Suppression of HSP70 inhibits the development of acute lymphoblastic leukemia via TAK1/Egr-1

•HSP70 is induced in leukomonocytes from the blood of ALL patients.•HSP70 suppression enhances apoptosis and inhibits cell proliferation.•HSP70 inhibition suppresses TAK1 and induces Egr-1.•HSP70 inhibition regulates Egr-1 via TAK1.•Hsp70 suppression induces cell apoptosis and decreases proliferatio...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-11, Vol.119, p.109399-109399, Article 109399
Hauptverfasser:	Guo, Dongfang, Zhang, Airong, Huang, Jing, Suo, Meifang, Zhong, Yaping, Liang, Yile
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adolescent Adult Apoptosis Cell Line, Tumor Cell Proliferation Child Child, Preschool Early Growth Response Protein 1 - metabolism Egr-1 Gene Expression Regulation, Leukemic HSP70 HSP70 Heat-Shock Proteins - metabolism Humans Infant Infant, Newborn MAP Kinase Kinase Kinases - metabolism Monocytes - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Proliferation TAK1 Young Adult
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