Effects of grape products on blood lipids: a systematic review and dose-response meta-analysis of randomized controlled trials
The purpose of the present study was to critically assess the effects of grape product supplementation on lipid profiles in adults. A comprehensive electronic search was performed with no limitation in time and language. All randomized controlled trials (RCT) that reported the effects of grape produ...
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| Veröffentlicht in: | Food & function 2019-10, Vol.10 (10), p.6399-6416 |
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| creator | Ghaedi, Ehsan Moradi, Sajjad Aslani, Zahra Kord-Varkaneh, Hamed Miraghajani, Maryam Mohammadi, Hamed |
| description | The purpose of the present study was to critically assess the effects of grape product supplementation on lipid profiles in adults. A comprehensive electronic search was performed with no limitation in time and language. All randomized controlled trials (RCT) that reported the effects of grape products in any form on lipid profiles were included. Moreover, fifty-nine arms from forty-eight RCTs were included in the present study. Meta-analysis indicated that the consumption of grape products reduced the concentration of total cholesterol (MD: -6.196 mg dl-1, 95% CI: -9.203, -3.189), low-density lipoprotein (MD: -4.964 mg dl-1, 95% CI: -7.594, -2.334) and triglyceride (MD: -7.641 mg dl-1, 95% CI: -12.120, -3.162). However, grape products did not have significant effects on the concentration of high-density lipoprotein (MD: 0.385 mg dl-1, 95% CI: -0.364, 1.133). Grape product supplementation changed the HDL and LDL in a non-linear fashion based on the dose of polyphenols. The present study revealed that grape products might have a favorable role in the achievement of a lipid profile target. |
| doi_str_mv | 10.1039/c9fo01248f |
| format | Article |
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A comprehensive electronic search was performed with no limitation in time and language. All randomized controlled trials (RCT) that reported the effects of grape products in any form on lipid profiles were included. Moreover, fifty-nine arms from forty-eight RCTs were included in the present study. Meta-analysis indicated that the consumption of grape products reduced the concentration of total cholesterol (MD: -6.196 mg dl-1, 95% CI: -9.203, -3.189), low-density lipoprotein (MD: -4.964 mg dl-1, 95% CI: -7.594, -2.334) and triglyceride (MD: -7.641 mg dl-1, 95% CI: -12.120, -3.162). However, grape products did not have significant effects on the concentration of high-density lipoprotein (MD: 0.385 mg dl-1, 95% CI: -0.364, 1.133). Grape product supplementation changed the HDL and LDL in a non-linear fashion based on the dose of polyphenols. The present study revealed that grape products might have a favorable role in the achievement of a lipid profile target.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/c9fo01248f</identifier><identifier>PMID: 31517353</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Adult ; Aged ; Cholesterol ; Clinical trials ; Density ; Dietary Supplements - analysis ; Female ; Fruit - chemistry ; Fruit - metabolism ; Grapes ; High density lipoprotein ; Humans ; Lipids ; Lipids - blood ; Lipids - chemistry ; Low density lipoprotein ; Male ; Meta-analysis ; Middle Aged ; Plant Extracts - administration & dosage ; Plant Extracts - metabolism ; Polyphenols ; Randomization ; Randomized Controlled Trials as Topic ; Supplements ; Systematic review ; Triglycerides ; Vitis - chemistry ; Vitis - metabolism ; Young Adult</subject><ispartof>Food & function, 2019-10, Vol.10 (10), p.6399-6416</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-f9d5800e01eba9f2e80a45166564c39b2fe973e659f5b47032e45a782e2782723</citedby><cites>FETCH-LOGICAL-c381t-f9d5800e01eba9f2e80a45166564c39b2fe973e659f5b47032e45a782e2782723</cites><orcidid>0000-0003-4095-1591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31517353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghaedi, Ehsan</creatorcontrib><creatorcontrib>Moradi, Sajjad</creatorcontrib><creatorcontrib>Aslani, Zahra</creatorcontrib><creatorcontrib>Kord-Varkaneh, Hamed</creatorcontrib><creatorcontrib>Miraghajani, Maryam</creatorcontrib><creatorcontrib>Mohammadi, Hamed</creatorcontrib><title>Effects of grape products on blood lipids: a systematic review and dose-response meta-analysis of randomized controlled trials</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>The purpose of the present study was to critically assess the effects of grape product supplementation on lipid profiles in adults. 