczyńska, E. ; Chybicka, A. ; Czyżewski, K. ; Dziedzic, M. ; Wysocki, M. ; Zalas‐Wiącek, P. ; Zaucha‐Prażmo, A. ; Kowalczyk, J.R. ; Goździk, J. ; Styczyński, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-6a5ff213bc18e33ceaab8c76e9a32836f0f535cbd9f7e4e3572f966f41fb12543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Bacteria - classification</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - isolation & purification</topic><topic>Bacterial diseases</topic><topic>Bacterial infections</topic><topic>Bacterial Infections - epidemiology</topic><topic>Bacterial Infections - microbiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>disease</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Epidemiology</topic><topic>Female</topic><topic>haematopoietic stem cell transplantation infection</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic Stem Cell Transplantation - statistics & numerical data</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infections</topic><topic>Male</topic><topic>Morbidity</topic><topic>Multidrug resistant organisms</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Poland - epidemiology</topic><topic>resistance</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Transplantation</topic><topic>Urinary tract</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zając‐Spychała, O.</creatorcontrib><creatorcontrib>Wachowiak, J.</creatorcontrib><creatorcontrib>Frączkiewicz, J.</creatorcontrib><creatorcontrib>Salamonowicz, M.</creatorcontrib><creatorcontrib>Kałwak, K.</creatorcontrib><creatorcontrib>Gorczyńska, E.</creatorcontrib><creatorcontrib>Chybicka, A.</creatorcontrib><creatorcontrib>Czyżewski, K.</creatorcontrib><creatorcontrib>Dziedzic, M.</creatorcontrib><creatorcontrib>Wysocki, M.</creatorcontrib><creatorcontrib>Zalas‐Wiącek, P.</creatorcontrib><creatorcontrib>Zaucha‐Prażmo, A.</creatorcontrib><creatorcontrib>Kowalczyk, J.R.</creatorcontrib><creatorcontrib>Goździk, J.</creatorcontrib><creatorcontrib>Styczyński, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zając‐Spychała, O.</au><au>Wachowiak, J.</au><au>Frączkiewicz, J.</au><au>Salamonowicz, M.</au><au>Kałwak, K.</au><au>Gorczyńska, E.</au><au>Chybicka, A.</au><au>Czyżewski, K.</au><au>Dziedzic, M.</au><au>Wysocki, M.</au><au>Zalas‐Wiącek, P.</au><au>Zaucha‐Prażmo, A.</au><au>Kowalczyk, J.R.</au><au>Goździk, J.</au><au>Styczyński, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidrug‐resistant bacterial infections in children undergoing haematopoietic stem cell transplantation over a 6‐year period: analysis of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation</atitle><jtitle>Journal of applied microbiology</jtitle><addtitle>J Appl Microbiol</addtitle><date>2020-01</date><risdate>2020</risdate><volume>128</volume><issue>1</issue><spage>292</spage><epage>300</epage><pages>292-300</pages><issn>1364-5072</issn><eissn>1365-2672</eissn><abstract>Aims
Multidrug‐resistant (MDR) bacteria are an emerging cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT). The aim of the study was to analyse the incidence, clinical characteristics and survival from bacterial infections (BI) caused by MDR pathogens in paediatric HSCT recipients.
Methods and Results
Among 971 transplanted patients, BI were found in 416 children between the years 2012 and 2017. Overall, there were 883 bacterial episodes, which includes 85·8% after allo‐HSCT and 14·2% after auto‐HSCT. MDR strains were responsible for half of the total number of bacterial episodes. Over 50% of MDR pathogens were Enterobacteriaceae causing mainly gut infections or urinary tract infections.
Conclusions
Regarding HSCT type, we did not find differences in the profile of MDR BI between allo‐ and auto‐HSCT recipients. However, survival in MDR and non‐MDR infections was comparable.
Significance and Impact of the Study
The large sample size enables unique analysis and makes our data more applicable to other paediatric HSCT centres. In the absence of local epidemiological data, presented clinical characteristics of MDR‐caused infections may be used to optimize the prophylactic strategies, early identification of infectious complications of MDR aetiology and thus promptly initiate adequate antibiotic therapy and further improve patients’ outcome.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31529556</pmid><doi>10.1111/jam.14452</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8836-8605</orcidid></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacteria - classification Bacteria - drug effects Bacteria - isolation & purification Bacterial diseases Bacterial infections Bacterial Infections - epidemiology Bacterial Infections - microbiology Child Child, Preschool Children disease Drug resistance Drug Resistance, Multiple, Bacterial Epidemiology Female haematopoietic stem cell transplantation infection Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - statistics & numerical data Hematopoietic stem cells Humans Incidence Infant Infections Male Morbidity Multidrug resistant organisms Pathogens Patients Poland - epidemiology resistance Stem cell transplantation Stem cells Survival Survival Analysis Transplantation Urinary tract Young Adult |
| title | Multidrug‐resistant bacterial infections in children undergoing haematopoietic stem cell transplantation over a 6‐year period: analysis of the Polish Pediatric Group for Hematopoietic Stem Cell Transplantation |
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