Associations of chairside salivary aMMP-8 findings with periodontal parameters, potentially periodontal pathogenic bacteria and selected blood parameters in systemically healthy adults
The aim of this cross-sectional study was to investigate associations between salivary active matrix-metalloproteinase 8 (aMMP-8) and periodontitis severity, potentially periodontal pathogenic bacteria as well as blood parameters in generally healthy participants. Therefore, 188 participants with a...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2019-10, Vol.95 (2), p.179-184 |
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| creator | Schmalz, Gerhard Hübscher, Anna Elisabeth Angermann, Helena Schmidt, Jana Schmickler, Jan Legler, Tobias J Ziebolz, Dirk |
| description | The aim of this cross-sectional study was to investigate associations between salivary active matrix-metalloproteinase 8 (aMMP-8) and periodontitis severity, potentially periodontal pathogenic bacteria as well as blood parameters in generally healthy participants.
Therefore, 188 participants with a mean age of 48.9 ± 8 years were examined. The periodontitis severity was assessed based on periodontal probing depth and clinical attachment loss. Both, aMMP-8 and microbiological analysis were performed using a validated, commercially available test system. Blood values were utilized from regular differential blood count.
The aMMP-8 findings were associated with the periodontitis severity (P |
| doi_str_mv | 10.1016/j.diagmicrobio.2019.05.006 |
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Therefore, 188 participants with a mean age of 48.9 ± 8 years were examined. The periodontitis severity was assessed based on periodontal probing depth and clinical attachment loss. Both, aMMP-8 and microbiological analysis were performed using a validated, commercially available test system. Blood values were utilized from regular differential blood count.
The aMMP-8 findings were associated with the periodontitis severity (P < 0.01), as well as with the prevalence of Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Parvimonas micra, Camphylobacter rectus and Eubacterium nodatum (Pi < 0.05). No associations between aMMP-8 and the examined blood parameters were found (Pi > 0.05).
In conclusion, salivary aMMP-8 findings seem to reflect periodontal disease severity as a result of an immunoreaction, especially against bacteria with high periodontal pathogenic potential.
•Salivary aMMP-8 can reflect periodontal disease severity in healthy adults.•Salivary aMMP-8 is associated to bacteria with high periodontal pathogenic potential.•Salivary aMMP-8 is not associated to parameters from differential blood count.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/j.diagmicrobio.2019.05.006</identifier><identifier>PMID: 31174997</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Bacteria - isolation & purification ; Bacterial Physiological Phenomena ; Biomarkers - analysis ; Biomarkers - blood ; Cross-Sectional Studies ; Female ; Humans ; Male ; Matrix Metalloproteinase 8 - analysis ; Middle Aged ; Periodontal Attachment Loss - enzymology ; Periodontal Attachment Loss - microbiology ; Periodontal Attachment Loss - pathology ; Periodontal Index ; Periodontitis - blood ; Periodontitis - diagnosis ; Periodontitis - enzymology ; Periodontitis - microbiology ; Saliva - enzymology</subject><ispartof>Diagnostic microbiology and infectious disease, 2019-10, Vol.95 (2), p.179-184</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-928796da16a627aaf286097be1506e037523ef99a4b5925f2944f89e9beef4bb3</citedby><cites>FETCH-LOGICAL-c380t-928796da16a627aaf286097be1506e037523ef99a4b5925f2944f89e9beef4bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S073288931930152X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31174997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmalz, Gerhard</creatorcontrib><creatorcontrib>Hübscher, Anna Elisabeth</creatorcontrib><creatorcontrib>Angermann, Helena</creatorcontrib><creatorcontrib>Schmidt, Jana</creatorcontrib><creatorcontrib>Schmickler, Jan</creatorcontrib><creatorcontrib>Legler, Tobias J</creatorcontrib><creatorcontrib>Ziebolz, Dirk</creatorcontrib><title>Associations of chairside salivary aMMP-8 findings with periodontal parameters, potentially periodontal pathogenic bacteria and selected blood parameters in systemically healthy adults</title><title>Diagnostic microbiology and infectious disease</title><addtitle>Diagn Microbiol Infect Dis</addtitle><description>The aim of this cross-sectional study was to investigate associations between salivary active matrix-metalloproteinase 8 (aMMP-8) and periodontitis severity, potentially periodontal pathogenic bacteria as well as blood parameters in generally healthy participants.
Therefore, 188 participants with a mean age of 48.9 ± 8 years were examined. The periodontitis severity was assessed based on periodontal probing depth and clinical attachment loss. Both, aMMP-8 and microbiological analysis were performed using a validated, commercially available test system. Blood values were utilized from regular differential blood count.
The aMMP-8 findings were associated with the periodontitis severity (P < 0.01), as well as with the prevalence of Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Parvimonas micra, Camphylobacter rectus and Eubacterium nodatum (Pi < 0.05). No associations between aMMP-8 and the examined blood parameters were found (Pi > 0.05).
In conclusion, salivary aMMP-8 findings seem to reflect periodontal disease severity as a result of an immunoreaction, especially against bacteria with high periodontal pathogenic potential.
