Repolarization of M2 to M1 Macrophages Triggered by Lactate Oxidase Released from Methylcellulose Hydrogel
Deregulated proliferation of tumors is generally associated with altered energy metabolism. A high rate of anaerobic glycolysis in solid tumors contributes to an acidification of pH to ∼6.7–7.2 in the tumor microenvironment and lactate accumulation. Macrophages in the tumor microenvironment can be e...
Gespeichert in:
| Veröffentlicht in: | Bioconjugate chemistry 2019-10, Vol.30 (10), p.2697-2702 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2702 |
|---|---|
| container_issue | 10 |
| container_start_page | 2697 |
| container_title | Bioconjugate chemistry |
| container_volume | 30 |
| creator | Liao, Zi-Xian Fa, Yu-Chen Kempson, Ivan M Tseng, S.-Ja |
| description | Deregulated proliferation of tumors is generally associated with altered energy metabolism. A high rate of anaerobic glycolysis in solid tumors contributes to an acidification of pH to ∼6.7–7.2 in the tumor microenvironment and lactate accumulation. Macrophages in the tumor microenvironment can be educated by tumor cells. Tumor-derived lactate induces the polarization of M2 macrophages and promotes tumor invasion and metastasis. However, a particular challenge is to sustain lactate depletion. We propose that the repolarization of the tumor-supportive M2 macrophage to the tumor-suppressive M1 macrophage after the depletion of lactate by lactate oxidase (LOX) released from the hydrogels in the tumor microenvironment may enhance the antitumor treatment efficacy. |
| doi_str_mv | 10.1021/acs.bioconjchem.9b00618 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2292990108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2306795468</sourcerecordid><originalsourceid>FETCH-LOGICAL-a385t-e3fcf2e876a5ed5e0c3c43af20081daa30bf14821f5dba8d5390e6bf48de5b6b3</originalsourceid><addsrcrecordid>eNqFkU1rGzEQhkVJaT7av9AKcull3ZG0WmuPIbRJwCYQ0rPQx8hes2s50i7U_fWVsRtCLz3NwDzzzsu8hHxhMGPA2Tfj8sx20cXtxq1xmLUWoGHqHblgkkNVK8bPSg-1qJgCfk4uc94AQMsU_0DOBZOCs5ZfkM0T7mJvUvfbjF3c0hjoktMx0iWjS-NS3K3NCjN9Tt1qhQk9tXu6MG40I9LHX503GekT9liqpyHFgS5xXO97h30_9bFM7_c-xRX2H8n7YPqMn071ivz88f359r5aPN493N4sKiOUHCsUwQWOat4YiV4iOOFqYQIHUMwbI8AGVivOgvTWKC9FC9jYUCuP0jZWXJGvR91dii8T5lEPXT7YMVuMU9act7xtgYEq6PU_6CZOaVvcaS6gmbeybg7U_EiVd-ScMOhd6gaT9pqBPsShSxz6TRz6FEfZ_HzSn-yA_nXv7_8LII7AQeH19v9k_wCiyZ0-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2306795468</pqid></control><display><type>article</type><title>Repolarization of M2 to M1 Macrophages Triggered by Lactate Oxidase Released from Methylcellulose Hydrogel</title><source>ACS Publications</source><creator>Liao, Zi-Xian ; Fa, Yu-Chen ; Kempson, Ivan M ; Tseng, S.-Ja</creator><creatorcontrib>Liao, Zi-Xian ; Fa, Yu-Chen ; Kempson, Ivan M ; Tseng, S.-Ja</creatorcontrib><description>Deregulated proliferation of tumors is generally associated with altered energy metabolism. A high rate of anaerobic glycolysis in solid tumors contributes to an acidification of pH to ∼6.7–7.2 in the tumor microenvironment and lactate accumulation. Macrophages in the tumor microenvironment can be educated by tumor cells. Tumor-derived lactate induces the polarization of M2 macrophages and promotes tumor invasion and metastasis. However, a particular challenge is to sustain lactate depletion. We propose that the repolarization of the tumor-supportive M2 macrophage to the tumor-suppressive M1 macrophage after the depletion of lactate by lactate oxidase (LOX) released from the hydrogels in the tumor microenvironment may enhance the antitumor treatment efficacy.