Cucurbitacin E ameliorates lipopolysaccharide-evoked injury, inflammation and MUC5AC expression in bronchial epithelial cells by restraining the HMGB1-TLR4-NF-κB signaling

•CuE protects against BEAS-2B cell injury induced by LPS-mimicked asthmatic condition.•CuE has therapeutic potential on LPS-induced airway inflammation.•Treatment with CuE restrains LPS-evoked MUC5AC hypersecretion in BEAS-2B cells.•CuE affects asthma-induced airway epithelial cell dysfunction by th...

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Veröffentlicht in:	Molecular immunology 2019-10, Vol.114, p.571-577
Hauptverfasser:	Shang, Jin, Liu, Weihua, Yin, Chunyan, Chu, Haiping, Zhang, Meizhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Asthma Asthma - drug therapy Asthma - metabolism Bronchi - drug effects Bronchi - metabolism Cell Line Cells, Cultured CuE Epithelial Cells - drug effects Epithelial Cells - metabolism HMGB1 Protein - metabolism HMGB1-TLR4-NF-κB pathway Human bronchial epithelial cells Humans Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Insult and inflammation Interleukin-1beta - metabolism Lipopolysaccharides MUC5AC Mucin 5AC - metabolism NF-kappa B - metabolism Signal Transduction - drug effects Toll-Like Receptor 4 - metabolism Transcription Factor RelA - metabolism Triterpenes - metabolism Triterpenes - pharmacology Tumor Necrosis Factor-alpha - metabolism
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