CRISPR technologies for stem cell engineering and regenerative medicine

CRISPR/Cas9 system exploits the concerted action of Cas9 nuclease and programmable single guide RNA (sgRNA), and has been widely used for genome editing. The Cas9 nuclease activity can be abolished by mutation to yield the catalytically deactivated Cas9 (dCas9). Coupling with the customizable sgRNA...

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Veröffentlicht in:	Biotechnology advances 2019-12, Vol.37 (8), p.107447-107447, Article 107447
Hauptverfasser:	Hsu, Mu-Nung, Chang, Yu-Han, Truong, Vu Anh, Lai, Po-Liang, Nguyen, Thị Kieu Nuong, Hu, Yu-Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Cartilage Clustered Regularly Interspaced Short Palindromic Repeats CRISPR CRISPR-Cas Systems CRISPRa CRISPRi Deactivation Degeneration Gene Editing Gene expression Genome editing Mutation Nuclease Regeneration (physiology) Regenerative Medicine Skin Stem cell Stem Cells Tissue engineering
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