</description><identifier>ISSN: 1043-1802</identifier><identifier>EISSN: 1520-4812</identifier><identifier>DOI: 10.1021/acs.bioconjchem.9b00618</identifier><identifier>PMID: 31532192</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Acidification ; Anticancer properties ; Antitumor activity ; Depletion ; Deregulation ; Energy metabolism ; Glycolysis ; Hydrogels ; Lactate oxidase ; Lactic acid ; Liquid oxygen ; Macrophages ; Metastases ; Methylcellulose ; Oxidase ; Solid tumors ; Tumor cells ; Tumors</subject><ispartof>Bioconjugate chemistry, 2019-10, Vol.30 (10), p.2697-2702</ispartof><rights>Copyright American Chemical Society Oct 16, 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a385t-e3fcf2e876a5ed5e0c3c43af20081daa30bf14821f5dba8d5390e6bf48de5b6b3</citedby><cites>FETCH-LOGICAL-a385t-e3fcf2e876a5ed5e0c3c43af20081daa30bf14821f5dba8d5390e6bf48de5b6b3</cites><orcidid>0000-0002-3051-0728 ; 0000-0002-1299-7202 ; 0000-0002-3886-9516</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.9b00618$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00618$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,778,782,2754,27063,27911,27912,56725,56775</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31532192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Zi-Xian</creatorcontrib><creatorcontrib>Fa, Yu-Chen</creatorcontrib><creatorcontrib>Kempson, Ivan M</creatorcontrib><creatorcontrib>Tseng, S.-Ja</creatorcontrib><title>Repolarization of M2 to M1 Macrophages Triggered by Lactate Oxidase Released from Methylcellulose Hydrogel</title><title>Bioconjugate chemistry</title><addtitle>Bioconjugate Chem</addtitle><description>Deregulated proliferation of tumors is generally associated with altered energy metabolism. A high rate of anaerobic glycolysis in solid tumors contributes to an acidification of pH to ∼6.7–7.2 in the tumor microenvironment and lactate accumulation. Macrophages in the tumor microenvironment can be educated by tumor cells. Tumor-derived lactate induces the polarization of M2 macrophages and promotes tumor invasion and metastasis. However, a particular challenge is to sustain lactate depletion. We propose that the repolarization of the tumor-supportive M2 macrophage to the tumor-suppressive M1 macrophage after the depletion of lactate by lactate oxidase (LOX) released from the hydrogels in the tumor microenvironment may enhance the antitumor treatment efficacy.</description><subject>Acidification</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Depletion</subject><subject>Deregulation</subject><subject>Energy metabolism</subject><subject>Glycolysis</subject><subject>Hydrogels</subject><subject>Lactate oxidase</subject><subject>Lactic acid</subject><subject>Liquid oxygen</subject><subject>Macrophages</subject><subject>Metastases</subject><subject>Methylcellulose</subject><subject>Oxidase</subject><subject>Solid tumors</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>1043-1802</issn><issn>1520-4812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rGzEQhkVJaT7av9AKcull3ZG0WmuPIbRJwCYQ0rPQx8hes2s50i7U_fWVsRtCLz3NwDzzzsu8hHxhMGPA2Tfj8sx20cXtxq1xmLUWoGHqHblgkkNVK8bPSg-1qJgCfk4uc94AQMsU_0DOBZOCs5ZfkM0T7mJvUvfbjF3c0hjoktMx0iWjS-NS3K3NCjN9Tt1qhQk9tXu6MG40I9LHX503GekT9liqpyHFgS5xXO97h30_9bFM7_c-xRX2H8n7YPqMn071ivz88f359r5aPN493N4sKiOUHCsUwQWOat4YiV4iOOFqYQIHUMwbI8AGVivOgvTWKC9FC9jYUCuP0jZWXJGvR91dii8T5lEPXT7YMVuMU9act7xtgYEq6PU_6CZOaVvcaS6gmbeybg7U_EiVd-ScMOhd6gaT9pqBPsShSxz6TRz6FEfZ_HzSn-yA_nXv7_8LII7AQeH19v9k_wCiyZ0-</recordid><startdate>20191016</startdate><enddate>20191016</enddate><creator>Liao, Zi-Xian</creator><creator>Fa, Yu-Chen</creator><creator>Kempson, Ivan M</creator><creator>Tseng, S.-Ja</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3051-0728</orcidid><orcidid>https://orcid.org/0000-0002-1299-7202</orcidid><orcidid>https://orcid.org/0000-0002-3886-9516</orcidid></search><sort><creationdate>20191016</creationdate><title>Repolarization of M2 to M1 Macrophages Triggered by Lactate Oxidase Released from Methylcellulose Hydrogel</title><author>Liao, Zi-Xian ; Fa, Yu-Chen ; Kempson, Ivan M ; Tseng, S.