Determination of five neurotransmitters in the rat brain for the study of the hypnotic effects of Ziziphi Spinosae Semen aqueous extract on insomnia rat model by UPLC-MS/MS

Ziziphi Spinosae Semen (ZSS) has been used for treatment of insomnia in China for centuries. To reveal the influence of insomnia on the levels of the neurotransmitters including serotonin (5-HT), glutamic acid (Glu), γ-aminobutyric acid (GABA), noradrenaline (NE) and dopamine (DA), and to study the...

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Veröffentlicht in:	Chinese journal of natural medicines 2019-07, Vol.17 (7), p.551-560
Hauptverfasser:	YAN, Yan, LI, Qiang, DU, Hui-Zhi, SHEN, Chen-Xi, LI, Ai-Ping, PEI, Xiang-Ping, DU, Chen-Hui, QIN, Xue-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Chromatography, High Pressure Liquid Disease Models, Animal Fenclonine - toxicity Hypnotic effects Hypnotics and Sedatives - chemistry Hypnotics and Sedatives - pharmacology Hypnotics and Sedatives - therapeutic use Male Medicine, Chinese Traditional Neurotransmitter Agents - metabolism Neurotransmitters Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats, Sprague-Dawley Sleep Initiation and Maintenance Disorders - chemically induced Sleep Initiation and Maintenance Disorders - drug therapy Sleep Initiation and Maintenance Disorders - metabolism Tandem Mass Spectrometry UPLC-MS/MS Ziziphi Spinosae Semen Ziziphus - chemistry
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