Hepatic Gluconeogenic Response to Single and Long-Term SGLT2 Inhibition in Lean/Obese Male Hepatic G6pc-Reporter Mice

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) consistently reduces blood glucose levels in type 2 diabetes mellitus but increases hepatic gluconeogenic gene expression and glucose production, offsetting its glucose-lowering effect. This study aimed to elucidate the effect of SGLT2i on hepatic gl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2019-12, Vol.160 (12), p.2811-2824
Hauptverfasser:	Inaba, Yuka, Hashiuchi, Emi, Watanabe, Hitoshi, Kimura, Kumi, Sato, Makoto, Kobayashi, Masaki, Matsumoto, Michihiro, Kitamura, Tadahiro, Kasuga, Masato, Inoue, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Blood Blood glucose Carrier proteins Complications and side effects Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet Diet, High-Fat Endocrinology Gene expression Genetic aspects Gluconeogenesis Gluconeogenesis - drug effects Glucose Glucose-6-Phosphatase - genetics Health aspects Insulin Insulin - blood Insulin Resistance Liver Liver - drug effects Liver diseases Male Mice, Inbred C57BL Na+/glucose cotransporter Obesity Obesity - drug therapy Obesity - metabolism Phosphorylation Risk factors Sodium-Glucose Transporter 2 Inhibitors - administration & dosage
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!