The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma
Background To investigate the biological relationship, mechanism between perilipin2 and the occurrence, advancement of gastric carcinoma, and explore the mechanism of lipid metabolism disorder leading to gastric neoplasm, and propose that perilipin2 is presumably considered as a potential molecular...
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| Veröffentlicht in: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2020-03, Vol.23 (2), p.241-259 |
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| container_title | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association |
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| creator | Sun, Xiaoying Yang, Shaojuan Feng, Xuechao Zheng, Yaowu Zhou, Jinsong Wang, Hai Zhang, Yucheng Sun, Hongyan He, Chengyan |
| description | Background
To investigate the biological relationship, mechanism between perilipin2 and the occurrence, advancement of gastric carcinoma, and explore the mechanism of lipid metabolism disorder leading to gastric neoplasm, and propose that perilipin2 is presumably considered as a potential molecular biomarker of gastric carcinoma.
Methods
RNA-seq was applied to analyze perilipin2 and differentially expressed genes modulated by perilipin2 in neoplastic tissues of both perilipin2 overexpression and knockdown groups in vivo. The mechanism was discovered and confirmed by Rt-qPCR, immunoblotting, immunohistochemistry, staining and microassay, respectively. Cellular function experiments were performed by flow cytometry, CCK8, clonogenic assay, etc.
Results
Overexpression and knockdown of perilipin2 augmented the proliferation and apoptosis of gastric carcinoma cell lines SGC7901 and MGC803, respectively. The neoplastic cells with perilipin2-overexpression obtained more conspicuously rapid growth than knockdown group in vivo, and perilipin2 affected the proliferation and apoptosis of gastric carcinoma cells by modulating the related genes:acyl-coa synthetase long-chain family member 3, arachidonate 15-lipoxygenase, microtubule associated protein 1 light chain 3 alpha, pr/set domain 11 and importin 7 that were participated in Ferroptosis pathway. Moreover, RNA-seq indicated perilipin2 was an indispensable gene and protein in the suppression of Ferroptosis caused by abnormal lipometabolism in gastric carcinoma.
Conclusion
Our study expounded the facilitation of perilipin2 in regulating the proliferation and apoptosis of gastric carcinoma cells by modification in Ferroptosis pathway, and we interpreted that the mechanism of gastric neoplasm caused by obesity, we also discovered that pr/set domain 11 and importin 7 are novel transcription factors relevant to gastric carcinoma. Furthermore, perilipin2 probably serves not only as a diagnostic biomarker, but also a new therapeutic target. |
| doi_str_mv | 10.1007/s10120-019-01004-z |
| format | Article |
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To investigate the biological relationship, mechanism between perilipin2 and the occurrence, advancement of gastric carcinoma, and explore the mechanism of lipid metabolism disorder leading to gastric neoplasm, and propose that perilipin2 is presumably considered as a potential molecular biomarker of gastric carcinoma.
Methods
RNA-seq was applied to analyze perilipin2 and differentially expressed genes modulated by perilipin2 in neoplastic tissues of both perilipin2 overexpression and knockdown groups in vivo. The mechanism was discovered and confirmed by Rt-qPCR, immunoblotting, immunohistochemistry, staining and microassay, respectively. Cellular function experiments were performed by flow cytometry, CCK8, clonogenic assay, etc.
Results
Overexpression and knockdown of perilipin2 augmented the proliferation and apoptosis of gastric carcinoma cell lines SGC7901 and MGC803, respectively. The neoplastic cells with perilipin2-overexpression obtained more conspicuously rapid growth than knockdown group in vivo, and perilipin2 affected the proliferation and apoptosis of gastric carcinoma cells by modulating the related genes:acyl-coa synthetase long-chain family member 3, arachidonate 15-lipoxygenase, microtubule associated protein 1 light chain 3 alpha, pr/set domain 11 and importin 7 that were participated in Ferroptosis pathway. Moreover, RNA-seq indicated perilipin2 was an indispensable gene and protein in the suppression of Ferroptosis caused by abnormal lipometabolism in gastric carcinoma.