-Ja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a385t-e3fcf2e876a5ed5e0c3c43af20081daa30bf14821f5dba8d5390e6bf48de5b6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acidification</topic><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Depletion</topic><topic>Deregulation</topic><topic>Energy metabolism</topic><topic>Glycolysis</topic><topic>Hydrogels</topic><topic>Lactate oxidase</topic><topic>Lactic acid</topic><topic>Liquid oxygen</topic><topic>Macrophages</topic><topic>Metastases</topic><topic>Methylcellulose</topic><topic>Oxidase</topic><topic>Solid tumors</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Zi-Xian</creatorcontrib><creatorcontrib>Fa, Yu-Chen</creatorcontrib><creatorcontrib>Kempson, Ivan M</creatorcontrib><creatorcontrib>Tseng, S.-Ja</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioconjugate chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Zi-Xian</au><au>Fa, Yu-Chen</au><au>Kempson, Ivan M</au><au>Tseng, S.-Ja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repolarization of M2 to M1 Macrophages Triggered by Lactate Oxidase Released from Methylcellulose Hydrogel</atitle><jtitle>Bioconjugate chemistry</jtitle><addtitle>Bioconjugate Chem</addtitle><date>2019-10-16</date><risdate>2019</risdate><volume>30</volume><issue>10</issue><spage>2697</spage><epage>2702</epage><pages>2697-2702</pages><issn>1043-1802</issn><eissn>1520-4812</eissn><abstract>Deregulated proliferation of tumors is generally associated with altered energy metabolism. A high rate of anaerobic glycolysis in solid tumors contributes to an acidification of pH to ∼6.7–7.2 in the tumor microenvironment and lactate accumulation. Macrophages in the tumor microenvironment can be educated by tumor cells. Tumor-derived lactate induces the polarization of M2 macrophages and promotes tumor invasion and metastasis. However, a particular challenge is to sustain lactate depletion. We propose that the repolarization of the tumor-supportive M2 macrophage to the tumor-suppressive M1 macrophage after the depletion of lactate by lactate oxidase (LOX) released from the hydrogels in the tumor microenvironment may enhance the antitumor treatment efficacy.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>31532192</pmid><doi>10.1021/acs.bioconjchem.9b00618</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3051-0728</orcidid><orcidid>https://orcid.org/0000-0002-1299-7202</orcidid><orcidid>https://orcid.org/0000-0002-3886-9516</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-1802 |
| ispartof | Bioconjugate chemistry, 2019-10, Vol.30 (10), p.2697-2702 |
| issn | 1043-1802 1520-4812 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2292990108 |
| source | ACS Publications |
| subjects | Acidification Anticancer properties Antitumor activity Depletion Deregulation Energy metabolism Glycolysis Hydrogels Lactate oxidase Lactic acid Liquid oxygen Macrophages Metastases Methylcellulose Oxidase Solid tumors Tumor cells Tumors |
| title | Repolarization of M2 to M1 Macrophages Triggered by Lactate Oxidase Released from Methylcellulose Hydrogel |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T12%3A54%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Repolarization%20of%20M2%20to%20M1%20Macrophages%20Triggered%20by%20Lactate%20Oxidase%20Released%20from%20Methylcellulose%20Hydrogel&rft.jtitle=Bioconjugate%20chemistry&rft.au=Liao,%20Zi-Xian&rft.date=2019-10-16&rft.volume=30&rft.issue=10&rft.spage=2697&rft.epage=2702&rft.pages=2697-2702&rft.issn=1043-1802&rft.eissn=1520-4812&rft_id=info:doi/10.1021/acs.bioconjchem.9b00618&rft_dat=%3Cproquest_cross%3E2306795468%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2306795468&rft_id=info:pmid/31532192&rfr_iscdi=true |