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The present study revealed that grape products might have a favorable role in the achievement of a lipid profile target.</description><subject>Adult</subject><subject>Aged</subject><subject>Cholesterol</subject><subject>Clinical trials</subject><subject>Density</subject><subject>Dietary Supplements - analysis</subject><subject>Female</subject><subject>Fruit - chemistry</subject><subject>Fruit - metabolism</subject><subject>Grapes</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipids - chemistry</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - metabolism</subject><subject>Polyphenols</subject><subject>Randomization</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Supplements</subject><subject>Systematic review</subject><subject>Triglycerides</subject><subject>Vitis - chemistry</subject><subject>Vitis - metabolism</subject><subject>Young Adult</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9LxDAQxYMouqx78QNIwIsI1fxp2sSbLK4KC3tR8FbSdiJZ2qYmrbIe_OzG1fXgHGYew48Hj4fQCSWXlHB1VSnjCGWpNHtowkjKkkyQ5_2dTlV2hGYhrEkcrpRU8hAdcSpozgWfoM9bY6AaAnYGv3jdA-69q8ftp8Nl41yNG9vbOlxjjcMmDNDqwVbYw5uFd6y7GtcuQOIh9K4LgFsYdKI73WyC3dr6yLjWfkCNK9cN3jVNlIO3ugnH6MDEA7PfO0VPi9vH-X2yXN09zG-WScUlHRKjaiEJAUKh1MowkESngmaZyNKKq5IZUDmHTCgjyjQnnEEqdC4ZsLhyxqfo_Mc3pnsdIQxFa0MFTaM7cGMoGFNEcilyHtGzf-jajT7miRQnQspcqG_q4oeqvAvBgyl6b1vtNwUlxXcxxVwtVttiFhE-_bUcyxbqP3RXA_8CSEOI5A</recordid><startdate>20191016</startdate><enddate>20191016</enddate><creator>Ghaedi, Ehsan</creator><creator>Moradi, Sajjad</creator><creator>Aslani, Zahra</creator><creator>Kord-Varkaneh, Hamed</creator><creator>Miraghajani, Maryam</creator><creator>Mohammadi, Hamed</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4095-1591</orcidid></search><sort><creationdate>20191016</creationdate><title>Effects of grape products on blood lipids: a systematic review and dose-response meta-analysis of randomized controlled trials</title><author>Ghaedi, Ehsan ; 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A comprehensive electronic search was performed with no limitation in time and language. All randomized controlled trials (RCT) that reported the effects of grape products in any form on lipid profiles were included. Moreover, fifty-nine arms from forty-eight RCTs were included in the present study. Meta-analysis indicated that the consumption of grape products reduced the concentration of total cholesterol (MD: -6.196 mg dl-1, 95% CI: -9.203, -3.189), low-density lipoprotein (MD: -4.964 mg dl-1, 95% CI: -7.594, -2.334) and triglyceride (MD: -7.641 mg dl-1, 95% CI: -12.120, -3.162). However, grape products did not have significant effects on the concentration of high-density lipoprotein (MD: 0.385 mg dl-1, 95% CI: -0.364, 1.133). Grape product supplementation changed the HDL and LDL in a non-linear fashion based on the dose of polyphenols. 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| subjects | Adult Aged Cholesterol Clinical trials Density Dietary Supplements - analysis Female Fruit - chemistry Fruit - metabolism Grapes High density lipoprotein Humans Lipids Lipids - blood Lipids - chemistry Low density lipoprotein Male Meta-analysis Middle Aged Plant Extracts - administration & dosage Plant Extracts - metabolism Polyphenols Randomization Randomized Controlled Trials as Topic Supplements Systematic review Triglycerides Vitis - chemistry Vitis - metabolism Young Adult |
| title | Effects of grape products on blood lipids: a systematic review and dose-response meta-analysis of randomized controlled trials |
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