Conclusion
Our study expounded the facilitation of perilipin2 in regulating the proliferation and apoptosis of gastric carcinoma cells by modification in Ferroptosis pathway, and we interpreted that the mechanism of gastric neoplasm caused by obesity, we also discovered that pr/set domain 11 and importin 7 are novel transcription factors relevant to gastric carcinoma. Furthermore, perilipin2 probably serves not only as a diagnostic biomarker, but also a new therapeutic target.</description><identifier>ISSN: 1436-3291</identifier><identifier>EISSN: 1436-3305</identifier><identifier>DOI: 10.1007/s10120-019-01004-z</identifier><identifier>PMID: 31520166</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Abdominal Surgery ; Animals ; Apoptosis ; Arachidonate 15-lipoxygenase ; Biomarkers ; Biomarkers, Tumor - genetics ; Cancer Research ; Cell Proliferation ; Female ; Ferroptosis ; Ferroptosis - genetics ; Flow cytometry ; Gastric cancer ; Gastroenterology ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Immunoblotting ; Immunohistochemistry ; Lipid metabolism ; Lipid Metabolism - genetics ; Lipoxygenase ; Medicine ; Medicine & Public Health ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasia ; Oncology ; Original Article ; Perilipin-2 - antagonists & inhibitors ; Perilipin-2 - genetics ; Perilipin-2 - metabolism ; Ribonucleic acid ; RNA ; RNA-Seq ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Surgical Oncology ; Therapeutic applications ; Transcription factors ; Tumor cell lines ; Tumor Cells, Cultured ; Tumors ; Xenograft Model Antitumor Assays</subject><ispartof>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2020-03, Vol.23 (2), p.241-259</ispartof><rights>The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2019</rights><rights>The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-2b39dba87f30b2cd78cf24c0736c9cf091f7668435bab71c76a597868c88438f3</citedby><cites>FETCH-LOGICAL-c536t-2b39dba87f30b2cd78cf24c0736c9cf091f7668435bab71c76a597868c88438f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10120-019-01004-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10120-019-01004-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31520166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Xiaoying</creatorcontrib><creatorcontrib>Yang, Shaojuan</creatorcontrib><creatorcontrib>Feng, Xuechao</creatorcontrib><creatorcontrib>Zheng, Yaowu</creatorcontrib><creatorcontrib>Zhou, Jinsong</creatorcontrib><creatorcontrib>Wang, Hai</creatorcontrib><creatorcontrib>Zhang, Yucheng</creatorcontrib><creatorcontrib>Sun, Hongyan</creatorcontrib><creatorcontrib>He, Chengyan</creatorcontrib><title>The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma</title><title>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</title><addtitle>Gastric Cancer</addtitle><addtitle>Gastric Cancer</addtitle><description>Background
To investigate the biological relationship, mechanism between perilipin2 and the occurrence, advancement of gastric carcinoma, and explore the mechanism of lipid metabolism disorder leading to gastric neoplasm, and propose that perilipin2 is presumably considered as a potential molecular biomarker of gastric carcinoma.
Methods
RNA-seq was applied to analyze perilipin2 and differentially expressed genes modulated by perilipin2 in neoplastic tissues of both perilipin2 overexpression and knockdown groups in vivo. The mechanism was discovered and confirmed by Rt-qPCR, immunoblotting, immunohistochemistry, staining and microassay, respectively. Cellular function experiments were performed by flow cytometry, CCK8, clonogenic assay, etc.
Results
Overexpression and knockdown of perilipin2 augmented the proliferation and apoptosis of gastric carcinoma cell lines SGC7901 and MGC803, respectively. The neoplastic cells with perilipin2-overexpression obtained more conspicuously rapid growth than knockdown group in vivo, and perilipin2 affected the proliferation and apoptosis of gastric carcinoma cells by modulating the related genes:acyl-coa synthetase long-chain family member 3, arachidonate 15-lipoxygenase, microtubule associated protein 1 light chain 3 alpha, pr/set domain 11 and importin 7 that were participated in Ferroptosis pathway. Moreover, RNA-seq indicated perilipin2 was an indispensable gene and protein in the suppression of Ferroptosis caused by abnormal lipometabolism in gastric carcinoma.
