Mechanisms of Interplay between Transcription Factors and the 3D Genome

Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby serve as the protein anchors and determinants of 3D genome organization. Conversely, chromatin conformation shapes TF activity, for example, by looping TF-bound enhancers to distally located target genes. Despite consider...

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Veröffentlicht in:	Molecular cell 2019-10, Vol.76 (2), p.306-319
Hauptverfasser:	Kim, Seungsoo, Shendure, Jay
Format:	Artikel
Sprache:	eng
Schlagworte:	3D genome 4D genome Animals Binding Sites Chromatin - chemistry Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly chromosome conformation genome architecture genome conformation Humans intrinsically disordered regions Nucleic Acid Conformation phase separation Protein Binding Protein Conformation Structure-Activity Relationship transcription factor Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic transcriptional regulation
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