Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation

Background: P2X7 receptors (P2X7R) are ligand-gated ion channels activated by adenosine 5’-triphosphate (ATP), which are involved in processes that are dysfunctional in stress response and depression, such as neurotransmitter release, and neuroimmune response. Genetic and pharmacological inhibition...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2019-11, Vol.33 (11), p.1436-1446
Hauptverfasser:	Ribeiro, Deidiane E, Müller, Heidi K, Elfving, Betina, Eskelund, Amanda, Joca, Samia RL, Wegener, Gregers
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine triphosphate AKT protein Animal models Animals Antidepressants Brain-derived neurotrophic factor Cortex (frontal) Hippocampus Immune response Ion channels Ion channels (ligand-gated) Mental depression Neurotransmitter release p70 S6 kinase Receptor mechanisms Selective breeding Stress response TrkB receptors Tropomyosin
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