Conclusion
Our study expounded the facilitation of perilipin2 in regulating the proliferation and apoptosis of gastric carcinoma cells by modification in Ferroptosis pathway, and we interpreted that the mechanism of gastric neoplasm caused by obesity, we also discovered that pr/set domain 11 and importin 7 are novel transcription factors relevant to gastric carcinoma. Furthermore, perilipin2 probably serves not only as a diagnostic biomarker, but also a new therapeutic target.</description><subject>Abdominal Surgery</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Arachidonate 15-lipoxygenase</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cancer Research</subject><subject>Cell Proliferation</subject><subject>Female</subject><subject>Ferroptosis</subject><subject>Ferroptosis - genetics</subject><subject>Flow cytometry</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Knockdown Techniques</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Lipid metabolism</subject><subject>Lipid Metabolism - genetics</subject><subject>Lipoxygenase</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Neoplasia</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Perilipin-2 - antagonists & inhibitors</subject><subject>Perilipin-2 - genetics</subject><subject>Perilipin-2 - metabolism</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA-Seq</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Surgical Oncology</subject><subject>Therapeutic applications</subject><subject>Transcription factors</subject><subject>Tumor cell lines</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1436-3291</issn><issn>1436-3305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9uFSEUhydGY2v1BVwYEjduRg9wB5ilabQ1aeKmrgnDwL30znBGYPzTx_FJ5fa2mrhwQSCc73wc8mualxTeUgD5LlOgDFqgfV0Am_b2UXNKN1y0nEP3-OHMenrSPMv5BoB2PRVPmxNOOwZUiNPm1_XOkRnH4IM1JWAk6Il3KeFSMIdMTByJGSKm2UxkCgvOrpgBp5BnUnYJ1-2O4DeX3I8luZwPhkPLPqLdj_j9zrdgcbGEKlgSbiPmEiwZAs4m7V0ii0uhmkNkJESyNbmkWrcm2RAr87x54s2U3Yv7_az58vHD9flle_X54tP5-6vWdlyUlg28HwejpOcwMDtKZT3bWJBc2N566KmXQqgN7wYzSGqlMF0vlVBW1Uvl-Vnz5uitQ35dXS56Dtm6aTLR4Zo1Yz30QBVARV__g97gmmKdTjPeKUmpAFUpdqRswpyT83pJof75p6agDwnqY4K6JqjvEtS3tenVvXodZjf-aXmIrAL8CORailuX_r79H-1vkb2rIg</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Sun, Xiaoying</creator><creator>Yang, Shaojuan</creator><creator>Feng, Xuechao</creator><creator>Zheng, Yaowu</creator><creator>Zhou, Jinsong</creator><creator>Wang, Hai</creator><creator>Zhang, Yucheng</creator><creator>Sun, Hongyan</creator><creator>He, Chengyan</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20200301</creationdate><title>The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma</title><author>Sun, Xiaoying ; Yang, Shaojuan ; Feng, Xuechao ; Zheng, Yaowu ; Zhou, Jinsong ; Wang, Hai ; Zhang, Yucheng ; Sun, Hongyan ; He, Chengyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-2b39dba87f30b2cd78cf24c0736c9cf091f7668435bab71c76a597868c88438f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdominal Surgery</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Arachidonate 15-lipoxygenase</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cancer Research</topic><topic>Cell Proliferation</topic><topic>Female</topic><topic>Ferroptosis</topic><topic>Ferroptosis - genetics</topic><topic>Flow cytometry</topic><topic>Gastric cancer</topic><topic>Gastroenterology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Lipid metabolism</topic><topic>Lipid Metabolism - genetics</topic><topic>Lipoxygenase</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Neoplasia</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Perilipin-2 - antagonists & inhibitors</topic><topic>Perilipin-2 - genetics</topic><topic>Perilipin-2 - metabolism</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA-Seq</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Surgical Oncology</topic><topic>Therapeutic applications</topic><topic>Transcription factors</topic><topic>Tumor cell