Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei

African trypanosomiasis, sleeping sickness in humans or nagana in animals, is a potentially fatal neglected tropical disease and a threat to 65 million human lives and 100 million small and large livestock animals in sub‐Saharan Africa. Available treatments for this devastating disease are few and h...

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Veröffentlicht in:	The FASEB journal 2019-11, Vol.33 (11), p.13002-13013
Hauptverfasser:	Balogun, Emmanuel Oluwadare, Inaoka, Daniel Ken, Shiba, Tomoo, Tsuge, Chiaki, May, Benjamin, Sato, Tomohiro, Kido, Yasutoshi, Nara, Takeshi, Aoki, Takashi, Honma, Teruki, Tanaka, Akiko, Inoue, Masayuki, Matsuoka, Shigeru, Michels, Paul A. M., Watanabe, Yoh‐Ichi, Moore, Anthony L., Harada, Shigeharu, Kita, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	African trypanosomiasis energy metabolism inhibitor rational drug design screening
Online-Zugang:	Volltext
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