De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

Macroautophagy/autophagy can enable cancer cells to withstand cellular stress and maintain bioenergetic homeostasis by sequestering cellular components into newly formed double-membrane vesicles destined for lysosomal degradation, potentially affecting the efficacy of anti-cancer treatments. Using 1...

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Veröffentlicht in:	Autophagy 2020-06, Vol.16 (6), p.1044-1060
Hauptverfasser:	Andrejeva, Gabriela, Gowan, Sharon, Lin, Gigin, Wong Te Fong, Anne-Christine LF, Shamsaei, Elham, Parkes, Harry G., Mui, James, Raynaud, Florence I., Asad, Yasmin, Vizcay-Barrena, Gema, Nikitorowicz-Buniak, Joanna, Valenti, Melanie, Howell, Louise, Fleck, Roland A., Martin, Lesley-Ann, Kirkin, Vladimir, Leach, Martin O., Chung, Yuen-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Autophagosome Autophagosomes - drug effects Autophagosomes - enzymology Autophagosomes - metabolism Autophagosomes - ultrastructure autophagy bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Cell Line, Tumor CHO Cells Choline - metabolism choline phospholipids Choline-Phosphate Cytidylyltransferase - genetics Choline-Phosphate Cytidylyltransferase - metabolism Cricetulus CTP:phosphocholine cytidylyltransferase Fibroblasts - drug effects Fibroblasts - metabolism Furans - pharmacology Gene Knockout Techniques Humans Intracellular Membranes - drug effects Intracellular Membranes - enzymology Intracellular Membranes - metabolism Macroautophagy - drug effects Magnetic Resonance Spectroscopy Mass Spectrometry Metabolomics Mice Microscopy, Electron, Transmission Microtubule-Associated Proteins - metabolism phosphatidylcholine Phosphatidylcholines - biosynthesis Phosphoinositide-3 Kinase Inhibitors propargylcholine Pyridines - pharmacology Pyrimidines - pharmacology Research Paper Vacuoles - drug effects Vacuoles - metabolism
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