miR-221-5p acts as an oncogene and predicts worse survival in patients of renal cell cancer

•MiR-221-5p is significantly up-regulated in RCC tissues and RCC cell lines.•MiR-221-5p promotes cell proliferation, mobility and inhibits cell apoptosis in 786-O and ACHN cell lines.•The Kaplan-Meier analysis indicated that patients with high expression of miR-221-5p had a significantly poor progno...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2019-11, Vol.119, p.109406-109406, Article 109406
Hauptverfasser:	Liu, Shangwen, Wang, Yadong, Li, Wengang, Yu, Shaolong, Wen, Zhipeng, Chen, Zhifeng, Lin, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis - genetics Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Female Gene Expression Regulation, Neoplastic Humans Kaplan-Meier Estimate Kidney Neoplasms - genetics Kidney Neoplasms - pathology Male MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-221-5p Oncogenes Prognosis Prognosis biomarkers Renal cell cancer Reproducibility of Results ROC Curve Survival Analysis Up-Regulation - genetics
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