KIR Polymorphism Modulates the Size of the Adaptive NK Cell Pool in Human Cytomegalovirus-Infected Individuals

Acute infection with human CMV (HCMV) induces the development of adaptive NKG2C NK cells. In some cases, large expansions of this subset, characterized by coexpression of HLA-C-specific KIR, are stably maintained during the life-long latent phase of infection. The factors that control these unusual...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-10, Vol.203 (8), p.2301-2309
Hauptverfasser:	Manser, Angela R, Scherenschlich, Nadine, Thöns, Christine, Hengel, Hartmut, Timm, Jörg, Uhrberg, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytomegalovirus - genetics Cytomegalovirus - immunology Cytomegalovirus Infections - genetics Cytomegalovirus Infections - immunology Healthy Volunteers Humans Killer Cells, Natural - immunology Polymorphism, Genetic - genetics Receptors, KIR2DL1 - genetics Receptors, KIR2DL1 - immunology Receptors, KIR2DL2 - genetics Receptors, KIR2DL2 - immunology
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