•Salivary aMMP-8 can reflect periodontal disease severity in healthy adults.•Salivary aMMP-8 is associated to bacteria with high periodontal pathogenic potential.•Salivary aMMP-8 is not associated to parameters from differential blood count.</description><subject>Adult</subject><subject>Bacteria - isolation & purification</subject><subject>Bacterial Physiological Phenomena</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 8 - analysis</subject><subject>Middle Aged</subject><subject>Periodontal Attachment Loss - enzymology</subject><subject>Periodontal Attachment Loss - microbiology</subject><subject>Periodontal Attachment Loss - pathology</subject><subject>Periodontal Index</subject><subject>Periodontitis - blood</subject><subject>Periodontitis - diagnosis</subject><subject>Periodontitis - enzymology</subject><subject>Periodontitis - microbiology</subject><subject>Saliva - enzymology</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhLyCLEwcSbOfT3KryKbWCA5ytSTzZzMobB9tbtP-Mn4fLFlRx4mSN9MyM530YeyFFKYVsX-9KS7Dd0xj8QL5UQupSNKUQ7QO2kX2nCyE68ZBtRFepou91dcaexLgTQipdi8fsrJKyq7XuNuznRYx-JEjkl8j9xMcZKESyyCM4uoFw5HB9_aXo-USLpWUb-Q9KM18xkLd-SeD4CgH2mDDEV3z1CZdE4NzxHybNfosLjXyAMbMEHBbLIzrMpeWD897eG8Vp4fEYE-ZDf0-bEVya83fswaX4lD2awEV8dvees2_v3329_Fhcff7w6fLiqhirXqRCq5xHa0G20KoOYFJ9K3Q3oGxEi6LqGlXhpDXUQ6NVM-WA6qnXqAfEqR6G6py9PM1dg_9-wJjMnuKIzsGC_hCNUlrotmnqLqNvTmgWE2PAyayB9jlBI4W5NWd25r45c2vOiMZkc7n5-d2ew7BH-7f1j6oMvD0BmK-9IQwmjoTLiJZCTtBYT_-z5xeb-rbe</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Schmalz, Gerhard</creator><creator>Hübscher, Anna Elisabeth</creator><creator>Angermann, Helena</creator><creator>Schmidt, Jana</creator><creator>Schmickler, Jan</creator><creator>Legler, Tobias J</creator><creator>Ziebolz, Dirk</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201910</creationdate><title>Associations of chairside salivary aMMP-8 findings with periodontal parameters, potentially periodontal pathogenic bacteria and selected blood parameters in systemically healthy adults</title><author>Schmalz, Gerhard ; Hübscher, Anna Elisabeth ; Angermann, Helena ; Schmidt, Jana ; Schmickler, Jan ; Legler, Tobias J ; Ziebolz, Dirk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-928796da16a627aaf286097be1506e037523ef99a4b5925f2944f89e9beef4bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Bacteria - isolation & purification</topic><topic>Bacterial Physiological Phenomena</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase 8 - analysis</topic><topic>Middle Aged</topic><topic>Periodontal Attachment Loss - enzymology</topic><topic>Periodontal Attachment Loss - microbiology</topic><topic>Periodontal Attachment Loss - pathology</topic><topic>Periodontal Index</topic><topic>Periodontitis - blood</topic><topic>Periodontitis - diagnosis</topic><topic>Periodontitis - enzymology</topic><topic>Periodontitis - microbiology</topic><topic>Saliva - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmalz, Gerhard</creatorcontrib><creatorcontrib>Hübscher, Anna Elisabeth</creatorcontrib><creatorcontrib>Angermann, Helena</creatorcontrib><creatorcontrib>Schmidt, Jana</creatorcontrib><creatorcontrib>Schmickler, Jan</creatorcontrib><creatorcontrib>Legler, Tobias J</creatorcontrib><creatorcontrib>Ziebolz, Dirk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmalz, Gerhard</au><au>Hübscher, Anna Elisabeth</au><au>Angermann, Helena</au><au>Schmidt, Jana</au><au>Schmickler, Jan</au><au>Legler, Tobias J</au><au>Ziebolz, Dirk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of chairside salivary aMMP-8 findings with periodontal parameters, potentially periodontal pathogenic bacteria and selected blood parameters in systemically healthy adults</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>2019-10</date><risdate>2019</risdate><volume>95</volume><issue>2</issue><spage>179</spage><epage>184</epage><pages>179-184</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><abstract>The aim of this cross-sectional study was to investigate associations between salivary active matrix-metalloproteinase 8 (aMMP-8) and periodontitis severity, potentially periodontal pathogenic bacteria as well as blood parameters in generally healthy participants.
Therefore, 188 participants with a mean age of 48.9 ± 8 years were examined. The periodontitis severity was assessed based on periodontal probing depth and clinical attachment loss. Both, aMMP-8 and microbiological analysis were performed using a validated, commercially available test system. Blood values were utilized from regular differential blood count.
The aMMP-8 findings were associated with the periodontitis severity (P < 0.01), as well as with the prevalence of Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Parvimonas micra, Camphylobacter rectus and Eubacterium nodatum (Pi < 0.05). No associations between aMMP-8 and the examined blood parameters were found (Pi > 0.05).
In conclusion, salivary aMMP-8 findings seem to reflect periodontal disease severity as a result of an immunoreaction, especially against bacteria with high periodontal pathogenic potential.
•Salivary aMMP-8 can reflect periodontal disease severity in healthy adults.•Salivary aMMP-8 is associated to bacteria with high periodontal pathogenic potential.•Salivary aMMP-8 is not associated to parameters from differential blood count.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31174997</pmid><doi>10.1016/j.diagmicrobio.2019.05.006</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Bacteria - isolation & purification Bacterial Physiological Phenomena Biomarkers - analysis Biomarkers - blood Cross-Sectional Studies Female Humans Male Matrix Metalloproteinase 8 - analysis Middle Aged Periodontal Attachment Loss - enzymology Periodontal Attachment Loss - microbiology Periodontal Attachment Loss - pathology Periodontal Index Periodontitis - blood Periodontitis - diagnosis Periodontitis - enzymology Periodontitis - microbiology Saliva - enzymology |
| title | Associations of chairside salivary aMMP-8 findings with periodontal parameters, potentially periodontal pathogenic bacteria and selected blood parameters in systemically healthy adults |
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