Chronic central miR-29b antagonism alleviates angiotensin II-induced hypertension and vascular endothelial dysfunction

Dysregulation of miR-29 has been revealed in multiple diseases, but its role in the development of hypertension and vascular endothelial dysfunction has not been defined. Here, we found that, compared with the wild-type (WT) Wistar rats, miR-29b was robustly upregulated in spontaneously hypertensive...

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Veröffentlicht in:	Life sciences (1973) 2019-10, Vol.235, p.116862-116862, Article 116862
Hauptverfasser:	Sun, Lili, Zhang, Junjian, Li, Yunwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines - blood Angiotensin Angiotensin II Angiotensin II - adverse effects Angiotensin II - blood Animals Aorta Blood pressure Blood Pressure - drug effects Cell migration Cell Movement - physiology Cell proliferation Cell Proliferation - physiology CTRP6 Down-Regulation - drug effects Endothelial cells Endothelial Cells - drug effects Endothelin 1 Endothelin-1 - blood Hypertension Hypertension - chemically induced Hypertension - genetics Hypertension - physiopathology Hypertension - prevention & control L-Lactate Dehydrogenase - metabolism Male MicroRNAs - agonists MicroRNAs - antagonists & inhibitors MicroRNAs - biosynthesis MicroRNAs - genetics miR-29b miRNA mRNA Nitric Oxide - blood Phosphorylation Phosphorylation - drug effects PPARγ/angiotensin II Proteins Rats Rats, Inbred SHR Reactive Oxygen Species - metabolism Secretion Signal Transduction - drug effects Systolic pressure Up-Regulation - drug effects Vascular endothelial dysfunction
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