lines</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Xiaoying</creatorcontrib><creatorcontrib>Yang, Shaojuan</creatorcontrib><creatorcontrib>Feng, Xuechao</creatorcontrib><creatorcontrib>Zheng, Yaowu</creatorcontrib><creatorcontrib>Zhou, Jinsong</creatorcontrib><creatorcontrib>Wang, Hai</creatorcontrib><creatorcontrib>Zhang, Yucheng</creatorcontrib><creatorcontrib>Sun, Hongyan</creatorcontrib><creatorcontrib>He, Chengyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Xiaoying</au><au>Yang, Shaojuan</au><au>Feng, Xuechao</au><au>Zheng, Yaowu</au><au>Zhou, Jinsong</au><au>Wang, Hai</au><au>Zhang, Yucheng</au><au>Sun, Hongyan</au><au>He, Chengyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma</atitle><jtitle>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</jtitle><stitle>Gastric Cancer</stitle><addtitle>Gastric Cancer</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>23</volume><issue>2</issue><spage>241</spage><epage>259</epage><pages>241-259</pages><issn>1436-3291</issn><eissn>1436-3305</eissn><abstract>Background
To investigate the biological relationship, mechanism between perilipin2 and the occurrence, advancement of gastric carcinoma, and explore the mechanism of lipid metabolism disorder leading to gastric neoplasm, and propose that perilipin2 is presumably considered as a potential molecular biomarker of gastric carcinoma.
Methods
RNA-seq was applied to analyze perilipin2 and differentially expressed genes modulated by perilipin2 in neoplastic tissues of both perilipin2 overexpression and knockdown groups in vivo. The mechanism was discovered and confirmed by Rt-qPCR, immunoblotting, immunohistochemistry, staining and microassay, respectively. Cellular function experiments were performed by flow cytometry, CCK8, clonogenic assay, etc.
Results
Overexpression and knockdown of perilipin2 augmented the proliferation and apoptosis of gastric carcinoma cell lines SGC7901 and MGC803, respectively. The neoplastic cells with perilipin2-overexpression obtained more conspicuously rapid growth than knockdown group in vivo, and perilipin2 affected the proliferation and apoptosis of gastric carcinoma cells by modulating the related genes:acyl-coa synthetase long-chain family member 3, arachidonate 15-lipoxygenase, microtubule associated protein 1 light chain 3 alpha, pr/set domain 11 and importin 7 that were participated in Ferroptosis pathway. Moreover, RNA-seq indicated perilipin2 was an indispensable gene and protein in the suppression of Ferroptosis caused by abnormal lipometabolism in gastric carcinoma.
Conclusion
Our study expounded the facilitation of perilipin2 in regulating the proliferation and apoptosis of gastric carcinoma cells by modification in Ferroptosis pathway, and we interpreted that the mechanism of gastric neoplasm caused by obesity, we also discovered that pr/set domain 11 and importin 7 are novel transcription factors relevant to gastric carcinoma. Furthermore, perilipin2 probably serves not only as a diagnostic biomarker, but also a new therapeutic target.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>31520166</pmid><doi>10.1007/s10120-019-01004-z</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2020-03, Vol.23 (2), p.241-259 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Animals Apoptosis Arachidonate 15-lipoxygenase Biomarkers Biomarkers, Tumor - genetics Cancer Research Cell Proliferation Female Ferroptosis Ferroptosis - genetics Flow cytometry Gastric cancer Gastroenterology Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Immunoblotting Immunohistochemistry Lipid metabolism Lipid Metabolism - genetics Lipoxygenase Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Neoplasia Oncology Original Article Perilipin-2 - antagonists & inhibitors Perilipin-2 - genetics Perilipin-2 - metabolism Ribonucleic acid RNA RNA-Seq Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Surgical Oncology Therapeutic applications Transcription factors Tumor cell lines Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays |
| title | The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma |
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